在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FOXN1 Antibody

FOXN1 Antibody

  • 中文名稱：
    FOXN1兔多克隆抗體
  • 貨號：
    CSB-PA966011
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA966011(FOXN1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    FOXN1
  • 別名：
    FKHL20 antibody; Forkhead box N1 antibody; Forkhead box protein N1 antibody; FOXN 1 antibody; FOXN1 antibody; FOXN1_HUMAN antibody; RONU antibody; Rowett nude antibody; Transcription factor winged-helix nude antibody; WHN antibody; Winged helix nude antibody; Winged-helix transcription factor nude antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human FOXN1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C. Plays a crucial role in the early prenatal stages of T-cell ontogeny.
  • 基因功能參考文獻(xiàn)：
    1. FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency. PMID: 28636882
    2. Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders. PMID: 26352270
    3. Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency in a female infant is reported. PMID: 25173801
    4. These results show that miR-18b and miR-518b are upstream controllers of FOXN1-directed epithelial lineage development. PMID: 24383669
    5. The retinoid-related orphan receptor RORalpha promotes keratinocyte differentiation via FOXN1. PMID: 23922987
    6. This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. PMID: 22721479
    7. results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation PMID: 21507891
    8. role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review] PMID: 20429426
    9. study uncovered a positive regulatory loop between FGFR3 and FOXN1 that underlies a benign versus malignant skin tumor phenotype PMID: 19729838
    10. Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency associated with alopecia PMID: 15180707
    11. These results establish a role for FOXN1 in initiation of terminal differentiation and implicate Akt in subsequent events. PMID: 15316080
    12. Mechanisms and signaling pathways by which Foxn1 modulates keratinocyte differentiation in hair follicle and nail apparatus. Molecular and functional consequences of loss of function of Foxn1 protein in skin. Review. PMID: 16232301
    13. Foxn1 is a sensitive and specific marker for thymoma and thymic carcinoma. PMID: 17592270
    14. Foxn1/FGF2 pathway involved in instructing melanocytes where to place pigment. PMID: 17803914

    顯示更多

    收起更多

  • 相關(guān)疾病：
    T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND)
  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in thymus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12765

    OMIM: 600838

    KEGG: hsa:8456

    STRING: 9606.ENSP00000226247

    UniGene: Hs.58611



主站蜘蛛池模板： 又湿又紧又大又爽又a视频| 欧美顶级metart裸体全部自慰| 免费无码不卡中文字幕在线| 婷婷综合缴情亚洲狠狠| 美女又色又爽视频免费| 国产成人a亚洲精v品无码| 亚洲精品自在在线观看| 日韩精品乱码av一区二区| 亚洲日韩欧美国产另类综合| 亚洲精品久久久久一区二区三区| 人人妻人人澡人人爽久久av| 亚洲综合色丁香婷婷六月图片| 国产精品sm捆绑调教视频| 国产亚洲精品欧洲在线观看| 少妇高潮一区二区三区99| 精品无人乱码一区二区三区的特点| 亚洲国产成人久久综合同性| 亚洲成 人 综合 亚洲欧洲| 国产精品久久久久久久久久久久午夜片 | 秋霞午夜成人久久电影网| 亚洲一区无码中文字幕乱码| 中文国产成人精品久久久| 国产白嫩护士被弄高潮| 国产精品久久久久久久久久久不卡 | 国产亚洲日韩在线a不卡| 人妻少妇精品中文字幕av蜜桃| 国产绳艺sm调教室论坛 | 人妻少妇邻居少妇好多水在线| 久久久久久无码精品人妻a片软件 999久久久精品国产消防器材 | 国产边摸边吃奶边做爽视频| 手机在线亚洲国产精品| 亚洲 a v无 码免 费 成 人 a v | 18禁止看的免费污网站| 99国产精品白浆在线观看免费| 中文字幕无码日韩欧免费软件| 中美日韩毛片免费播放| 激情综合一区二区三区| 1000部精品久久久久久久久| 亚洲乱码日产精品bd| 永久免费观看国产裸体美女| 国产成人精品日本亚洲77上位|