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Your Good Partner in Biology Research

FEN1 Antibody

Rare Species
  • 中文名稱:
    FEN1兔多克隆抗體
  • 貨號(hào):
    CSB-PA008585XA01DOA
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: FEN1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 37.19 kDa
      Observed band size: 45 kDa
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) FEN1 At5g26680 F21E10.3
  • 反應(yīng)種屬:
    Drosophila melanogaster (Fruit fly)
  • 免疫原:
    Recombinant Arabidopsis thaliana FEN1 protein
  • 免疫原種屬:
    Arabidopsis thaliana (Mouse-ear cress)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Protein G
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
  • 基因功能參考文獻(xiàn):
    1. At5g26680 role in mediating transcriptional gene silencing as well as maintaining genome stability PMID: 27231839
    2. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity. PMID: 26721386
  • 亞細(xì)胞定位:
    Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion.
  • 蛋白家族:
    XPG/RAD2 endonuclease family, FEN1 subfamily
  • 數(shù)據(jù)庫(kù)鏈接:

    KEGG: ath:AT5G26680

    STRING: 3702.AT5G26680.1

    UniGene: At.47103



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