在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FIS1 Antibody

FIS1 Antibody

  • 中文名稱：
    FIS1兔多克隆抗體
  • 貨號：
    CSB-PA008684LA01HU
  • 規格：
    ￥3,900
  • 圖片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate(20μg), Hela whole cell lysate(20μg), HepG2 whole cell lysate(20μg), JK whole cell lysate(20μg), MCF7 whole cell lysate(20μg), K562 whole cell lysate(20μg),SH-SY5Y whole cell lysate(20μg),
      All lanes: FIS1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size:17 kDa
      Observed band size:17 kDa
      Exposure time: 180s
    • Western Blot
      Positive WB detected in: Mouse Heart tissue lysate(20μg),Mouse Brain tissue lysate(20μg)
      All lanes: FIS1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 17 kDa
      Observed band size: 17 kDa
      Exposure time: 60s
  • 其他：

產品詳情

  • 產品描述：

    The FIS1 antibody is a premium polyclonal antibody suitable for the detection of the human FIS1 protein. It is available as the unconjugated IgG isoform. This FIS1 antibody is raised in the rabbit against a partial recombinant protein corresponding to amino acids 1-122 of human FIS1. This FIS1 antibody is purified by protein G affinity chromatography with a purity of up to 95%. And it is recommended for use in ELISA, IHC, and IF applications.

    Its target protein FIS1 mainly functions to regulate mitochondrial fission, morphology, and dynamics. It is involved in the recruitment of DRP1 to the mitochondrial outer membrane and plays a crucial role in mitochondrial quality control and energy metabolism. Dysregulation of FIS1 can contribute to mitochondrial dysfunction and various diseases.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FIS1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    2010003O14Rik antibody; CGI 135 antibody; CGI135 antibody; FIS 1 antibody; FIS1 antibody; Fis1 homolog antibody; FIS1; S. cerevisiae; homolog of antibody; FIS1_HUMAN antibody; Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) antibody; Fission 1 (mitochondrial outer membrane) homolog (yeast) antibody; Fission 1 (mitochondrial outer membrane) homolog antibody; Fission 1 homolog antibody; H NH0132A01.6 antibody; hFis 1 antibody; hFis1 antibody; Mitochondrial fission 1 protein antibody; mitochondrial fission molecule antibody; Tetratricopeptide repeat domain 11 antibody; Tetratricopeptide repeat protein 11 antibody; TPR repeat protein 11 antibody; TTC 11 antibody; TTC11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Mitochondrial fission 1 protein (1-122AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen?affinity?purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.02% sodium azide
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
  • 基因功能參考文獻：
    1. Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function. PMID: 27497958
    2. Results show that Fis1 is significantly overexpressed in malignant oncocytomas. PMID: 25822260
    3. Study revealed that a novel mitochondrial fission pathway composed of miR-483-5p and FIS1 regulates cisplatin sensitivity. PMID: 25843291
    4. Overexpression of FoxM1 and Plk1 in Fis1-depleted cells restores mitotic entry. PMID: 23907611
    5. Fis1 expression is significantly increased in spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis. PMID: 23713734
    6. Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. PMID: 23077178
    7. PEX11 proteins attract both Mff and human Fis1 (hFis1) to their site of action. PMID: 22595523
    8. Fis1 and dynamin-related protein (Drp)1 levels are remarkably increased in peripheral blood lymphocytes of Alzheimer's disease patients. PMID: 22340708
    9. Fis1 activity depends on its ability to interconvert between monomer and dimer species PMID: 22789569
    10. The mitochondrial fission protein Fission 1 homologue (Fis1) conveys an apoptosis signal from the mitochondria to the ER by interacting with Bap31 at the ER and facilitating its cleavage into the pro-apoptotic p20Bap31. PMID: 21183955
    11. we observed interactions between Drp1 and Fis1 in mitochondrial fragmentation induced by increasing mitochondrial calcium PMID: 20428767
    12. hFis1 can bind to multiple amino acid sequences selectively, and the tetratricopeptide repeat constitutes the main binding region of hFis1. PMID: 19864424
    13. hFis1 is part of the mammalian fission machinery and regulation of the fission processes might be involved in apoptotic mechanisms PMID: 12783892
    14. regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1 PMID: 12861026
    15. Cytosolic domain of fis1 adopts a tetratricopeptide repeat domain fold. PMID: 14705031
    16. the level of Fis1 at the mitochondrial surface influences mitochondrial fission events and hence overall mitochondrial morphology within the cell PMID: 14996942
    17. hFis1 induces mitochondrial fragmentation and perinuclear clustering in a state of calcium homeostasis PMID: 15024001
    18. Fis1 together with dynamin-related protein (Drp1) antogonizes Bcl-2. PMID: 16010987
    19. These findings provide the first evidence for a role of Fis1 in peroxisomal fission and suggest that the fission machinery of mitochondria and peroxisomes shares common components. PMID: 16107562
    20. TPR region of hFis1 participates in the interaction with DLP1 or DLP1-containing complex and that the first helix (alpha1) of hFis1 is required for mitochondrial fission presumably by regulating DLP1-hFis1 interaction. PMID: 16118244
    21. Direct induction of mitochondrial elongation by blocking mitochondrial fission process with Fis1-DeltaTM or Drp1-K38A was sufficient to develop senescent phenotypes with increased Reactive oxygen species production. PMID: 16883569
    22. hFis1 is a bifunctional protein that independently regulates mitochondrial fragmentation and endoplasmic reticulum-mediated apoptosis. PMID: 16914522
    23. Fis1 plays important roles in peroxisome division and maintenance of peroxisome morphology in mammalian cells, possibly in a concerted manner with Pex11pbeta and DLP1. PMID: 17408615
    24. hFis1 and OPA1 modulate cellular senescence PMID: 17545159
    25. the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted PMID: 17884824
    26. Changes correlate with mitochondrial dysfunction rather than with fragmentation, as substantiated by Fis1 mutants with different effects on organelle shape and function PMID: 18515060
    27. targeting of hFis1 to peroxisomes and mitochondria are independent events and support a direct, Pex19p-dependent targeting of peroxisomal tail-anchored proteins. PMID: 18782765
    28. Fis1 and Mfn1 activities influence mitochondrial signal generation thereby insulin exocytosis. PMID: 18832378
    29. oligomerization of hFis1 in the mitochondrial outer membrane plays a role in mitochondrial fission, potentially through participating in fission factor recruitment. PMID: 18845145

