在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FKBP14 Antibody, HRP conjugated

  • 中文名稱:
    FKBP14兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA865159LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FKBP14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FKBP14
  • 別名:
    22 kDa FK506 binding protein antibody; 22 kDa FK506-binding protein antibody; 22 kDa FKBP antibody; FK506 binding protein 14 (22 kDa) antibody; FK506 binding protein 14 antibody; FK506-binding protein 14 antibody; FKB14_HUMAN antibody; FKBP 22 antibody; FKBP-14 antibody; FKBP-22 antibody; FKBP14 antibody; FKBP22 antibody; FLJ20731 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP14 antibody; PPIase antibody; PPIase FKBP14 antibody; Rotamase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP14 protein (20-211AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens.
  • 基因功能參考文獻:
    1. FKBP14 may act as an oncogene through suppressing apoptosis and promoting motility in human cervical carcinogenesis. PMID: 28731139
    2. Genetic studies showed that the patient harboured a homozygous mutation (c.362dupC p.Glu122Argfs*7) in the FKBP14 gene, confirming kyphoscoliotic EDS related to this gene. PMID: 27905128
    3. FKBP14 may act as an oncogene in osteosarcoma via suppressing apoptosis and promoting invasion and adhesion in osteosarcoma carcinogenesis PMID: 27223089
    4. this report describes a potentially life-threatening vascular complication in early pediatric age and atlantoaxial instability, suggesting the need for FKBP14-related EDS patients of tailored follow-up that includes cardiovascular monitoring, that is, cerebral, thoracic and abdominal MRA, and cervical dynamic radiograph. PMID: 27149304
    5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. PMID: 28385890
    6. FKBP14 expression was elevated in ovarian cancer tissues when compared with matched normal tissues. Lentiviral shRNA mediated knockdown of FKBP14 and suppressed the growth of ovarian cancer cells via arresting the cell cycle in the G0/G1 phase and stimulating cell apoptosis. Moreover, cell apoptosis induced by FKBP14 RNAi was mediated by enhancing the ratio of Bax/Bcl-2. PMID: 27131312
    7. Reduced expression of FKBP14 markedly impaired the proliferative ability of ovarian cancer cells. Additionally, ovarian cancer cells infected with FKBP14 shRNA lentivirus tended to arrest in the G0/G1 phase and undergo apoptosis. PMID: 27931282
    8. the occurrence of umbilical skin redundancy in association with two other syndromes: Morquio syndrome and FKBP14-related Ehlers-Danlos syndrome (EDS), is reported. PMID: 24773188
    9. FKBP22 catalyzes the folding of type III collagen and only interacts with type III type VI and type X collagen. PMID: 24821723
    10. A 1.9 A resolution crystal structure for human FKBP22 has been determined. The EF-hand motifs of two FKBP22 molecules form a dimeric complex with an elongated and predominantly hydrophobic cavity that can potentially be occupied by an aliphatic ligand. PMID: 24272907
    11. study demonstrated FKBP14 is localized in the endoplasmic reticulum (ER) and that deficiency of FKBP14 leads to enlarged ER cisterns in dermal fibroblasts in vivo. PMID: 22265013

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Ehlers-Danlos syndrome, with progressive kyphoscoliosis, myopathy, and hearing loss (EDSKMH)
  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18625

    OMIM: 614505

    KEGG: hsa:55033

    STRING: 9606.ENSP00000222803

    UniGene: Hs.390838



主站蜘蛛池模板: 天堂网在线www中文| 99热这里只就有精品22| 欧美极p品少妇的xxxxx| 国产午夜三级一区二区三| 奇米四色7777中文字幕| 亚洲午夜精品a片一区二区app| 亚洲老熟女性亚洲| 中文字幕在线免费看线人| 一线二线无人区乱码| 天堂网在线www资源| 久久国产成人精品av| 亚洲日本一区二区一本一道| 国产综合精品久久丫| 男生白内裤自慰gv白袜男同| 人妻va精品va欧美va| 伊人色综合久久天天五月婷| 无码免费毛片手机在线| 无码人妻精品一区二区三区下载 | 人妻体内射精一区二区三四| 和岳每晚弄的高潮嗷嗷叫视频| 肉感饱满中年熟妇日本| 中文字幕一区二区三区久久网站 | 无码人妻熟妇av又粗又大| 丝袜无码一区二区三区| 国产亚洲日本精品无码| 99久久免费国产精精品| 亚洲色欲久久久久综合网| 在线不卡日本v二区到六区| 无码日日模日日碰夜夜爽| 亚洲人成网站色7799| 装睡被陌生人摸出水好爽| 天天综合色天天综合色h| 亚洲а∨天堂男人色无码| 国产精品自在线拍国产手机版| 综合在线 亚洲 成人 欧美| 亚洲欧美中文高清在线专区| 亚洲色欲综合一区二区三区 | 国产超薄肉色丝袜视频| 玩弄放荡人妻少妇系列| 国产日韩在线时看高清视频 | 小宝贝荡货啊用力水湿aⅴ视频|