在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FEZ1 Antibody, HRP conjugated

  • 中文名稱:
    FEZ1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA03389B0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FEZ1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FEZ1
  • 別名:
    FEZ1Fasciculation and elongation protein zeta-1 antibody; Zygin I antibody; Zygin-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Fasciculation and elongation protein zeta-1 protein (12-200AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.
  • 基因功能參考文獻:
    1. FEZ1 promotes HIV-1 infection in non-neuronal cells via direct binding to the capsid and kinesin-1 to move the virus into the cell nucleus. PMID: 25818806
    2. SCOC forms a stable homogeneous complex with the coiled coil domain of FEZ1. SCOC dimerization and the SCOC surface residue R117 are important for this interaction. PMID: 24098481
    3. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. PMID: 24116125
    4. Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to NDEL1 and phosphodiesterase (PDE)4B proteins but fully interact with FEZ1 and GSK3beta. PMID: 22832604
    5. FEZ1 operates as a kinesin adaptor for the transport of Stx, with cargo loading and unloading being regulated by protein kinases. PMID: 22451907
    6. The data of this study suggested that FEZ1 may play important roles in human astrocytes, and that mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes. PMID: 22017218
    7. Genetic association analysis of two independent cohorts of schizophrenia patients and healthy controls reveals an epistatic interaction between FEZ1 and disrupted in schizophrenia (DISC)1. PMID: 22099459
    8. Demonstrated the formation of an intermolecular disulfide bond through FEZ1 Cys-133, which appears to be essential for dimerization. PMID: 20812761
    9. Studies indicate that suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. PMID: 20730382
    10. Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro. PMID: 19924516
    11. interacts with NBR1 protein PMID: 11856312
    12. FEZ1 is an interacting partner of DISC1. The interaction of DISC1 and FEZ1 is associated with direct FEZ1 binding to F-actin. PMID: 12874605
    13. E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation PMID: 15466860
    14. A modest association between FEZ1 and Schizophrenia was found. PMID: 15522253
    15. FEZ1 promotes neurite extension through its interaction with microtubules, and agnoprotein facilitates JCV propagation by inducing the dissociation of FEZ1 from microtubules PMID: 15843383
    16. We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia. PMID: 17374448
    17. Data suggest that FEZ1 has an important centrosomal function and supply new mechanistic insights to the formation of flower-like nuclei, which are a phenotypical hallmark of human leukemia cells. PMID: 18439996
    18. Data show that the expression of FEZ1,GAD1, and RGS4 are high correlated with one another in the prefrontal cortex of postmortem brain samples. PMID: 18470533
    19. Human FEZ1 has characteristics of a natively unfolded protein and dimerizes in solution. PMID: 18615714
    20. There was no strong evidence for association with FEZ1 in schizophrenia. PMID: 19632097
    21. FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1 PMID: 19667186

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.
  • 蛋白家族:
    Zygin family
  • 組織特異性:
    Mainly expressed in brain.
  • 數據庫鏈接:

    HGNC: 3659

    OMIM: 604825

    KEGG: hsa:9638

    STRING: 9606.ENSP00000278919

    UniGene: Hs.224008



主站蜘蛛池模板: 一本一道久久综合狠狠老| 欧美深性狂猛ⅹxxx深喉| 全部孕妇毛片| 日韩精品人妻无码久久影院| 亚洲中文字幕日产无码成人片| 免费人成在线视频无码| 国产老太睡小伙子视频| 国产男小鲜肉同志免费| 狠狠色噜噜狠狠狠7777奇米| 国产 麻豆 日韩 欧美 久久| 亚洲精品久久久无码av片软件| 国产孩cao大人xxxx| 欧美又黄又大又爽a片三年片| 人妻体内射精一区二区三四| 久久这里只有精品18| 国精产品一区二区三区| 国产亚洲精aa在线观看不卡| 日本三级欧美三级人妇视频| 久久99精品久久久久久9蜜桃| 性xxxx18免费观看视频| 国产av无码专区国产乱码 | 日韩欧美一中文字暮专区| 女同免费毛片在线播放| 精品亚洲aⅴ在线无码播放| 最近2019免费中文第一页| 97久久综合区小说区图片区| 色妞精品av一区二区三区| 东京热无码一区二区三区av| 亚洲成av人片在线观看无| 午夜成人理论福利片| 久久精品农村毛片| 国内精品自线在拍2020不卡| 亚洲熟女综合色一区二区三区| 国产精品久久午夜夜伦鲁鲁| 亚洲国产精品久久久久婷蜜芽| 色猫咪免费人成网站在线观看| 成人伊人青草久久综合网| 国产人妖xxxx做受视频| 亚洲国产成人av人片久久| 潮喷失禁大喷水av无码| 中文字幕无码第1页|