在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GAS8 Antibody

GAS8 Antibody

  • 中文名稱：
    GAS8兔多克隆抗體
  • 貨號：
    CSB-PA593948
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA593948(GAS8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA593948(GAS8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GAS8
  • 別名：
    Growth arrest specific protein 8 antibody; MGC138326 antibody; GAS 11 antibody; GAS 8 antibody; GAS-11 antibody; GAS-8 antibody; GAS11 antibody; Gas8 antibody; GAS8_HUMAN antibody; Growth arrest specific 11 antibody; Growth arrest specific 8 antibody; Growth arrest specific protein 11 antibody; Growth arrest-specific protein 11 antibody; Growth arrest-specific protein 8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human GAS8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.
  • 基因功能參考文獻：
    1. In papillary thyroid carcinoma (PTC) cell lines, GAS8-AS1 inhibited proliferation, activated autophagy, and increased ATG5 expression. Downregulation of ATG5 reversed GAS8-AS1-mediated activation of autophagy leading to cell death, revealing a novel mechanism of the GAS8-AS1-ATG5 axis in PTC cell lines. PMID: 29327301
    2. Study identifies bi-allelic loss-of-function mutations in GAS8 as a cause for primary ciliary dyskinesia, and unveils the key importance of the protein encoded by this gene in N-DRC integrity and in the proper alignment of axonemal microtubules in humans. PMID: 27120127
    3. Here, we generate the first mouse with a Gas8 mutation and show that it causes severe Primary Ciliary Dyskinesia (PCD)phenotypes; however, there were no overt Hh pathway phenotypes. In addition, we identified two human patients with missense variants in Gas8 PMID: 27472056
    4. Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. PMID: 26387594
    5. A two-hybrid screen for proteins that interact with NS1 from influenza A yielded growth arrest-specific protein 8. Gas8 associated with NS1 in vitro and in vivo. PMID: 19995461

    顯示更多

    收起更多

  • 相關疾病：
    Ciliary dyskinesia, primary, 33 (CILD33)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme.
  • 蛋白家族：
    DRC4 family
  • 組織特異性：
    Expressed in respiratory epithelial cells (at protein level). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney.
  • 數據庫鏈接：

    HGNC: 4166

    OMIM: 605178

    KEGG: hsa:2622

    STRING: 9606.ENSP00000268699

    UniGene: Hs.431792



主站蜘蛛池模板： 熟妇人妻不卡中文字幕| 国产高清女同学巨大乳在线观看 | 香蕉久久福利院| 亚洲一区二区三区在线网址| 久久婷婷五月综合97色直播| 国产精品久久久久久av| 国精品99久9在线 | 免费| 亚洲卡1卡2卡新区网站| 欧美奶涨边摸边做爰视频| 国产熟妇乱子伦视频在线观看| 乱人伦视频中文字幕| 麻豆国产va免费精品高清在线| 人与禽交videos欧美| 国产精品禁18久久久夂久| 亚洲一区无码中文字幕| 兔费看少妇性l交大片免费| 国产精品喷浆| 人妻出差精油按摩被中出| av无码国产在线观看岛国| 日本精品少妇一区二区三区| 中文无码天天av天天爽| 国产又色又爽又黄的在线观看| 色偷偷尼玛图亚洲综合| 亚洲小说图区综合在线| 久久精品中文闷骚内射| 日本猛少妇色xxxxx猛叫| 国产精品亚洲а∨无码播放麻豆| 欧美黑人与白人精品a片| 无码一区二区三区av免费| 人妻精品无码一区二区三区| 伊人久久大香线蕉av网| 中文成人无码精品久久久动漫 | 熟女人妻aⅴ一区二区三区60路| 精品 在线 视频 亚洲| 国产精品高潮呻吟av久久男男| 人人妻人人爽人人澡av| 小辣椒福利视频导航| 国产乱人伦偷精品视频| 国产真实夫妇视频| 亚洲成av人片在线观看无| 亚洲伊人情人综合网站|