在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FEZ1 Antibody, FITC conjugated

  • 中文名稱:
    FEZ1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA03389C0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FEZ1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FEZ1
  • 別名:
    FEZ1Fasciculation and elongation protein zeta-1 antibody; Zygin I antibody; Zygin-1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Fasciculation and elongation protein zeta-1 protein (12-200AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.
  • 基因功能參考文獻(xiàn):
    1. FEZ1 promotes HIV-1 infection in non-neuronal cells via direct binding to the capsid and kinesin-1 to move the virus into the cell nucleus. PMID: 25818806
    2. SCOC forms a stable homogeneous complex with the coiled coil domain of FEZ1. SCOC dimerization and the SCOC surface residue R117 are important for this interaction. PMID: 24098481
    3. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. PMID: 24116125
    4. Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to NDEL1 and phosphodiesterase (PDE)4B proteins but fully interact with FEZ1 and GSK3beta. PMID: 22832604
    5. FEZ1 operates as a kinesin adaptor for the transport of Stx, with cargo loading and unloading being regulated by protein kinases. PMID: 22451907
    6. The data of this study suggested that FEZ1 may play important roles in human astrocytes, and that mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes. PMID: 22017218
    7. Genetic association analysis of two independent cohorts of schizophrenia patients and healthy controls reveals an epistatic interaction between FEZ1 and disrupted in schizophrenia (DISC)1. PMID: 22099459
    8. Demonstrated the formation of an intermolecular disulfide bond through FEZ1 Cys-133, which appears to be essential for dimerization. PMID: 20812761
    9. Studies indicate that suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. PMID: 20730382
    10. Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro. PMID: 19924516
    11. interacts with NBR1 protein PMID: 11856312
    12. FEZ1 is an interacting partner of DISC1. The interaction of DISC1 and FEZ1 is associated with direct FEZ1 binding to F-actin. PMID: 12874605
    13. E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation PMID: 15466860
    14. A modest association between FEZ1 and Schizophrenia was found. PMID: 15522253
    15. FEZ1 promotes neurite extension through its interaction with microtubules, and agnoprotein facilitates JCV propagation by inducing the dissociation of FEZ1 from microtubules PMID: 15843383
    16. We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia. PMID: 17374448
    17. Data suggest that FEZ1 has an important centrosomal function and supply new mechanistic insights to the formation of flower-like nuclei, which are a phenotypical hallmark of human leukemia cells. PMID: 18439996
    18. Data show that the expression of FEZ1,GAD1, and RGS4 are high correlated with one another in the prefrontal cortex of postmortem brain samples. PMID: 18470533
    19. Human FEZ1 has characteristics of a natively unfolded protein and dimerizes in solution. PMID: 18615714
    20. There was no strong evidence for association with FEZ1 in schizophrenia. PMID: 19632097
    21. FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1 PMID: 19667186

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.
  • 蛋白家族:
    Zygin family
  • 組織特異性:
    Mainly expressed in brain.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3659

    OMIM: 604825

    KEGG: hsa:9638

    STRING: 9606.ENSP00000278919

    UniGene: Hs.224008



主站蜘蛛池模板: 日本中国内射bbxx| 青青青国产免a在线观看| 亚洲成a人片77777国产| 久久亚洲精品无码爱剪辑| 久久成人网站亚洲综合| 超清中文乱码一区| 东京热无码av一区二区| 午夜精品久久久久久久99热| 无套熟女av呻吟在线观看| 天天躁夜夜躁狠狠躁2021| 亚洲一线二线三线品牌精华液久久久| 一卡二卡3卡四卡网站精品| 蜜臀av在线播放一区二区三区| 亚洲国产精品久久久久爰色欲| 国产超薄肉色丝袜视频| 人人爽人人爽人人片a免费| 亚洲精品鲁一鲁一区二区三区| 丰满的少妇xxxxx青青青| 久久久中文久久久无码| 国产白嫩漂亮美女在线观看| 曰本一道本久久88不卡| 国产精品丝袜一区二区三区| 无码午夜成人1000部免费视频| 狠狠色老熟妇老熟女| 国产亚洲精aa在线观看| 国产熟妇乱xxxxx大屁股网| 人妻精油按摩bd高清中文字幕| 一本久久a久久免费精品不卡| 欧美精欧美乱码一二三四区| 夜夜高潮夜夜爽夜夜爱爱一区| 免费大片黄在线观看| 亚洲国产成人精品青青草原| 无码中文人妻在线一区| 色yeye香蕉凹凸视频在线观看| 国产三级在线观看播放视频| 性无码专区无码| 国产精品无码久久久久| 久久中文精品无码中文字幕| 亚洲精品久久久一区| 中文亚洲欧美日韩无线码| 日韩精品毛片无码一区到三区|