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FKBPL Antibody

  • 中文名稱：
    FKBPL兔多克隆抗體
  • 貨號(hào)：
    CSB-PA883441ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA883441ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA883441ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FKBPL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FKBPL
  • 別名：
    DIR1 antibody; FK506 binding protein like antibody; FK506-binding protein-like antibody; Fkbpl antibody; FKBPL_HUMAN antibody; NG7 antibody; OTTHUMP00000029170 antibody; WAF 1/CIP1 stabilizing protein 39 antibody; WAF-1/CIP1 stabilizing protein 39 antibody; WISP39 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human FK506-binding protein-like protein (1-349AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.
  • 基因功能參考文獻(xiàn)：
    1. This study identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 x 10-5) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 x 10-5) associated with breast cancer risk. PMID: 27479355
    2. The data suggests a role for FKBPL as a prognostic factor for BCSS, with the potential to be routinely evaluated within the clinic. PMID: 25906750
    3. WISp39 preferentially interacts with phosphorylated Coronin 1B, allowing it to complex with Slingshot phosphatase to dephosphorylate and activate Cofilin. PMID: 25800056
    4. FKBPL is an important regulator of developmental and pathological angiogenesis. PMID: 25767277
    5. high levels of FKBPL and RBCK1 correlated with increased patient survival, whereas high RBCK1 predicted for a poor response to tamoxifen. PMID: 23912458
    6. FKBPL and and its peptide derivative, AD-01 regulate expression of CD44. PMID: 23457460
    7. Genome-wide association study of age-related macular degeneration identifies TNXB, FKBPL and NOTCH4 as candidate susceptibility genes. PMID: 22694956
    8. Alterations in the gene for FKBPL in azoospermic patients. PMID: 20210997
    9. Findings suggest that FKBPL may have prognostic value based on its impact on tumor proliferative capacity and sensitivity to endocrine therapies, which improve outcome. PMID: 20103631
    10. Results demonstrate the importance of posttranslational stabilization of p21 protein by WISp39 in regulating cellular p21 activity. PMID: 15664193
    11. FKBPL can be classed as a new member of the FKBP protein family with a role in steroid receptor complexes and signaling. PMID: 18669603

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  • 組織特異性：
    Ubiquitously expressed with higher levels in testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13949

    KEGG: hsa:63943

    STRING: 9606.ENSP00000364298

    UniGene: Hs.520042



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