在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FEM1B Antibody, Biotin conjugated

  • 中文名稱:
    FEM1B兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA891718LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FEM1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FEM1B
  • 別名:
    F1A alpha antibody; F1A-alpha antibody; F1AA antibody; Fem-1-like death receptor-binding protein alpha antibody; Fem-1-like in apoptotic pathway protein alpha antibody; Fem1 homolog b antibody; FEM1 like death receptor binding protein antibody; FEM1-beta antibody; FEM1b antibody; FEM1B_HUMAN antibody; Protein fem-1 homolog B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein fem-1 homolog B protein (400-627AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation. Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity. Promotes ubiquitination and degradation of ANKRD37. Promotes ubiquitination and degradation of SLBP. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
  • 基因功能參考文獻:
    1. FEM1 proteins are ancient regulators of Stem-Loop Binding Protein. PMID: 28118078
    2. These findings have implications for understanding the cellular functions of Fem1b, and the regulation of Gli1 oncoprotein activity. PMID: 24076122
    3. the proapoptotic protein Fem1b is downregulated by the proteasome in malignant colon cancer cells and mediates proteasome inhibitor-induced apoptosis of these cells PMID: 19908242
    4. This study presents evidence suggesting a role for FEM1A and FEM1B in the pathogenesis of polycystic ovary syndrome. Only FEM1B variants were associated with insulin-related traits in PCOS women. PMID: 18757445
    5. FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. PMID: 19330022

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Fem-1 family
  • 組織特異性:
    Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
  • 數據庫鏈接:

    HGNC: 3649

    OMIM: 613539

    KEGG: hsa:10116

    STRING: 9606.ENSP00000307298

    UniGene: Hs.362733



主站蜘蛛池模板: 99无码熟妇丰满人妻啪啪| 久久久无码精品国产一区| 中国少妇偷人hd| 国产午夜精品一区二区三区四区| 成人免费xxxxx在线观看| 18禁无码永久免费无限制网站| 国产成人亚洲综合无码品善网| 亚洲精品久久久久中文字幕二区 | 蜜臀av国产精品久久久久| 人妻少妇熟女javhd| 久久aaaa片一区二区| 亚洲中文字幕精品久久久久久动漫 | 女人被黑人狂躁c到高潮小说| 国产精品卡一卡二卡三| 久久亚洲精品无码gv| 国产成人一区二区三区免费| 色婷婷美国农夫综合激情亚洲| 亚洲va无码专区国产乱码| 亚洲a∨精品永久无码| 中文字幕久热精品视频在线| 天天躁日日躁很很很躁| 国内裸体无遮挡免费视频| 亚洲精品无码久久久久av老牛| 一本加勒比hezyo无码人妻| 国产精品天干天干综合网| 99久久精品国产成人综合| 欲妇荡岳丰满少妇岳| 精品免费国产一区二区三区四区| 偷看少妇自慰xxxx| 国产最新精品自产在线观看| 草草浮力地址线路①屁屁影院| 先锋影音最新色资源站| 亚洲中文字幕久久精品无码va | 欧美三级在线播放| 艳妇臀荡乳欲伦69调教视频| 精品国产乱码久久久久久乱码| 伊人久久亚洲综合影院首页| 欧美一区二区三区啪啪| www国产亚洲精品久久| 日韩放荡少妇无码视频| 国产麻豆天美果冻无码视频|