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  4. GALR2 Antibody

GALR2 Antibody

  • 中文名稱：
    GALR2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA009224LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of A549 cells with CSB-PA009224LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GALR2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GALR2; GALNR2; Galanin receptor type 2; GAL2-R; GALR-2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Galanin receptor type 2 protein (282-387AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，GALR2 Antibody (CSB-PA009224LA01HU)，的標(biāo)記方式是Non-conjugated。對于GALR2 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA009224LB01HU GALR2 Antibody, HRP conjugated ELISA
    FITC CSB-PA009224LC01HU GALR2 Antibody, FITC conjugated
    Biotin CSB-PA009224LD01HU GALR2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
  • 基因功能參考文獻(xiàn)：
    1. Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
    2. GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
    3. The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer PMID: 24568968
    4. In HEp-2 cells, GALR2-mediated apoptosis was caspase-independent. PMID: 24168112
    5. Activation of GalR2 leads to elevation of intracellular Ca(2+) due to Ca(2+) efflux from endoplasmic reticulum through IP3R sequentially opening BK alpha channels. PMID: 24602615
    6. The expression of GALR2 mRNA is lost in head and neck squamous cell carcinoma as a consequence of DNA methylation.Silencing of the GALR2 gene by methylation may be a critical event in head and neck squamous cell carcinoma. PMID: 24122450
    7. galanin receptor 2 promotes cell proliferation and survival, and promotes tumor growth, consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck PMID: 21345369
    8. Elevated expression of galanin receptors in childhood neuroblastic tumors PMID: 11867941
    9. study indicates that a high level of GalR2 galanin receptor expression is able to inhibit cell proliferation and induce apoptosis in neuroblastoma cells PMID: 14592962
    10. There was no effect of GALR2 on alcoholism risk. PMID: 17083333
    11. point to GalR2 as a possible target for therapeuthic interventions in pheochromocytoma PMID: 18272487

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4133

    OMIM: 603691

    KEGG: hsa:8811

    STRING: 9606.ENSP00000329684

    UniGene: Hs.666366



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