在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GLIS2 Antibody, FITC conjugated

GLIS2 Antibody, FITC conjugated

  • 中文名稱：
    GLIS2兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA861185LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GLIS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GLIS2
  • 別名：
    FLJ38247 antibody; GLI similar 2 antibody; GLI-similar 2 antibody; GLIS 2 antibody; GLIS family zinc finger 2 antibody; glis2 antibody; GLIS2_HUMAN antibody; Kruppel like zinc finger protein GLIS2 antibody; Neuronal Krueppel-like protein antibody; Zinc finger protein GLIS2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein GLIS2 protein (332-505AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.
  • 基因功能參考文獻：
    1. CBFA2T3-GLIS2 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome. PMID: 28063190
    2. specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia. PMID: 28292442
    3. Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary. PMID: 27094503
    4. Nephronophthisis 7-related mutation C175R affects both localization and function of GLIS2 protein. PMID: 26374130
    5. Glis2/NPHP7 is extensively modified by post-translational modifications PMID: 26083374
    6. Findings are unprecedented and indicate that the DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML. PMID: 24127550
    7. BBS11 promotes accumulation of NPHP7, changing the properties of NPHP7. TRIM32 Modulates the Transcriptional Activities of Glis2 PMID: 24500717
    8. Recessive mutation in GLIS2 gene is associated with Caroli disease. PMID: 23559409
    9. Identification of a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 fusion protein. PMID: 23153540
    10. Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity PMID: 21127075
    11. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions PMID: 11741991
    12. Glis2 functions as a negative modulator of beta-catenin/TCF-mediated transcription. PMID: 17289029
    13. identification of Gli-similar 2 (Glis2) as a novel binding protein for p120 catenin PMID: 17344476
    14. Study identified Glis2 as a transcription factor mutated in Nephronophthisis and demonstrate its essential role for the maintenance of renal tissue architecture through prevention of apoptosis and fibrosis. PMID: 17618285

    顯示更多

    收起更多

  • 相關疾病：
    Nephronophthisis 7 (NPHP7)
  • 亞細胞定位：
    Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    GLI C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
  • 數據庫鏈接：

    HGNC: 29450

    OMIM: 608539

    KEGG: hsa:84662

    STRING: 9606.ENSP00000262366

    UniGene: Hs.592087



主站蜘蛛池模板： 乌克兰少妇性做爰| 网禁拗女稀缺资源在线观看| 又色又爽又黄18禁美女裸身无遮挡| 看全色黄大色大片免费久久| 午夜无码大尺度福利视频| 少妇人妻挤奶水中文视频毛片 | 午夜一区一品日本| 亚洲欧洲日产国码无码久久99| 成人午夜看黄在线尤物成人| 色伦专区97中文字幕| 性饥渴的农村熟妇| 国产乱人对白| 2021久久精品国产99国产精品| 99国产欧美久久久精品| 97久久国产成人免费网站| 97精品超碰一区二区三区| 超碰人人超碰人人| 青青草无码免费一二三区 | 狠狠色噜噜狠狠狠888米奇 | 国厂精品114福利电影免费| 99久久久无码国产精品免费砚床| 久久久亚洲欧洲日产国码是av| 蜜桃无码一区二区三区| 中文av岛国无码免费播放| 一区二三区在线 | 中国| 欧美乱人伦人妻中文字幕| 日韩av无码久久一区二区| 九九热久久只有精品2| 无码免费一区二区三区| 五月天激情电影| 免费两性的视频网站| 国产精品乱码高清在线观看| 国产精品午夜福利视频234区 | 久久综合丝袜日本网| 国产在线不卡人成视频| 漂亮人妻洗澡被公强 日日躁| 少妇挑战三个黑人惨叫4p国语| 粉嫩被粗大进进出出视频| 欧美成人aa大片| √天堂8资源中文在线| 无码人妻久久一区二区三区|