在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GAS8 Antibody

GAS8 Antibody

  • 中文名稱：
    GAS8兔多克隆抗體
  • 貨號：
    CSB-PA008697
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GAS8
  • 別名：
    Growth arrest specific protein 8 antibody; MGC138326 antibody; GAS 11 antibody; GAS 8 antibody; GAS-11 antibody; GAS-8 antibody; GAS11 antibody; Gas8 antibody; GAS8_HUMAN antibody; Growth arrest specific 11 antibody; Growth arrest specific 8 antibody; Growth arrest specific protein 11 antibody; Growth arrest-specific protein 11 antibody; Growth arrest-specific protein 8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Gas8.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.
  • 基因功能參考文獻：
    1. In papillary thyroid carcinoma (PTC) cell lines, GAS8-AS1 inhibited proliferation, activated autophagy, and increased ATG5 expression. Downregulation of ATG5 reversed GAS8-AS1-mediated activation of autophagy leading to cell death, revealing a novel mechanism of the GAS8-AS1-ATG5 axis in PTC cell lines. PMID: 29327301
    2. Study identifies bi-allelic loss-of-function mutations in GAS8 as a cause for primary ciliary dyskinesia, and unveils the key importance of the protein encoded by this gene in N-DRC integrity and in the proper alignment of axonemal microtubules in humans. PMID: 27120127
    3. Here, we generate the first mouse with a Gas8 mutation and show that it causes severe Primary Ciliary Dyskinesia (PCD)phenotypes; however, there were no overt Hh pathway phenotypes. In addition, we identified two human patients with missense variants in Gas8 PMID: 27472056
    4. Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. PMID: 26387594
    5. A two-hybrid screen for proteins that interact with NS1 from influenza A yielded growth arrest-specific protein 8. Gas8 associated with NS1 in vitro and in vivo. PMID: 19995461

    顯示更多

    收起更多

  • 相關疾病：
    Ciliary dyskinesia, primary, 33 (CILD33)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme.
  • 蛋白家族：
    DRC4 family
  • 組織特異性：
    Expressed in respiratory epithelial cells (at protein level). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney.
  • 數據庫鏈接：

    HGNC: 4166

    OMIM: 605178

    KEGG: hsa:2622

    STRING: 9606.ENSP00000268699

    UniGene: Hs.431792



主站蜘蛛池模板： 成人欧美一区二区三区在线| 国精产品999国精产品官网| 亚洲综合无码久久精品综合| 色偷拍 自怕 亚洲 10p| 国产孩cao大人xxxx| 麻花传媒mv国产免费观看视频| 好爽…又高潮了毛片免费看| 国内精品久久久久影院薰衣草| 国产午夜a理论毛片| 中文字幕无码日韩中文字幕| 无码人妻精一区二区三区| 人人爽人人爽人人片av| 久久久久久久波多野结衣高潮| 久久久久国产精品人妻aⅴ果冻 | 久久中文字幕人妻熟av女蜜柚m| 国产色产综合色产在线视频| 99re8精品视频热线观看| 久久综合狠狠综合久久激情| 国产精品久久久久久无毒不卡| 久久婷婷久久一区二区三区| 久久―日本道色综合久久| 人人爽人人爱| 男人扒开添女人下部免费视频| 最新国产aⅴ精品无码| 国产精品久久久久无码av1| 国产免费无遮挡吸乳视频| 女人18毛片水真多免费看| 2021年精品国产福利在线| 67194熟妇在线观看线路1| 国产v亚洲v天堂无码久久久 | 亚洲不乱码卡一卡二卡4卡5| 免费啪视频在线观看视频日本 | 特黄aaaaaaaaa毛片免费视频| 无码人妻精品一区二区三区不卡| 欧美成人精品三级网站视频| 国产精品videossex国产高清| 99视频在线精品免费观看6| 国模无码一区二区三区不卡| 五月综合激情婷婷六月色窝| 三男一女吃奶添下面视频| 成人免费午夜无码视频在线播放 |