在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GABBR2 Antibody

  • 中文名稱:
    GABBR2兔多克隆抗體
  • 貨號:
    CSB-PA080027
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    BcDNA:GH07312 antibody; CG6706 antibody; CT20836 antibody; D Gaba2 antibody; FLJ36928 antibody; G protein coupled receptor 51 antibody; G-protein coupled receptor 51 antibody; GAB B R2 antibody; GABA B R2 antibody; GABA B receptor 2 antibody; GABA-B receptor 2 antibody; GABA-B-R2 antibody; GABA-BR2 antibody; GABAB R2 antibody; GABABR 2 antibody; GABABR2 antibody; GABB R2 antibody; GABBR 2 antibody; Gabbr2 antibody; GABR2_HUMAN antibody; Gamma aminobutyric acid B receptor 2 antibody; Gamma aminobutyric acid GABA B receptor 2 antibody; Gamma aminobutyric acid type B receptor subunit 2 antibody; Gamma-aminobutyric acid type B receptor subunit 2 antibody; Gb 2 antibody; Gb2 antibody; GH07312 antibody; GPR 51 antibody; GPR51 antibody; GPRC 3B antibody; GPRC3B antibody; HG 20 antibody; HG20 antibody; HRIHFB2099 antibody; Metabotropic GABA B receptor subtype 2 antibody; OTTHUMP00000021776 antibody; OTTHUMP00000063797 antibody; R2 SUBUNIT antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human GABAB R2 around the non-phosphorylation site of S893.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
  • 基因功能參考文獻:
    1. GABA B receptor expression in myometrium PMID: 30343129
    2. We demonstrated that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma PMID: 28490462
    3. There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene. PMID: 28118741
    4. Missense Mutation in GABBR2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
    5. GABBR2 is a genetic factor that determines Rett syndrome- or epileptic encephalopathy-like phenotype expression depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes. PMID: 28856709
    6. Using a ligand-guided approach, eight GABAB2 homology models have been chosen as possible structural representatives of the transmembrane domain of the GABAB2 subunit. PMID: 28323850
    7. a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset. PMID: 27033668
    8. The rare variants in GABBR2 were significantly associated with smoking status. PMID: 25450229
    9. GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway. PMID: 24682435
    10. Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex. PMID: 24923912
    11. The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. PMID: 24778228
    12. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity PMID: 24482233
    13. and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities. PMID: 22169202
    14. Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. PMID: 22613715
    15. The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system. PMID: 22660477
    16. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes. PMID: 21971078
    17. Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit. PMID: 21724853
    18. The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders. PMID: 21303731
    19. GABA(B) receptor subunit 2 levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls. PMID: 20557420
    20. variants of GABBR1 and GABBR2 are associated with nicotine dependence in European- and African-American populations PMID: 19763258
    21. Increased expression of GABA(B) receptor subtype 2 indicates augmented presynaptic inhibition of glutamate release as a possible protective mechanism in temporal lobe epilepsy. PMID: 14625043
    22. GABA(B) receptor subunit GABA(B)R2 is found on the same neurons and follows the same distribution patterns in the basal ganglia as the GABABR1 receptor subunit. PMID: 14961561
    23. Association of the GABA(B)R1 with the GABA(A) receptor gamma2S subunit robustly promotes cell surface expression of GABA(B)R1 in the absence of GABA(B)R2, that is usually required for efficient trafficking of GABA(B)R1 to the cell surface. PMID: 14966130
    24. The GABA(B) receptor may be present as a heterodimer with subunits of GABA(B1) and GABA(B2) in the human colon. PMID: 14978362
    25. Functional GABA(B) receptors are expressed in human airway smooth muscle cells PMID: 16829628
    26. GABA(B) receptor stability and signaling can be modulated via GABA(B) receptor subunit 2 interactions with the PDZ scaffold protein Mupp1, which may contribute to cell-specific regulation of GABA(B) receptors in the central nervous system. PMID: 17145756
    27. Levels of GABBR1 are significantly decreased in the cerebellum of patients with autism. PMID: 19002745

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 3 family, GABA-B receptor subfamily
  • 組織特異性:
    Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in hear
  • 數據庫鏈接:

    HGNC: 4507

    OMIM: 607340

    KEGG: hsa:9568

    STRING: 9606.ENSP00000259455

    UniGene: Hs.198612



主站蜘蛛池模板: 欧美精品18videos性欧美| 日本道色综合久久影院| 中文 在线 日韩 亚洲 欧美| 亚洲一区二区三区无码av| 中国精学生妹品射精久久| 国内精品人妻久久毛片app| 中文字幕一区二区三区精华液| 亚洲这里只有久热精品伊人| 国产成 人 综合 亚洲网站| 男人边吃奶边做好爽免费视频| 无码日韩精品一区二区人妻| 日本不卡三区| 暖暖视频 免费 日本社区| 成人精品v视频在线| 欧美激情综合五月色丁香| 色欲aⅴ亚洲情无码av蜜桃| 亚洲国产综合在线观看不卡| 日韩一区精品视频一区二区| 亚洲成av人片久久| 一本一道精品欧美中文字幕| 天天综合网久久综合免费人成| 免费的av网站手机版| а天堂中文在线官网| 美女扒开尿口让男人桶| 午夜成人影院网站18进| 久久国产加勒比精品无码| 全黄性性激高免费视频| 色欲久久人妻内射| 国产亚洲日韩av在线播放不卡 | 韩国日本三级在线观看| 97色偷偷色噜噜狠狠爱网站97| 日韩成人无码v清免费| 18女下面流水不遮图| 天天射寡妇射| 精品成人免费国产片| 米奇影院888奇米色99在线| 亚洲精品无amm毛片| 色偷偷av男人的天堂| 欧美一道本一区二区三区| 婷婷成人五月综合激情| 色77久久综合网|