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FANCC Antibody

  • 中文名稱:
    FANCC兔多克隆抗體
  • 貨號:
    CSB-PA008415LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, NIH/3T3 whole cell lysate
      All lanes: FANCC antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 64 kDa
      Observed band size: 64 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA008415LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA008415LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FANCC Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FANCC
  • 別名:
    bA80I15.1 antibody; FA 3 antibody; FA3 antibody; FAC antibody; FACC antibody; FANCC antibody; FANCC_HUMAN antibody; Fanconi anemia complementation group C antibody; Fanconi anemia complementation group C protein antibody; Fanconi anemia group C protein antibody; Fanconi pancytopenia type 3 antibody; FLJ14675 antibody; Protein FACC antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Fanconi anemia group C protein (1-210AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,FANCC Antibody (CSB-PA008415LA01HU),的標記方式是Non-conjugated。對于FANCC Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA008415LB01HU FANCC Antibody, HRP conjugated ELISA
    FITC CSB-PA008415LC01HU FANCC Antibody, FITC conjugated
    Biotin CSB-PA008415LD01HU FANCC Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
  • 基因功能參考文獻:
    1. mutation IVS4+4A>T is the most prevalent mutation in our group of patients. This analysis of Pakistani patients also suggests that there is no significant difference between IVS4+4A>T homozygotes and the rest of the patients with regard to severity of clinical phenotype. PMID: 28425259
    2. The finding that FANCC overexpression reduced betacell apoptosis advances the potential for an alternative approach to the treatment of Diabetes mellitus caused by FANCC defects PMID: 29901137
    3. Lung adenocarcinomas in both male and female patients were associated with (a) genotypic polymorphisms of FANCC and FANCD1. PMID: 26842001
    4. Israeli ATM, BLM, and FANCC heterozygous mutation carriers are not at an increased risk for developing cancer. PMID: 26778106
    5. FANCC interacts and co-localizes with STMN1 at centrosomes during mitosis. We also showed that FANCC is required for STMN1 phosphorylation. PMID: 26466335
    6. FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A. PMID: 24676280
    7. The successful in vitro repair of the mutated Fanconi anemia FANCC gene using the CRISPR/Cas9 system has been described. PMID: 25545896
    8. deregulations of the FANCC-mediated DNA damage repair pathway and the PTCH1-associated sonic hedgehog pathway are associated with the development of early dysplastic head and neck lesions. PMID: 21861228
    9. we identified faults in two genes, Fanconi C and Bloom helicase( FANCC and BLM), in six families. Faults in these genes appear to increase the risk of developing breast cancer PMID: 23028338
    10. FANCC polymorphisms might be associated with the obstructive symptoms in allergic diseases. PMID: 21670957
    11. FA DNA repair genes, FANCD2, FANCL, and FANCC, are transcriptionally upregulated differently in melanoma compared with non-melanoma skin cancer PMID: 21697891
    12. genetic diversity in FANCA, FANCC and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population. PMID: 21543111
    13. Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in Fanconi anemia patients and is enhanced by delivery of suppressor U1 snRNAs. PMID: 20869034
    14. we identified a hepatocellular carcinoma cell line harboring an inactivating mutation of the FANCC gene, specifically causing proximal FA pathway inactivation and the classic cellular DNA interstrand-crosslinking agents-hypersensitivity phenotype PMID: 20509860
    15. study found genetic interaction between Fanconi anemia(FA)gene FANCC and Ku70; results indicate FA pathway promotes homologous recombination repair of DNA double-strand breaks (DSBs) by counteracting Ku70; suggest this achieved by modification of DSBs PMID: 20538911
    16. The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of this protein. PMID: 12239156
    17. Hsp70 requires the cooperation of FANCC to suppress PKR activity and support survival of hematopoietic cells and FANCC does not require the multimeric Fanconi anemia complex to exert this function PMID: 12397061
    18. Fancc-/- phenotypically defined cell populations enriched for hematopoietic stem and progenitor cells exhibit increased cycling PMID: 12763929
    19. FANCC undergoes proteolytic modification by a caspase into a predominant 47-kDa ubiquitinated protein fragment. Lack of proteolytic modification at the putative cleavage site delays apoptosis. PMID: 14625294
    20. Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation. PMID: 15077170
    21. Inappropriate activation of Protein kinase regulated by RNA may cause mutations in FANCC> PMID: 15299030
    22. Data show that the Fanconi anemia protein FANCC cooperate with key mutagenesis and repair processes that enable replication of damaged DNA. PMID: 15327776
    23. spontaneous SCE levels were elevated approximately 2-fold in cells deficient in Fanconi anemia gene FANCC PMID: 15616572
    24. FANCC, FANCE, and FANCD2 form a ternary complex in the Fanconi anemia DNA damage response pathway PMID: 16127171
    25. analysis of two new mutations that inactivate the function of the FANCC protein PMID: 16429406
    26. nuclear accumulation of FANCE does not rely solely on its nuclear localization signal motifs, but also on FANCC PMID: 16513431
    27. FANCC-deficient cells are hypersensitive to DNA cross-linking reagents. PMID: 17490643
    28. We found six differentially expressed proteins; among them, the checkpoint mediator protein MDC1 whose expression was disrupted in FANCC-/- cells. PMID: 17977515
    29. the first report to describe hypermethylation of FANCL in leukemia PMID: 18607065
    30. Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis. PMID: 18990233

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  • 相關疾病:
    Fanconi anemia complementation group C (FANCC)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 3584

    OMIM: 227645

    KEGG: hsa:2176

    STRING: 9606.ENSP00000289081

    UniGene: Hs.494529



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