在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FIS1 Antibody

  • 中文名稱:
    FIS1兔多克隆抗體
  • 貨號:
    CSB-PA008684GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    2010003O14Rik antibody; CGI 135 antibody; CGI135 antibody; FIS 1 antibody; FIS1 antibody; Fis1 homolog antibody; FIS1; S. cerevisiae; homolog of antibody; FIS1_HUMAN antibody; Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) antibody; Fission 1 (mitochondrial outer membrane) homolog (yeast) antibody; Fission 1 (mitochondrial outer membrane) homolog antibody; Fission 1 homolog antibody; H NH0132A01.6 antibody; hFis 1 antibody; hFis1 antibody; Mitochondrial fission 1 protein antibody; mitochondrial fission molecule antibody; Tetratricopeptide repeat domain 11 antibody; Tetratricopeptide repeat protein 11 antibody; TPR repeat protein 11 antibody; TTC 11 antibody; TTC11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FIS1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
  • 基因功能參考文獻:
    1. Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function. PMID: 27497958
    2. Results show that Fis1 is significantly overexpressed in malignant oncocytomas. PMID: 25822260
    3. Study revealed that a novel mitochondrial fission pathway composed of miR-483-5p and FIS1 regulates cisplatin sensitivity. PMID: 25843291
    4. Overexpression of FoxM1 and Plk1 in Fis1-depleted cells restores mitotic entry. PMID: 23907611
    5. Fis1 expression is significantly increased in spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis. PMID: 23713734
    6. Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. PMID: 23077178
    7. PEX11 proteins attract both Mff and human Fis1 (hFis1) to their site of action. PMID: 22595523
    8. Fis1 and dynamin-related protein (Drp)1 levels are remarkably increased in peripheral blood lymphocytes of Alzheimer's disease patients. PMID: 22340708
    9. Fis1 activity depends on its ability to interconvert between monomer and dimer species PMID: 22789569
    10. The mitochondrial fission protein Fission 1 homologue (Fis1) conveys an apoptosis signal from the mitochondria to the ER by interacting with Bap31 at the ER and facilitating its cleavage into the pro-apoptotic p20Bap31. PMID: 21183955
    11. we observed interactions between Drp1 and Fis1 in mitochondrial fragmentation induced by increasing mitochondrial calcium PMID: 20428767
    12. hFis1 can bind to multiple amino acid sequences selectively, and the tetratricopeptide repeat constitutes the main binding region of hFis1. PMID: 19864424
    13. hFis1 is part of the mammalian fission machinery and regulation of the fission processes might be involved in apoptotic mechanisms PMID: 12783892
    14. regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1 PMID: 12861026
    15. Cytosolic domain of fis1 adopts a tetratricopeptide repeat domain fold. PMID: 14705031
    16. the level of Fis1 at the mitochondrial surface influences mitochondrial fission events and hence overall mitochondrial morphology within the cell PMID: 14996942
    17. hFis1 induces mitochondrial fragmentation and perinuclear clustering in a state of calcium homeostasis PMID: 15024001
    18. Fis1 together with dynamin-related protein (Drp1) antogonizes Bcl-2. PMID: 16010987
    19. These findings provide the first evidence for a role of Fis1 in peroxisomal fission and suggest that the fission machinery of mitochondria and peroxisomes shares common components. PMID: 16107562
    20. TPR region of hFis1 participates in the interaction with DLP1 or DLP1-containing complex and that the first helix (alpha1) of hFis1 is required for mitochondrial fission presumably by regulating DLP1-hFis1 interaction. PMID: 16118244
    21. Direct induction of mitochondrial elongation by blocking mitochondrial fission process with Fis1-DeltaTM or Drp1-K38A was sufficient to develop senescent phenotypes with increased Reactive oxygen species production. PMID: 16883569
    22. hFis1 is a bifunctional protein that independently regulates mitochondrial fragmentation and endoplasmic reticulum-mediated apoptosis. PMID: 16914522
    23. Fis1 plays important roles in peroxisome division and maintenance of peroxisome morphology in mammalian cells, possibly in a concerted manner with Pex11pbeta and DLP1. PMID: 17408615
    24. hFis1 and OPA1 modulate cellular senescence PMID: 17545159
    25. the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted PMID: 17884824
    26. Changes correlate with mitochondrial dysfunction rather than with fragmentation, as substantiated by Fis1 mutants with different effects on organelle shape and function PMID: 18515060
    27. targeting of hFis1 to peroxisomes and mitochondria are independent events and support a direct, Pex19p-dependent targeting of peroxisomal tail-anchored proteins. PMID: 18782765
    28. Fis1 and Mfn1 activities influence mitochondrial signal generation thereby insulin exocytosis. PMID: 18832378
    29. oligomerization of hFis1 in the mitochondrial outer membrane plays a role in mitochondrial fission, potentially through participating in fission factor recruitment. PMID: 18845145

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
  • 蛋白家族:
    FIS1 family
  • 數據庫鏈接:

    HGNC: 21689

    OMIM: 609003

    KEGG: hsa:51024

    STRING: 9606.ENSP00000223136

    UniGene: Hs.423968



主站蜘蛛池模板: 亚洲精品久久久久久一区二区| 野外亲子乱子伦视频丶| 成年女人免费碰碰视频| 欧美老肥妇做爰bbww| 老熟妇乱子交视频一区| 国产草莓视频无码a在线观看 | 国产色婷婷五月精品综合在线| 国产午夜精品一区二区三区极品| 久久www成人影院| 国产ww久久久久久久久久| 亚洲妓女综合网99| 色欲久久人妻内射| 国产精品区一区二区三在线播放| 亚洲熟伦熟女新五十路熟妇| 无码日韩人妻精品久久| 精品aⅴ一区二区三区| 亚洲国产码专区| 中文字幕无码免费久久| 日本人妻人人人澡人人爽| 国产日韩未满十八禁止观看| 好男人在线社区www在线影院| 国产午夜亚洲精品不卡在线观看| 亚洲欧美日韩成人综合网| 国产69精品久久久久孕妇| 真人无码作爱免费视频| 欧美人与动牲交zooz乌克兰| 国产午夜片无码区在线观看爱情网| 婷婷丁香五月亚洲中文字幕| 国产成人一区二区三区在线| 久久九九精品99国产精品| 老汉老妇姓交视频| 蜜臀av在线观看| 色欲欲www成人网站| 欧美精品黑人粗大| 亚洲国产a∨无码中文777| 精品一区二区不卡无码av| 日韩精品无码免费专区午夜不卡| 国产女人抽搐喷浆视频| 中文字幕日本六区小电影| 精品国产经典三级在线看| 人澡人人澡人人澡欧美|