在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FRK Antibody

  • 中文名稱:
    FRK兔多克隆抗體
  • 貨號:
    CSB-PA237384
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells, using FRK antibody.
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using FRK antibody.
    • Immunofluorescence analysis of HUVEC cells, using FRK antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FRK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FRK
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human FRK.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
  • 基因功能參考文獻:
    1. our results present the first evidence that site-specific promoter methylation contributes to the repression of FRK more so in basal B breast cancers. PMID: 28077797
    2. Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer. PMID: 27665472
    3. antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. PMID: 25783528
    4. our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells. PMID: 24792491
    5. FRK over-expression promoted beta-catenin translocation to the plasma membrane, where it formed complex with N-cadherin. PMID: 24969324
    6. exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors PMID: 24735922
    7. Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction. PMID: 23318459
    8. The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines. PMID: 23267173
    9. these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion PMID: 22790444
    10. Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. PMID: 21665990
    11. Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs. PMID: 21074287
    12. Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase PMID: 12569567
    13. The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct. PMID: 12725532
    14. Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference. PMID: 15082191
    15. Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. PMID: 19345329

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
  • 組織特異性:
    Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
  • 數據庫鏈接:

    HGNC: 3955

    OMIM: 606573

    KEGG: hsa:2444

    STRING: 9606.ENSP00000357615

    UniGene: Hs.89426



主站蜘蛛池模板: 国产成人无码午夜视频在线观看| 少妇和邻居做不戴套视频| 无码国内精品久久人妻蜜桃| 麻豆专媒体一区二区| 丰满少妇熟女高潮流白浆| 黑人大荫蒂老太大| 美女露出奶头扒开尿口免费网站| 久久精品国产久精国产一老狼| 亚洲 另类 在线 欧美 制服| 久久不见久久见免费视频1′| 久久99热久久99精品| 中文字幕人成乱码熟女| 国精产品一区二区三区| 精品午夜福利在线视在亚洲| 中文字幕在线不卡精品视频99| 狠狠色色综合网站| 国产 | 久你欧洲野花视频欧洲1| 四虎国产成人永久精品免费| 亚洲人成网站在线播放影院在线| 四虎国产精品永久地址入口| 特级毛片a片久久久久久| 福利姬液液酱喷水| 久章草在线精品视频免费观看 | 在线播放国产精品三级| 人妻少妇中文字幕久久| 国产精品久久久久久亚洲影视| 久久久久四虎精品免费入口| 久久精品亚洲精品无码| 国内精品久久毛片一区二区| 国产无线乱码一区二三区| 日产精品卡1卡2卡三卡在线| 国产欧美另类久久久精品不卡| 色偷偷偷在线视频播放| 国产动作大片中文字幕| av一区二区三区人妻少妇| 国产制服日韩丝袜86页| 后入到高潮免费观看| 狠狠躁日日躁夜夜躁2022麻豆| 中文字幕一区二区精品区| 丰满岳妇乱一区二区三区| 青青国产线免观|