在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FEM1B Antibody

  • 中文名稱:
    FEM1B兔多克隆抗體
  • 貨號(hào):
    CSB-PA891718LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, Mouse heart tissue
      All lanes: FEM1B antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 71 kDa
      Observed band size: 71 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FEM1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FEM1B
  • 別名:
    F1A alpha antibody; F1A-alpha antibody; F1AA antibody; Fem-1-like death receptor-binding protein alpha antibody; Fem-1-like in apoptotic pathway protein alpha antibody; Fem1 homolog b antibody; FEM1 like death receptor binding protein antibody; FEM1-beta antibody; FEM1b antibody; FEM1B_HUMAN antibody; Protein fem-1 homolog B antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Protein fem-1 homolog B protein (400-627AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,F(xiàn)EM1B Antibody (CSB-PA891718LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于FEM1B Antibody,我們還提供其他標(biāo)記。見(jiàn)下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA891718LB01HU FEM1B Antibody, HRP conjugated ELISA
    FITC CSB-PA891718LC01HU FEM1B Antibody, FITC conjugated
    Biotin CSB-PA891718LD01HU FEM1B Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation. Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity. Promotes ubiquitination and degradation of ANKRD37. Promotes ubiquitination and degradation of SLBP. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
  • 基因功能參考文獻(xiàn):
    1. FEM1 proteins are ancient regulators of Stem-Loop Binding Protein. PMID: 28118078
    2. These findings have implications for understanding the cellular functions of Fem1b, and the regulation of Gli1 oncoprotein activity. PMID: 24076122
    3. the proapoptotic protein Fem1b is downregulated by the proteasome in malignant colon cancer cells and mediates proteasome inhibitor-induced apoptosis of these cells PMID: 19908242
    4. This study presents evidence suggesting a role for FEM1A and FEM1B in the pathogenesis of polycystic ovary syndrome. Only FEM1B variants were associated with insulin-related traits in PCOS women. PMID: 18757445
    5. FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. PMID: 19330022

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Fem-1 family
  • 組織特異性:
    Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3649

    OMIM: 613539

    KEGG: hsa:10116

    STRING: 9606.ENSP00000307298

    UniGene: Hs.362733



主站蜘蛛池模板: 性欧美丰满熟妇xxxx性| 2021在线不卡国产麻豆| 色94色欧美sute亚洲线路二| 国产综合色在线视频区| 精品无人区码一码二码三码区别| 亚洲中字幕日产av片在线| 加勒比东京热无码一区| 国产又粗又硬又大爽黄老大爷视频 | 亚洲va在线va天堂xx xx| 18岁日韩内射颜射午夜久久成人| 国产尤物在线视精品在亚洲| 国产精品三级一区二区| 国产精品嫩草影院av| 欧美成人精品福利视频| 欧美成人高清视频a在线看| 黑人强辱丰满的人妻熟女| 欧美人与动牲交zooz乌克兰| 尹人香蕉久久99天天拍欧美p7| 美女露出粉嫩小奶头在视频18禁| 久久久久波多野结衣高潮| b站永久免费看片大全| 国产精品毛片完整版视频| 超caopor在线公开视频| 吃奶呻吟打开双腿做受视频| 国产精品久久久久9999| 人妻教师痴汉电车波多野结衣| 国产精品亚洲二区在线播放| 中文字幕丝袜第1页| 久久久久国色av免费看| 女人被狂躁60分钟视频| 97国语精品自产拍在线观看| 又色又爽又黄的视频国内| 国产男女爽爽爽免费视频| 亚洲暴爽av天天爽日日碰| 国产午夜无码福利在线看网站| 久久精品午夜福利| 国产草莓精品国产av片国产| 97热久久免费频精品99| 人妻av中文字幕无码专区| 日本真人做爰免费的视频| 国精产品一品二品国精品69xx|