在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FGD5 Antibody, Biotin conjugated

FGD5 Antibody, Biotin conjugated

  • 中文名稱：
    FGD5兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA757939LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FGD5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FGD5
  • 別名：
    FGD5 antibody; ZFYVE23FYVE antibody; RhoGEF and PH domain-containing protein 5 antibody; Zinc finger FYVE domain-containing protein 23 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 protein (269-539AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
  • 基因功能參考文獻：
    1. We found that depletion of FGD5 in microvascular cells inhibited their migration towards a stable VEGFA gradient. Furthermore, depletion of FGD5 resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 sustains VEGFA signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation. PMID: 28927665
    2. FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (phosphoinositide-3) kinase/mTORC2-dependent cytoskeletal remodeling in endothelial cells. PMID: 29051140
    3. FGD5 is a new prognostic marker in breast cancer, and increased copy number is associated with higher tumour proliferation and poorer long-term prognosis. PMID: 28124285
    4. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis. PMID: 26748901
    5. FGD5 regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling. PMID: 22922960
    6. FGD5 inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. PMID: 22661514
    7. Suggest that FGD5 regulates proangiogenic action of VEGF in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation. PMID: 22328776

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
  • 組織特異性：
    Expressed in endothelial cells (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19117

    OMIM: 614788

    KEGG: hsa:152273

    STRING: 9606.ENSP00000285046

    UniGene: Hs.412406



主站蜘蛛池模板： 亚洲欧美中文字幕日韩一区二区| 国语精品福利自产拍在线观看| 3d动漫精品啪啪一区二区中| 国内精品久久久久久久电影视| 亚洲日韩av无码| 激情综合五月| 日日做夜狠狠爱欧美黑人| 国产性夜夜春夜夜爽免费下载| 国产 亚洲 制服 无码 中文| 天天爽天天爽天天爽| 色九月亚洲综合网| 亚洲国产美女久久久久| 国产片av片永久免费观看| 一本加勒比hezyo无码人妻| 99精品偷自拍| 国产在线观看黄av免费| 久久国产人妻一区二区免费| 草草地址线路①屁屁影院成人| 久久777国产线看观看精品| 无码h黄肉动漫在线观看| 亚洲乱码日产精品bd在观看| 波多野结衣av无码久久一区| 婷婷五月综合激情中文字幕| 日产精品一卡2卡三卡4乱码| 无码人妻丰满熟妇区96| 欧美成人家庭影院| 男女做爽爽爽视频免费软件| 亚洲最大无码中文字幕网站| 狠狠躁夜夜躁人人躁婷婷视频| 国产精品久久久久久久久人妻| 香蕉久久av一区二区三区app| 亚洲欲色欲香天天综合网| 国产精品99精品无码视亚| 欧美黑人与白人精品a片| 成人免费无码大片a毛片户外| 熟妇人妻系列av无码一区二区| 亚洲色婷婷六月亚洲婷婷6月| 日本一区二区三区免费播放视频站| www婷婷av久久久影片| 欧美巨鞭大战丰满少妇| 欧洲 亚洲 国产图片综合|