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  4. FOXN1 Antibody

FOXN1 Antibody

  • 中文名稱：
    FOXN1兔多克隆抗體
  • 貨號：
    CSB-PA008829LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Raji whole cell lysate, Mouse lung tissue, Mouse stomach tissue
      All lanes: FOXN1 antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 69 kDa
      Observed band size: 69 kDa
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA008829LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA008829LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品描述：

    The FOXN1 antibody (CSB-PA008829LA01HU) is a polyclonal antibody raised in rabbits immunized with a peptide mapping within amino acids 1-160 of the recombinant human FOXN1. It exists as an unconjugated IgG. Its purity is greater than 95% using protein G purified. And it is reactive with human and mouse FOXN1 protein, a transcription factor involved in the formation of the thymus. Dysfunction of FOXN1 leads to a severe T cell developmental block due to thymic agenesis and is also related to alopecia and nail dystrophy. This FOXN1 antibody has been validated for use in ELISA, WB, and IHC applications.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FOXN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FOXN1
  • 別名：
    FKHL20 antibody; Forkhead box N1 antibody; Forkhead box protein N1 antibody; FOXN 1 antibody; FOXN1 antibody; FOXN1_HUMAN antibody; RONU antibody; Rowett nude antibody; Transcription factor winged-helix nude antibody; WHN antibody; Winged helix nude antibody; Winged-helix transcription factor nude antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Forkhead box protein N1 protein (1-160AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，FOXN1 Antibody (CSB-PA008829LA01HU)，的標記方式是Non-conjugated。對于FOXN1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA008829LB01HU FOXN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA008829LC01HU FOXN1 Antibody, FITC conjugated
    Biotin CSB-PA008829LD01HU FOXN1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C. Plays a crucial role in the early prenatal stages of T-cell ontogeny.
  • 基因功能參考文獻：
    1. FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency. PMID: 28636882
    2. Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders. PMID: 26352270
    3. Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency in a female infant is reported. PMID: 25173801
    4. These results show that miR-18b and miR-518b are upstream controllers of FOXN1-directed epithelial lineage development. PMID: 24383669
    5. The retinoid-related orphan receptor RORalpha promotes keratinocyte differentiation via FOXN1. PMID: 23922987
    6. This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. PMID: 22721479
    7. results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation PMID: 21507891
    8. role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review] PMID: 20429426
    9. study uncovered a positive regulatory loop between FGFR3 and FOXN1 that underlies a benign versus malignant skin tumor phenotype PMID: 19729838
    10. Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency associated with alopecia PMID: 15180707
    11. These results establish a role for FOXN1 in initiation of terminal differentiation and implicate Akt in subsequent events. PMID: 15316080
    12. Mechanisms and signaling pathways by which Foxn1 modulates keratinocyte differentiation in hair follicle and nail apparatus. Molecular and functional consequences of loss of function of Foxn1 protein in skin. Review. PMID: 16232301
    13. Foxn1 is a sensitive and specific marker for thymoma and thymic carcinoma. PMID: 17592270
    14. Foxn1/FGF2 pathway involved in instructing melanocytes where to place pigment. PMID: 17803914

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  • 相關疾病：
    T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND)
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in thymus.
  • 數據庫鏈接：

    HGNC: 12765

    OMIM: 600838

    KEGG: hsa:8456

    STRING: 9606.ENSP00000226247

    UniGene: Hs.58611



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