在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FKBP14 Antibody, FITC conjugated

  • 中文名稱:
    FKBP14兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA865159LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FKBP14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FKBP14
  • 別名:
    22 kDa FK506 binding protein antibody; 22 kDa FK506-binding protein antibody; 22 kDa FKBP antibody; FK506 binding protein 14 (22 kDa) antibody; FK506 binding protein 14 antibody; FK506-binding protein 14 antibody; FKB14_HUMAN antibody; FKBP 22 antibody; FKBP-14 antibody; FKBP-22 antibody; FKBP14 antibody; FKBP22 antibody; FLJ20731 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP14 antibody; PPIase antibody; PPIase FKBP14 antibody; Rotamase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP14 protein (20-211AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens.
  • 基因功能參考文獻:
    1. FKBP14 may act as an oncogene through suppressing apoptosis and promoting motility in human cervical carcinogenesis. PMID: 28731139
    2. Genetic studies showed that the patient harboured a homozygous mutation (c.362dupC p.Glu122Argfs*7) in the FKBP14 gene, confirming kyphoscoliotic EDS related to this gene. PMID: 27905128
    3. FKBP14 may act as an oncogene in osteosarcoma via suppressing apoptosis and promoting invasion and adhesion in osteosarcoma carcinogenesis PMID: 27223089
    4. this report describes a potentially life-threatening vascular complication in early pediatric age and atlantoaxial instability, suggesting the need for FKBP14-related EDS patients of tailored follow-up that includes cardiovascular monitoring, that is, cerebral, thoracic and abdominal MRA, and cervical dynamic radiograph. PMID: 27149304
    5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. PMID: 28385890
    6. FKBP14 expression was elevated in ovarian cancer tissues when compared with matched normal tissues. Lentiviral shRNA mediated knockdown of FKBP14 and suppressed the growth of ovarian cancer cells via arresting the cell cycle in the G0/G1 phase and stimulating cell apoptosis. Moreover, cell apoptosis induced by FKBP14 RNAi was mediated by enhancing the ratio of Bax/Bcl-2. PMID: 27131312
    7. Reduced expression of FKBP14 markedly impaired the proliferative ability of ovarian cancer cells. Additionally, ovarian cancer cells infected with FKBP14 shRNA lentivirus tended to arrest in the G0/G1 phase and undergo apoptosis. PMID: 27931282
    8. the occurrence of umbilical skin redundancy in association with two other syndromes: Morquio syndrome and FKBP14-related Ehlers-Danlos syndrome (EDS), is reported. PMID: 24773188
    9. FKBP22 catalyzes the folding of type III collagen and only interacts with type III type VI and type X collagen. PMID: 24821723
    10. A 1.9 A resolution crystal structure for human FKBP22 has been determined. The EF-hand motifs of two FKBP22 molecules form a dimeric complex with an elongated and predominantly hydrophobic cavity that can potentially be occupied by an aliphatic ligand. PMID: 24272907
    11. study demonstrated FKBP14 is localized in the endoplasmic reticulum (ER) and that deficiency of FKBP14 leads to enlarged ER cisterns in dermal fibroblasts in vivo. PMID: 22265013

    顯示更多

    收起更多

  • 相關疾病:
    Ehlers-Danlos syndrome, with progressive kyphoscoliosis, myopathy, and hearing loss (EDSKMH)
  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18625

    OMIM: 614505

    KEGG: hsa:55033

    STRING: 9606.ENSP00000222803

    UniGene: Hs.390838



主站蜘蛛池模板: 97久久久人妻一区精品| 一边摸一边抽搐一进一出视频| 2021无码最新国产在线观看| 日本成熟老妇乱| 国产午夜精品一区二区三区漫画 | 久久tv中文字幕首页| 国产成人欧美日韩在线电影 | 曰的好深好爽免费视频网站| 少妇被又大又粗又爽毛片久久黑人 | 日本国产一区二区三区在线观看| 小泽玛利亚一区二区在线观看| 欧美午夜特黄aaaaaa片| 人与狗精品aa毛片| 一区二区三区四区在线不卡高清| 无码专区久久综合久中文字幕| 老外和中国女人毛片免费视频| 国产成人亚洲高清一区| 国产午夜理论不卡在线观看| 国产精欧美一区二区三区 | 伊人精品成人久久综合97 | 一二三四在线观看免费视频| 麻豆av字幕无码中文| 国产亚洲精品久久久闺蜜| 西西4444www大胆无码| 肉大捧一进一出免费视频| 久久99精品久久久久久清纯| 亚洲裸男自慰gv网站| 精品久久久久久中文字幕| av无码电影一区二区三区| 国产乱码一区二区三区爽爽爽 | 欧美变态口味重另类在线视频| 亚洲熟妇国产熟妇肥婆| 久久久欧美精品激情| 玩弄放荡人妻少妇系列| 少妇系列之白嫩人妻| 欧美亚洲偷图色综合| 伊人狼人大焦香久久网| 草草久久久无码国产专区| 国产特级毛片aaaaaa| 人妻无码少妇一区二区| 黑人玩弄人妻中文在线|