在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGR Antibody, FITC conjugated

  • 中文名稱:
    FGR兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA008655LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FGR Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    c fgr antibody; c fgr protooncogene antibody; c src 2 proto oncogene antibody; c src2 antibody; Fgr antibody; FGR_HUMAN antibody; FLJ43153 antibody; Gardner Rasheed feline sarcoma viral (v fgr) antibody; Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody; MGC75096 antibody; p55 c fgr protein antibody; P55 FGR antibody; P55-FGR antibody; p55c fgr antibody; p58-Fgr antibody; p58c fgr antibody; p58c-Fgr antibody; Proto oncogene c Fgr antibody; Proto oncogene tyrosine protein kinase FGR antibody; Proto-oncogene c-Fgr antibody; SRC 2 antibody; SRC2 antibody; Tyrosine protein kinase Fgr antibody; Tyrosine-protein kinase Fgr antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tyrosine-protein kinase Fgr protein (11-72AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production.
  • 基因功能參考文獻:
    1. Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival. PMID: 28585144
    2. the Src tyrosine kinase Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance. PMID: 27324824
    3. we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule. PMID: 25972488
    4. Data indicate that combined treatment using SFK (LYN, HCK, or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of acute myeloid leukemia (AML) stem cells. PMID: 23896410
    5. Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target PMID: 21300758
    6. Substitution of two relevant serines with glutamic acid residues in urokinase prevents urokinase activation of p55fgr needed for cell migration and adhesion. PMID: 11928806
    7. Recruitment of the coactivator, SRC2, is coupled to cooperative DNA binding by the progesterone receptor. PMID: 17845055

    顯示更多

    收起更多

  • 相關疾病:
    Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
  • 組織特異性:
    Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
  • 數據庫鏈接:

    HGNC: 3697

    OMIM: 164940

    KEGG: hsa:2268

    STRING: 9606.ENSP00000363115

    UniGene: Hs.1422



主站蜘蛛池模板: 欧美性受xxxx黑人xyx性爽| 免费人成小说在线观看网站| 亲嘴扒胸摸屁股激烈网站| 免费三级现频在线观看免费| 大香线蕉伊人精品超碰| 午夜爽爽爽男女免费观看麻豆国产| 日韩av高潮喷水在线观看| 国产精品毛多多水多| 最新精品香蕉在线| 国产亚洲日韩在线播放更多| 一本一本久久a久久综合精品| 欧美丰满熟妇xxxx性ppx人| 狠狠噜天天噜日日噜| 国产午夜精品理论片| 久久婷婷六月综合色液啪| 亚洲国产码专区| 国产午夜亚洲精品不卡下载| 久久se精品一区精品二区| 成人无码在线视频网站| 久久久久国产精品人妻aⅴ果冻| 99精品国产成人一区二区| 小泽玛莉亚一区二区视频在线| 国产真实野战在线视频| 色偷偷偷久久伊人大杳蕉| 亚洲人成网网址在线看| 国产一区二区三区影院| 国产成人av国语在线观看| 国产午夜永久福利视频在线观看| 国产香蕉尹人视频在线| 插我舔内射18免费视频| 中文字幕奈奈美被公侵犯| 久久精晶国产99久久6| 国产高清av首播原创麻豆| 久久综合九色综合欧美婷婷| 国产麻豆精品福利在线观看| 国产超碰人人做人人爱ⅴa| 色综合天天综合网中文| 国产偷国产偷亚洲清高孕妇| 欧美饥渴熟妇高潮喷水水| 骚片av蜜桃精品一区| 久久久久久一区国产精品|