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G0S2 Antibody, Biotin conjugated

  • 中文名稱:
    G0S2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA009114ED01HU
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) G0S2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    G0S2
  • 別名:
    G0/G1 switch regulatory protein 2 antibody; G0/G1switch 2 antibody; G0s2 antibody; G0S2_HUMAN antibody; OTTHUMP00000034644 antibody; Putative lymphocyte G0/G1 switch protein 2 antibody; RP1 28O10.2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human G0/G1 switch protein 2 protein (1-103AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
  • 基因功能參考文獻:
    1. ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen PMID: 28910567
    2. Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPbeta-mediated G0S2 expression. PMID: 29209111
    3. G0S2 functions as a master regulator of tissue-specific balance of TG storage vs. mobilization, partitioning of metabolic fuels between adipose and liver, and the whole-body adaptive energy response. PMID: 28645852
    4. PML/RARalpha synergizes with C/EBPepsilon to reactivate the C/EBPepsilon target G0S2, thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia differentiation and potentially, clinical remission. PMID: 27605212
    5. differences in G0S2 expression may explain depot-specific and obesity-associated differences in lipolysis on the molecular level PMID: 26707160
    6. Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL). PMID: 26318046
    7. Results indicate that G0S2 acts as a prosurvival molecule in endothelial cells. PMID: 25588877
    8. Data indicate that the peptide corresponding to residues Lys-20 to Ala-52 from G0S2 Inhibits ATGL in the nanomolar range. PMID: 25258314
    9. reelin expression is altered by Abeta leading to impaired reelin signaling. PMID: 23951308
    10. A new mechanism that controls proliferation in K562 cells, suggesting a possible tumor suppressor function for G0S2 in leukemia cells. PMID: 24183236
    11. This linked G0S2 subcellular localization to G0S2 transcriptional repression. The potential mechanisms responsible for this G0S2 repression are examined. PMID: 23546556
    12. Data indicate that downregulation of G0S2 in adipose tissue could represent one of the underlying causes leading to increased lipolysis in the insulin-resistant state. PMID: 22891293
    13. Gene expression profiles showed that G0/G1 switch 2 was up-regulated in epidermolysis bullosa subtypes. PMID: 22716248
    14. Reduced mRNA and protein content of Plin and G0S2 and borderline increased ATGL protein in sc adipose tissue from poorly controlled type 2 diabetic subjects. PMID: 22535977
    15. findings are compatible with the notion that the ATGL-G0S2 complex is an important long-term regulator of lipolysis under physiological conditions such as fasting in humans PMID: 21613358
    16. DNA methylation of G0S2 can be an important biomarker for squamous lung cancer. PMID: 19816938
    17. mRNA expression of G0S2 was regulated mainly by DNA methylation in squamous lung cancer cell lines. PMID: 19878646
    18. A novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2) was identified and characterized. PMID: 16086669
    19. G0S2 is an all-trans-retinoic acid target gene PMID: 18636162
    20. G0S2 encodes a mitochondrial protein that specifically interacts with Bcl-2 and promotes apoptosis by preventing the formation of protective Bcl-2/Bax heterodimers PMID: 19706769

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  • 亞細胞定位:
    Mitochondrion.
  • 組織特異性:
    Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30229

    OMIM: 614447

    KEGG: hsa:50486

    STRING: 9606.ENSP00000355996

    UniGene: Hs.432132



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