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
  • 蛋白家族：
    FIS1 family
  • 數據庫鏈接：

    HGNC: 21689

    OMIM: 609003

    KEGG: hsa:51024

    STRING: 9606.ENSP00000223136

    UniGene: Hs.423968



主站蜘蛛池模板： 婷婷伊人五月尤物| 69成人免费视频无码专区| 爆乳护士一区二区三区在线播放 | 国产一卡三卡四卡无卡精品 | 亚洲综合色在线视频www| 成人综合网亚洲伊人| 欧美中日韩免费观看网站| 欧美日本国产va高清cabal| 国产又爽又黄又不遮挡视频| 天堂在线www资源在线| 4hu亚洲人成人无码网www电影首页| 开心久久婷婷综合中文字幕| 丰满少妇作爱视频免费观看| 人人爽天天碰狠狠添| 亚洲国产精品久久久久婷婷软件| 一二三四免费观看在线视频中文版| 久久精品九九热无码免贵| 久久精品99国产国产精| 亚洲人成无码网www电影麻豆| 天堂岛国av无码免费无禁网站| 日日噜狠狠噜天天噜av| 最新亚洲春色av无码专区| av无码国产在线观看岛国| 国产欧美日韩亚洲18禁在线| 亚洲国产精品久久久久久无码| 熟女丰满老熟女熟妇| 日本少妇xxx做受| 丰满少妇被猛烈进入试看| 国产乱人伦av在线无码| 免费观看女人高潮视频软件| 亚洲精品久久久久午夜aⅴ| 国产成人精品久久| 无码人妻久久一区二区三区不卡 | 欧美性插b在线视频网站| 久久综合97丁香色香蕉| 亚洲精品国产av现线| 无套内内射视频网站| 国产精品成人免费999| 国产亚洲日韩一区二区三区| 性欧美大战久久久久久久久 | 成人亚洲精品久久99狠狠|