在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FRK Antibody

FRK Antibody

  • 中文名稱：
    FRK兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008988GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    FRK
  • 別名：
    Beta cell Src homology tyrosine kinase antibody; BSK antibody; BSK/IYK antibody; C85044 antibody; Frk antibody; Frk fyn related kinase antibody; FRK_HUMAN antibody; FYN related kinase antibody; FYN-related kinase antibody; GASK antibody; Gastrointestinal associated kinase antibody; Gastrointestinal associated tyrosine kinase antibody; GTK antibody; GTK; mouse; homolog of antibody; Intestine tyrosine kinase antibody; Nuclear tyrosine protein kinase RAK antibody; Protein-tyrosine kinase 5 antibody; PTK5 antibody; PTK5 protein tyrosine kinase 5 antibody; RAK antibody; Tyrosine protein kinase FRK antibody; Tyrosine-protein kinase FRK antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FRK
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. our results present the first evidence that site-specific promoter methylation contributes to the repression of FRK more so in basal B breast cancers. PMID: 28077797
    2. Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer. PMID: 27665472
    3. antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. PMID: 25783528
    4. our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells. PMID: 24792491
    5. FRK over-expression promoted beta-catenin translocation to the plasma membrane, where it formed complex with N-cadherin. PMID: 24969324
    6. exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors PMID: 24735922
    7. Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction. PMID: 23318459
    8. The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines. PMID: 23267173
    9. these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion PMID: 22790444
    10. Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. PMID: 21665990
    11. Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs. PMID: 21074287
    12. Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase PMID: 12569567
    13. The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct. PMID: 12725532
    14. Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference. PMID: 15082191
    15. Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. PMID: 19345329

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
  • 組織特異性：
    Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3955

    OMIM: 606573

    KEGG: hsa:2444

    STRING: 9606.ENSP00000357615

    UniGene: Hs.89426



主站蜘蛛池模板： 亚洲精品自偷自拍无码| 久久aaaa片一区二区| 国产l精品国产亚洲区久久| 美女极度色诱视频国产免费| 中文字幕精品视频在线看免费 | 国产麻豆一精品一av一免费 | 成 人 综合 亚洲另类| 欧美乱人伦视频在线| 亚洲中文字幕无码久久| 亚洲欧美一区二区三区日产| 午夜在线a亚洲v天堂网2018| 又粗又硬又黄又爽的视频永久| 乌克兰少妇xxxx做受野外| 国产精品自在线拍国产电影| 国产揄拍国产精品| 精品亚洲成av人在线观看| 久久偷看各类wc女厕嘘嘘| 香蕉av福利精品导航| 久久伊99综合婷婷久久伊| 男人把女人桶到爽免费应用| 久久精品国产丝袜人妻| 欧美成人精品a∨在线观看| 性中国妓女毛茸茸视频| 色婷婷六月亚洲综合香蕉| 中国国语毛片免费观看视频| 国产在线无码制服丝袜无码| 久久激情五月丁香伊人| 人妻熟女一区| 国产美女被遭高潮免费视频| 美女视频黄又黄又免费| 欧美丰满熟妇bbb久久久| 欧美人与动牲交xxxxbbbb| av毛片无码中文字幕不卡| 粉嫩极品国产在线观看| 精品国产乱码久久久久久浪潮| 激情综合激情五月俺也去| 99久热国产精品视频尤物| 午夜精品久久久久久久| 国内精品久久久久久久影视| 97国产在线看片免费人成视频| 又色又爽又黄18禁美女裸身无遮挡|