在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FGD5 Antibody

FGD5 Antibody

  • 中文名稱：
    FGD5兔多克隆抗體
  • 貨號：
    CSB-PA008613GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    FGD5
  • 別名：
    FGD5 antibody; ZFYVE23FYVE antibody; RhoGEF and PH domain-containing protein 5 antibody; Zinc finger FYVE domain-containing protein 23 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FGD5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
  • 基因功能參考文獻：
    1. We found that depletion of FGD5 in microvascular cells inhibited their migration towards a stable VEGFA gradient. Furthermore, depletion of FGD5 resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 sustains VEGFA signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation. PMID: 28927665
    2. FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (phosphoinositide-3) kinase/mTORC2-dependent cytoskeletal remodeling in endothelial cells. PMID: 29051140
    3. FGD5 is a new prognostic marker in breast cancer, and increased copy number is associated with higher tumour proliferation and poorer long-term prognosis. PMID: 28124285
    4. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis. PMID: 26748901
    5. FGD5 regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling. PMID: 22922960
    6. FGD5 inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. PMID: 22661514
    7. Suggest that FGD5 regulates proangiogenic action of VEGF in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation. PMID: 22328776

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
  • 組織特異性：
    Expressed in endothelial cells (at protein level).
  • 數據庫鏈接：

    HGNC: 19117

    OMIM: 614788

    KEGG: hsa:152273

    STRING: 9606.ENSP00000285046

    UniGene: Hs.412406



主站蜘蛛池模板： 国产精品黄页免费高清在线观看| 51精品国产人成在线观看| 国产农村妇女精品一二区| 日韩高清亚洲日韩精品一区| 中文字幕久久精品一区二区三区 | 日产精品久久久久久久性色| 国产精品免费一区二区三区四区| 欧美成人综合久久精品| 欧美国产日韩a欧美在线观看| 国产亚洲精品久久久久的角色| 国产97在线 | 亚洲| 亚洲精品尤物av在线观看不卡| 久久久久国色av∨免费看 | 东京热人妻丝袜无码av一二三区观 | 欧美黑人欧美精品刺激| 色欲色香天天天综合网站| 欧美精品人人做人人爱视频| 亚洲熟妇无码av在线播放| 国产成人+亚洲欧洲+综合| 欧产日产国产精品| 久久久精品人妻一区二区三区四| 亚洲欧美色一区二区三区| 日韩在线一区二区不卡视频| 亚洲色成人一区二区三区| 日韩少妇内射免费播放18禁裸乳 | 婷婷色综合视频在线观看| 大地资源在线观看官网第三页| 国产一区二区| 亚洲a成人无码网站在线| 四虎成人国产精品永久在线 | 国产肥白大熟妇bbbb视频| 亚洲 欧美 成人 自拍 高清| 撕开奶罩揉吃奶高潮av在线观看| 国产av无码国产av毛片| 高大丰满熟妇丰满的大白屁股| 国产成人亚洲精品无码电影| 小草国产精品情侣| 久久国产一区二区三区| 成年女人免费v片| 骚虎成人免费99xx| 搡女人真爽免费视频大全|