在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGR Antibody

  • 中文名稱:
    FGR兔多克隆抗體
  • 貨號:
    CSB-PA824952
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells and COLO205 cells, using FGR antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FGR Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human FGR.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production.
  • 基因功能參考文獻:
    1. Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival. PMID: 28585144
    2. the Src tyrosine kinase Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance. PMID: 27324824
    3. we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule. PMID: 25972488
    4. Data indicate that combined treatment using SFK (LYN, HCK, or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of acute myeloid leukemia (AML) stem cells. PMID: 23896410
    5. Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target PMID: 21300758
    6. Substitution of two relevant serines with glutamic acid residues in urokinase prevents urokinase activation of p55fgr needed for cell migration and adhesion. PMID: 11928806
    7. Recruitment of the coactivator, SRC2, is coupled to cooperative DNA binding by the progesterone receptor. PMID: 17845055

    顯示更多

    收起更多

  • 相關疾病:
    Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
  • 組織特異性:
    Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
  • 數據庫鏈接:

    HGNC: 3697

    OMIM: 164940

    KEGG: hsa:2268

    STRING: 9606.ENSP00000363115

    UniGene: Hs.1422



主站蜘蛛池模板: 女高中生自慰污污网站| 欧美丰腴丰满大屁股熟妇| 亚洲成a人片在线播放| 免费又黄又爽又猛的毛片| 国产成人精品aa毛片| 国产舌乚八伦偷品w中| 丰满护士巨好爽好大乳| 中文字幕无线观看不卡网站| 无码精品黑人一区二区三区| 亚洲日韩中文字幕一区 | 日本不卡不码高清视频| 不卡无码人妻一区二区三区| 人妻少妇精品一区二区三区| 国产精品ⅴ无码大片在线看| 国产精品一区波多野结衣| 波多野无码黑人在线播放| 一边吃奶一边做动态图| 97精品一区二区视频在线观看| 亚洲国产精品尤物yw在线| av边做边流奶水无码免费| 亚洲色丰满少妇高潮18p| 毛片免费全部无码播放| 蜜桃网站入口可看18禁| 成人午夜精品无码一区二区三区| 强开小婷嫩苞又嫩又紧视频| 久久精品国产99国产精品澳门| 内射人妻无套中出无码| 天堂а√中文在线| 黑人巨大精品欧美一区二区免费| 日韩中文字幕免费视频| 人妻中文字幕无码系列| 伊人精品成人久久综合97| 欧美疯狂做受xxxx高潮| 男女野外做爰全过程69影院| 亚洲亚洲人成综合丝袜图片| 极品美女扒开粉嫩小泬| 国产精品交换| 国语自产拍在线视频中文| 亚洲熟女av综合网五月| 久久国产精品99国产精| 人人狠狠综合久久88成人|