在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FGD5 Antibody

FGD5 Antibody

  • 中文名稱：
    FGD5兔多克隆抗體
  • 貨號：
    CSB-PA008613GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    FGD5
  • 別名：
    FGD5 antibody; ZFYVE23FYVE antibody; RhoGEF and PH domain-containing protein 5 antibody; Zinc finger FYVE domain-containing protein 23 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FGD5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
  • 基因功能參考文獻：
    1. We found that depletion of FGD5 in microvascular cells inhibited their migration towards a stable VEGFA gradient. Furthermore, depletion of FGD5 resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 sustains VEGFA signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation. PMID: 28927665
    2. FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (phosphoinositide-3) kinase/mTORC2-dependent cytoskeletal remodeling in endothelial cells. PMID: 29051140
    3. FGD5 is a new prognostic marker in breast cancer, and increased copy number is associated with higher tumour proliferation and poorer long-term prognosis. PMID: 28124285
    4. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis. PMID: 26748901
    5. FGD5 regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling. PMID: 22922960
    6. FGD5 inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. PMID: 22661514
    7. Suggest that FGD5 regulates proangiogenic action of VEGF in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation. PMID: 22328776

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
  • 組織特異性：
    Expressed in endothelial cells (at protein level).
  • 數據庫鏈接：

    HGNC: 19117

    OMIM: 614788

    KEGG: hsa:152273

    STRING: 9606.ENSP00000285046

    UniGene: Hs.412406



主站蜘蛛池模板： 精品国产一区二区三区四区在线看| 潮喷失禁大喷水av无码| 无码专区丰满人妻斩六十路| 国产成人无码精品亚洲| 久久99国产综合精品| 无遮挡国产高潮视频免费观看 | 国内精品久久久久影院亚瑟| 天天摸夜夜添夜夜无码| 中国大陆高清aⅴ毛片| 国产乱子伦农村叉叉叉| 日韩综合亚洲色在线影院| 人人爽人人添人人超| 牲交欧美兽交欧美| 男女性爽大片视频| 亚洲欧美日韩综合久久久| 久久九九有精品国产23百花影院| 久久精品中文字幕有码| 国产精品久久久久aaaa| 国产成人精品a视频| 国产午夜精品一区二区三区极品| 亚洲精品第一国产综合国服瑶 | 精品产区wnw2544| 成人无码a片一区二区三区免 | 国产在线观看无码免费视频| 亚洲国产av高清无码| 亚洲国产精品成人精品无码区在线| 女人扒下裤让男人桶到爽| 久久精品手机观看| 久久久久成人网站| 国产成人无码精品久久久性色| 在线观看高清黄网站观看| 性高湖久久久久久久久| 国产成人精品综合在线观看 | 国产亚洲tv在线观看| 人妻无码精品久久亚瑟影视| 乱人伦人妻中文字幕无码久久网| 久久精品国产99国产精偷| 四虎影在永久在线观看| 婷婷综合缴情亚洲狠狠小说| 欧美成人看片黄a免费看| 亚洲精品久久久久高潮|