在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GIPR Recombinant Monoclonal Antibody

  • 中文名稱:
    GIPR重組抗體
  • 貨號:
    CSB-RA009438MA2HU
  • 規格:
    ¥1320
  • 圖片:
    • Western Blot
      Positive WB detected in:Hela whole cell lysate, PC-3 whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate
      All lanes: GIPR antibody at 1:1000
      Secondary
      Goat polyclonal to human IgG at 1/50000 dilution
      Predicted band size: 54 kDa,49 kDa,50 kDa
      Observed band size: 54 kDa
  • 其他:

產品詳情

  • 產品描述:
    CSB-RA009438MA2HU GIPR重組單克隆抗體是針對胃抑制多肽受體(GIPR)開發的高特異性科研工具,該靶點屬于G蛋白偶聯受體(GPCR)家族,在調節胰島素分泌、能量代謝及脂肪儲存中發揮重要作用,與2型糖尿病、肥胖等代謝性疾病密切相關。本抗體通過重組技術制備,具有高批次一致性,經嚴格驗證可應用于酶聯免疫吸附實驗(ELISA)和蛋白質免疫印跡(WB),其中WB實驗推薦使用1:500至1:5000的稀釋范圍,實驗結果可呈現清晰的特異性條帶。該產品適用于探索GIPR在代謝調控中的分子機制、評估受體表達水平變化及其與疾病關聯性研究,也可為開發靶向GIPR通路的新型干預策略提供實驗支持,廣泛應用于細胞生物學、分子病理學及藥理研究等領域,為科研人員提供可靠的數據支持。
  • Uniprot No.:
  • 基因名:
  • 別名:
    Gastric inhibitory polypeptide receptor, GIPR
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human GIPR protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Human IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    32C2
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能參考文獻:
    1. an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients. PMID: 28744963
    2. Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies. PMID: 27641811
    3. GIPR overexpression does not appear to affect acromegalic patients' clinical features PMID: 28179449
    4. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 and dynamin and its subsequent intracellular trafficking. GIP stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes. PMID: 26225752
    5. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. PMID: 26395740
    6. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. PMID: 25321336
    7. The potential future role of gastric inhibitory peptide (GIP) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade. PMID: 25591947
    8. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
    9. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors PMID: 24565507
    10. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels. PMID: 24512489
    11. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls. PMID: 24086540
    12. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk. PMID: 24446656
    13. Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy. PMID: 24238043
    14. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
    15. Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer. PMID: 22412906
    16. Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. PMID: 22399504
    17. Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive. PMID: 22112810
    18. The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet. PMID: 22237064
    19. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
    20. Variations of the GIPR sequence are not associated with childhood obesity. PMID: 20516203
    21. Variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)), were identified. PMID: 20081857
    22. Proximal 5' flanking region is TATA-less and contains a GC-rich region involved in cellular expression. PMID: 12530665
    23. differences in cellular response to gastric inhibitory polypeptide(GIP) mediated by endothelin-1 may be related to differences in activation of GIP receptor splice variants PMID: 12721154
    24. Glucose-stimulated insulin secretion is maintained despite complete absence of both GIP-1 and GIP receptors. Role for incretin receptors as essential downstream targets for glucoregulatory actions of DPP-IV inhibitors. PMID: 15111503
    25. Proximal promoter of GIP-R gene contains a GC-rich region capable of binding to Sp1 and SP3. PMID: 15666829
    26. the promoter region of the GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors PMID: 16087722
    27. GIPR adipose tissue gene expression was significantly lower in insulin resistant obese non-diabetic women PMID: 17395281
    28. GIPR overexpression was observed in pediatric and adult adrenocortical tumors PMID: 18971217
    29. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. PMID: 19211686
    30. Our data suggest a potential relevance of GIPR variants for obesity. PMID: 19254363
    31. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GLP-1R and GIP-R. PMID: 19386626

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 2 family
  • 數據庫鏈接:

    HGNC: 4271

    OMIM: 137241

    KEGG: hsa:2696

    STRING: 9606.ENSP00000467494

    UniGene: Hs.251412



主站蜘蛛池模板: 在线亚洲视频网站www色| 野外少妇愉情中文字幕| 国产精品久久久久久爽爽爽| 无码区日韩特区永久免费系列| 日本高清va在线播放| 久久精品日韩av无码| 日韩人妻无码精品二专区| 国模杨依粉嫩蝴蝶150p| 精品国产乱码久久久久久影片| 久久精品国产久精国产一老狼| 国产成人亚洲精品无码最新| 亚洲精品gv天堂无码男同| 男女啪啪永久免费观看网站| 久爱无码精品免费视频在线观看| 久久人人超碰精品caoporen| 久久精品国产日本波多野结衣| 亚洲精品无码永久在线观看性色| 直接观看黄网站免费视频| 亚洲精品国产美女久久久99| 国产又色又爽又刺激在线播放| 国产精品vr专区| 日本一区二区三区免费更新不卡| 国产丰满乱子伦无码专区| 欧美日韩一本的免费高清视频| 欧美大屁股熟妇bbbbbb| 奇米影视888欧美在线观看| 国产精品人妻久久毛片| 成人爽a毛片在线视频淮北| 国产乱色国产精品播放视频| 激情欧美日韩一区二区| 在线播放免费人成毛片乱码| 国产成人小说视频在线观看| 女子spa高潮呻吟抽搐| 欧美又粗又长又爽做受| 国内无遮挡18禁无码网站免费| 99国产揄拍国产精品人妻| 亚洲国产精品va在线看黑人| 色综合视频一区二区三区| 99尹人香蕉国产免费天天| 久久精品www人人做人人爽| 一本无码久本草在线中文字幕dvd|