在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGD5 Antibody

  • 中文名稱:
    FGD5兔多克隆抗體
  • 貨號:
    CSB-PA008613GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FGD5
  • 別名:
    FGD5 antibody; ZFYVE23FYVE antibody; RhoGEF and PH domain-containing protein 5 antibody; Zinc finger FYVE domain-containing protein 23 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FGD5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
  • 基因功能參考文獻:
    1. We found that depletion of FGD5 in microvascular cells inhibited their migration towards a stable VEGFA gradient. Furthermore, depletion of FGD5 resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 sustains VEGFA signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation. PMID: 28927665
    2. FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (phosphoinositide-3) kinase/mTORC2-dependent cytoskeletal remodeling in endothelial cells. PMID: 29051140
    3. FGD5 is a new prognostic marker in breast cancer, and increased copy number is associated with higher tumour proliferation and poorer long-term prognosis. PMID: 28124285
    4. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis. PMID: 26748901
    5. FGD5 regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling. PMID: 22922960
    6. FGD5 inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. PMID: 22661514
    7. Suggest that FGD5 regulates proangiogenic action of VEGF in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation. PMID: 22328776

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
  • 組織特異性:
    Expressed in endothelial cells (at protein level).
  • 數據庫鏈接:

    HGNC: 19117

    OMIM: 614788

    KEGG: hsa:152273

    STRING: 9606.ENSP00000285046

    UniGene: Hs.412406



主站蜘蛛池模板: 日本特黄aaaaaa片在线观看| 一二三四免费观看在线视频中文版| 国产精品无码av天天爽| 久久精品国产欧美日韩99热 | 亚洲午夜福利精品无码不卡| av天堂午夜精品一区| 又色又爽又黄的视频软件app| 国产农村乱对白刺激视频| 在线亚洲精品国产一区麻豆| 久久免费视频精品在线| 国产av一二三无码影片| 影音先锋无码aⅴ男人资源站| 欧美gv在线观看| 久久精品香蕉绿巨人登场| 多人伦交性欧美| 免费看成人aa片无码视频吃奶| 国产亚洲精品久久777777| 中文字幕人妻被公上司喝醉在线| 久久无码超清激情av| 最近最新中文字幕高清免费| 丰满人妻中伦妇伦精品app| 日本少妇裸体做爰高潮片 | 国产真实乱对白精彩久久| 国产特黄级aaaaa片免| 浮妇高潮喷白浆视频| 永久免费毛片在线播放| 一边捏奶一边高潮视频| 久久亚洲精品成人av| 国产喷水福利在线视频| 欧洲熟妇色xxxxx欧美| 久久经精品久久精品免费观看| 久久久久99精品成人片直播| 狼色精品人妻在线视频免费 | 免费天堂无码人妻成人av电影 | 蜜臀av网站在线| 亚洲图片综合图区20p| 麻麻张开腿让我爽了一夜| 国内少妇偷人精品免费| 色六月婷婷亚洲婷婷六月| 小罗莉极品一线天在线| 中国国语毛片免费观看视频|