在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GABBR2 Antibody

  • 中文名稱:
    GABBR2兔多克隆抗體
  • 貨號:
    CSB-PA009135ESR1HU
  • 規(guī)格:
    ¥440
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GABBR2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BcDNA:GH07312 antibody; CG6706 antibody; CT20836 antibody; D Gaba2 antibody; FLJ36928 antibody; G protein coupled receptor 51 antibody; G-protein coupled receptor 51 antibody; GAB B R2 antibody; GABA B R2 antibody; GABA B receptor 2 antibody; GABA-B receptor 2 antibody; GABA-B-R2 antibody; GABA-BR2 antibody; GABAB R2 antibody; GABABR 2 antibody; GABABR2 antibody; GABB R2 antibody; GABBR 2 antibody; Gabbr2 antibody; GABR2_HUMAN antibody; Gamma aminobutyric acid B receptor 2 antibody; Gamma aminobutyric acid GABA B receptor 2 antibody; Gamma aminobutyric acid type B receptor subunit 2 antibody; Gamma-aminobutyric acid type B receptor subunit 2 antibody; Gb 2 antibody; Gb2 antibody; GH07312 antibody; GPR 51 antibody; GPR51 antibody; GPRC 3B antibody; GPRC3B antibody; HG 20 antibody; HG20 antibody; HRIHFB2099 antibody; Metabotropic GABA B receptor subtype 2 antibody; OTTHUMP00000021776 antibody; OTTHUMP00000063797 antibody; R2 SUBUNIT antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Gamma-aminobutyric acid type B receptor subunit 2 protein (60-310AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
  • 基因功能參考文獻:
    1. GABA B receptor expression in myometrium PMID: 30343129
    2. We demonstrated that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma PMID: 28490462
    3. There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene. PMID: 28118741
    4. Missense Mutation in GABBR2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
    5. GABBR2 is a genetic factor that determines Rett syndrome- or epileptic encephalopathy-like phenotype expression depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes. PMID: 28856709
    6. Using a ligand-guided approach, eight GABAB2 homology models have been chosen as possible structural representatives of the transmembrane domain of the GABAB2 subunit. PMID: 28323850
    7. a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset. PMID: 27033668
    8. The rare variants in GABBR2 were significantly associated with smoking status. PMID: 25450229
    9. GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway. PMID: 24682435
    10. Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex. PMID: 24923912
    11. The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. PMID: 24778228
    12. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity PMID: 24482233
    13. and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities. PMID: 22169202
    14. Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. PMID: 22613715
    15. The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system. PMID: 22660477
    16. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes. PMID: 21971078
    17. Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit. PMID: 21724853
    18. The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders. PMID: 21303731
    19. GABA(B) receptor subunit 2 levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls. PMID: 20557420
    20. variants of GABBR1 and GABBR2 are associated with nicotine dependence in European- and African-American populations PMID: 19763258
    21. Increased expression of GABA(B) receptor subtype 2 indicates augmented presynaptic inhibition of glutamate release as a possible protective mechanism in temporal lobe epilepsy. PMID: 14625043
    22. GABA(B) receptor subunit GABA(B)R2 is found on the same neurons and follows the same distribution patterns in the basal ganglia as the GABABR1 receptor subunit. PMID: 14961561
    23. Association of the GABA(B)R1 with the GABA(A) receptor gamma2S subunit robustly promotes cell surface expression of GABA(B)R1 in the absence of GABA(B)R2, that is usually required for efficient trafficking of GABA(B)R1 to the cell surface. PMID: 14966130
    24. The GABA(B) receptor may be present as a heterodimer with subunits of GABA(B1) and GABA(B2) in the human colon. PMID: 14978362
    25. Functional GABA(B) receptors are expressed in human airway smooth muscle cells PMID: 16829628
    26. GABA(B) receptor stability and signaling can be modulated via GABA(B) receptor subunit 2 interactions with the PDZ scaffold protein Mupp1, which may contribute to cell-specific regulation of GABA(B) receptors in the central nervous system. PMID: 17145756
    27. Levels of GABBR1 are significantly decreased in the cerebellum of patients with autism. PMID: 19002745

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 3 family, GABA-B receptor subfamily
  • 組織特異性:
    Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in hear
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4507

    OMIM: 607340

    KEGG: hsa:9568

    STRING: 9606.ENSP00000259455

    UniGene: Hs.198612



主站蜘蛛池模板: 国产精品福利视频一区| 可以免费观看的av毛片下载| 日本爽爽爽爽爽爽在线观看免| 播放男人添女人下边视频| 亚洲精品乱码久久久久红杏| 玩弄放荡人妇系列av在线网站| 超清制服丝袜无码av福利网| 国产很色很黄很大爽的视频| 美女内射毛片在线看3d| 国产成人精品亚洲午夜麻豆| 亚洲综合国产一区二区三区| 日本中文字幕乱码aa高清电影| 欧美40老熟妇色xxxxx| 人妻少妇中文字幕乱码| 欧美mv日韩mv国产网站app| 国产精品无码av片在线观看播| 亚洲精品午夜一区人人爽| 少妇高潮喷水惨叫久久久久电影| 亚洲另类春色校园小说| 特级无码毛片免费视频播放▽| 婷婷四虎东京热无码群交双飞视频 | 亚洲无日韩码精品| 在线 | 国产精品星空传媒丿| 小妖精又紧又湿高潮h视频69| 午夜性开放午夜性爽爽| 亚洲精品午夜理伦不卡在线观看 | 日产精品99久久久久久| 377人体粉嫩噜噜噜| 中国凸偷窥xxxx自由视频妇科| 日本黄网站三级三级三级| 鲁鲁夜夜天天综合视频| 浪潮av激情高潮国产精品| 国产 在线 | 日韩| 亚洲 自拍 色综合图区av| 国产卡一卡二无线乱码| 亚洲 欧美 国产 日韩 精品| 亚洲中文字幕精品久久| 久热中文字幕无码视频| 天堂网在线观看| 精品久久久噜噜噜久久久| 色欲久久综合亚洲精品蜜桃|