在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGD5 Antibody

  • 中文名稱:
    FGD5兔多克隆抗體
  • 貨號:
    CSB-PA008613GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FGD5
  • 別名:
    FGD5 antibody; ZFYVE23FYVE antibody; RhoGEF and PH domain-containing protein 5 antibody; Zinc finger FYVE domain-containing protein 23 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FGD5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
  • 基因功能參考文獻:
    1. We found that depletion of FGD5 in microvascular cells inhibited their migration towards a stable VEGFA gradient. Furthermore, depletion of FGD5 resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 sustains VEGFA signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation. PMID: 28927665
    2. FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (phosphoinositide-3) kinase/mTORC2-dependent cytoskeletal remodeling in endothelial cells. PMID: 29051140
    3. FGD5 is a new prognostic marker in breast cancer, and increased copy number is associated with higher tumour proliferation and poorer long-term prognosis. PMID: 28124285
    4. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis. PMID: 26748901
    5. FGD5 regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling. PMID: 22922960
    6. FGD5 inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. PMID: 22661514
    7. Suggest that FGD5 regulates proangiogenic action of VEGF in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation. PMID: 22328776

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
  • 組織特異性:
    Expressed in endothelial cells (at protein level).
  • 數據庫鏈接:

    HGNC: 19117

    OMIM: 614788

    KEGG: hsa:152273

    STRING: 9606.ENSP00000285046

    UniGene: Hs.412406



主站蜘蛛池模板: 亚洲日韩久久综合中文字幕| 鲁一鲁一鲁一鲁一曰综合网| 亚洲欧美综合成人五月天网站 | 亚洲国产精品国语在线| 国产aⅴ爽av久久久久久| h无码精品3d动漫在线观看 | 成年男人裸j照无遮挡无码| 亚洲熟妇av午夜无码不卡| 欧美伦费免费全部午夜最新| 农村老熟妇乱子伦视频| 国产精品天干天干综合网| 欧美国产日韩a在线观看| 成人午夜无码精品免费看| 国产高清在线精品二区| 未满小14洗澡无码视频网站 | 国产精品福利视频萌白酱| 成+人+网+站+免费观看| 97精品国产一区二区三区四区| 亚洲人妻av伦理| 成熟丰满熟妇高潮xxxxx视频| 亚洲成a人片77777国产| 无码三级中文字幕在线观看| 欧美日韩精品| 极品少妇hdxx麻豆hdxx| 国产成人免费无庶挡视频| 欧美丰满熟妇xxxx性ppx人| 国产精品久久久久久久免费看| 黑人大荫蒂高潮视频| 亚洲色成人网站永久| 久青草国产在视频在线观看| 性做久久久久久久| 蜜臀av色欲a片无码精品一区| 精品久久久久久777米琪桃花| 亚洲无线卡一卡二| 无码毛片视频一区二区本码 | 西西人体大胆瓣开下部毛茸茸| 国产又色又爽又黄的视频在线观看| 日本欧美一区二区三区乱码| 艳妇乳肉豪妇荡乳av无码福利| 性夜影院午夜看片| 精品国产午夜理论片不卡精品|