在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GIPR Antibody

  • 中文名稱:
    GIPR兔多克隆抗體
  • 貨號:
    CSB-PA214765
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue, Primary antibody: CSB-PA214765(GIPR Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GIPR; Gastric inhibitory polypeptide receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human GIPR
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能參考文獻:
    1. an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients. PMID: 28744963
    2. Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies. PMID: 27641811
    3. GIPR overexpression does not appear to affect acromegalic patients' clinical features PMID: 28179449
    4. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 and dynamin and its subsequent intracellular trafficking. GIP stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes. PMID: 26225752
    5. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. PMID: 26395740
    6. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. PMID: 25321336
    7. The potential future role of gastric inhibitory peptide (GIP) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade. PMID: 25591947
    8. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
    9. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors PMID: 24565507
    10. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels. PMID: 24512489
    11. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls. PMID: 24086540
    12. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk. PMID: 24446656
    13. Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy. PMID: 24238043
    14. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
    15. Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer. PMID: 22412906
    16. Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. PMID: 22399504
    17. Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive. PMID: 22112810
    18. The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet. PMID: 22237064
    19. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
    20. Variations of the GIPR sequence are not associated with childhood obesity. PMID: 20516203
    21. Variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)), were identified. PMID: 20081857
    22. Proximal 5' flanking region is TATA-less and contains a GC-rich region involved in cellular expression. PMID: 12530665
    23. differences in cellular response to gastric inhibitory polypeptide(GIP) mediated by endothelin-1 may be related to differences in activation of GIP receptor splice variants PMID: 12721154
    24. Glucose-stimulated insulin secretion is maintained despite complete absence of both GIP-1 and GIP receptors. Role for incretin receptors as essential downstream targets for glucoregulatory actions of DPP-IV inhibitors. PMID: 15111503
    25. Proximal promoter of GIP-R gene contains a GC-rich region capable of binding to Sp1 and SP3. PMID: 15666829
    26. the promoter region of the GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors PMID: 16087722
    27. GIPR adipose tissue gene expression was significantly lower in insulin resistant obese non-diabetic women PMID: 17395281
    28. GIPR overexpression was observed in pediatric and adult adrenocortical tumors PMID: 18971217
    29. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. PMID: 19211686
    30. Our data suggest a potential relevance of GIPR variants for obesity. PMID: 19254363
    31. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GLP-1R and GIP-R. PMID: 19386626

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 2 family
  • 數據庫鏈接:

    HGNC: 4271

    OMIM: 137241

    KEGG: hsa:2696

    STRING: 9606.ENSP00000467494

    UniGene: Hs.251412



主站蜘蛛池模板: 国产av无码专区亚洲草草| 人人人妻人人澡人人爽欧美一区| 亚洲精华国产精华精华液网站| 欧美性生交xxxxx久久久| 日韩乱码在线观看免费视频网站| 国内偷窥一区二区三区视频| 一本大道大臿蕉视频无码| 国产一区二区三区不卡av| 国产精品igao视频| 国产又黄又刺激又高潮的网站| 大香伊蕉日本一区二区| 国产亚洲精品a在线观看下载| 业余 自由 性别 成熟偷窥| 99精品国产再热久久无毒不卡| 免费无遮挡很爽很污很黄的网站 | 高清无码爆乳潮喷在线观看| 无卡无码无免费毛片| 国产毛多水多高潮高清| 亚洲欧美日韩视频高清专区| 精品亚洲国产成人av不卡| 四虎免费大片aⅴ入口| 毛片tv网站无套内射tv网站| 亚洲乱码av中文一区二区软件| 热re99久久精品国产99热| 欧美一区二区三区啪啪| 中文字幕日韩精品亚洲一区| 尤物蜜芽国产成人精品区| 妺妺窝人体色www看人体| 日本一二三区视频在线| 少妇人妻大乳在线视频不卡| 免费很黄无遮挡的视频| 国产乱xxxxx97国语对白| 久久tv中文字幕首页| 老男人久久青草av高清| 99久久精品费精品国产一区二区| 97精品人妻系列无码人妻| 一本久道久久综合狠狠躁av| 亚洲日韩国产精品无码av| 婷婷色婷婷开心五月四房播播| 国产好爽…又高潮了毛片| 午夜福利视频一区二区手机免费看 |