在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FEM1B Antibody, Biotin conjugated

  • 中文名稱:
    FEM1B兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA891718LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FEM1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FEM1B
  • 別名:
    F1A alpha antibody; F1A-alpha antibody; F1AA antibody; Fem-1-like death receptor-binding protein alpha antibody; Fem-1-like in apoptotic pathway protein alpha antibody; Fem1 homolog b antibody; FEM1 like death receptor binding protein antibody; FEM1-beta antibody; FEM1b antibody; FEM1B_HUMAN antibody; Protein fem-1 homolog B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein fem-1 homolog B protein (400-627AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation. Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity. Promotes ubiquitination and degradation of ANKRD37. Promotes ubiquitination and degradation of SLBP. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
  • 基因功能參考文獻:
    1. FEM1 proteins are ancient regulators of Stem-Loop Binding Protein. PMID: 28118078
    2. These findings have implications for understanding the cellular functions of Fem1b, and the regulation of Gli1 oncoprotein activity. PMID: 24076122
    3. the proapoptotic protein Fem1b is downregulated by the proteasome in malignant colon cancer cells and mediates proteasome inhibitor-induced apoptosis of these cells PMID: 19908242
    4. This study presents evidence suggesting a role for FEM1A and FEM1B in the pathogenesis of polycystic ovary syndrome. Only FEM1B variants were associated with insulin-related traits in PCOS women. PMID: 18757445
    5. FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. PMID: 19330022

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Fem-1 family
  • 組織特異性:
    Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
  • 數據庫鏈接:

    HGNC: 3649

    OMIM: 613539

    KEGG: hsa:10116

    STRING: 9606.ENSP00000307298

    UniGene: Hs.362733



主站蜘蛛池模板: 激情人妻另类人妻伦| 中文字幕人妻偷伦在线视频| 亚洲人成伊人成综合网久久久| 色偷偷888欧美精品久久久| 图片区小说区激情区偷拍区| 在线观看潮喷失禁大喷水无码| 欧美性大战xxxxx久久久√| 国产一区二区三区免费观看在线| 韩产日产国产欧产| 人人做人人爽国产视| 免费无码久久成人网站入口| 真人抽搐一进一出视频| 日本不卡一区二区三区在线| 久久99久久99小草精品免视看 | 免费无码又爽又刺激高潮的app| 一本大道东京热无码aⅴ| 欧美综合自拍亚洲综合图片区| 久久久噜噜噜久久熟女色| 久久av高潮av无码av喷吹| 欧美成人精品第一区二区三区| 亚洲精品1卡2卡三卡4卡乱码| 黑人巨大白妞出浆| 男女啪动最猛动态图| 欧美人与禽zoz0性伦交| 成年免费视频播放网站推荐| 国产福利免费视频不卡| 精品高潮呻吟99av无码视频| 中文午夜乱理片无码| 成人无码午夜在线观看| 国产福利视频在线观看| 国产69精品久久久久app下载| 欧美婷婷六月丁香综合| 一本久久精品一区二区| 国产一区二区三区四区五区加勒比| 国产 | 欧洲野花视频欧洲1| 天堂在线.www天堂在线资源| 欧美日本国产va高清cabal| 免费看又黄又爽又猛的视频软件| 亚洲中文精品久久久久久| 国产精品美女久久久久久久久| 97夜夜澡人人爽人人喊a|