在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FANCC Antibody

  • 中文名稱:
    FANCC兔多克隆抗體
  • 貨號:
    CSB-PA008415GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FANCC
  • 別名:
    bA80I15.1 antibody; FA 3 antibody; FA3 antibody; FAC antibody; FACC antibody; FANCC antibody; FANCC_HUMAN antibody; Fanconi anemia complementation group C antibody; Fanconi anemia complementation group C protein antibody; Fanconi anemia group C protein antibody; Fanconi pancytopenia type 3 antibody; FLJ14675 antibody; Protein FACC antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human FANCC
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
  • 基因功能參考文獻:
    1. mutation IVS4+4A>T is the most prevalent mutation in our group of patients. This analysis of Pakistani patients also suggests that there is no significant difference between IVS4+4A>T homozygotes and the rest of the patients with regard to severity of clinical phenotype. PMID: 28425259
    2. The finding that FANCC overexpression reduced betacell apoptosis advances the potential for an alternative approach to the treatment of Diabetes mellitus caused by FANCC defects PMID: 29901137
    3. Lung adenocarcinomas in both male and female patients were associated with (a) genotypic polymorphisms of FANCC and FANCD1. PMID: 26842001
    4. Israeli ATM, BLM, and FANCC heterozygous mutation carriers are not at an increased risk for developing cancer. PMID: 26778106
    5. FANCC interacts and co-localizes with STMN1 at centrosomes during mitosis. We also showed that FANCC is required for STMN1 phosphorylation. PMID: 26466335
    6. FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A. PMID: 24676280
    7. The successful in vitro repair of the mutated Fanconi anemia FANCC gene using the CRISPR/Cas9 system has been described. PMID: 25545896
    8. deregulations of the FANCC-mediated DNA damage repair pathway and the PTCH1-associated sonic hedgehog pathway are associated with the development of early dysplastic head and neck lesions. PMID: 21861228
    9. we identified faults in two genes, Fanconi C and Bloom helicase( FANCC and BLM), in six families. Faults in these genes appear to increase the risk of developing breast cancer PMID: 23028338
    10. FANCC polymorphisms might be associated with the obstructive symptoms in allergic diseases. PMID: 21670957
    11. FA DNA repair genes, FANCD2, FANCL, and FANCC, are transcriptionally upregulated differently in melanoma compared with non-melanoma skin cancer PMID: 21697891
    12. genetic diversity in FANCA, FANCC and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population. PMID: 21543111
    13. Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in Fanconi anemia patients and is enhanced by delivery of suppressor U1 snRNAs. PMID: 20869034
    14. we identified a hepatocellular carcinoma cell line harboring an inactivating mutation of the FANCC gene, specifically causing proximal FA pathway inactivation and the classic cellular DNA interstrand-crosslinking agents-hypersensitivity phenotype PMID: 20509860
    15. study found genetic interaction between Fanconi anemia(FA)gene FANCC and Ku70; results indicate FA pathway promotes homologous recombination repair of DNA double-strand breaks (DSBs) by counteracting Ku70; suggest this achieved by modification of DSBs PMID: 20538911
    16. The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of this protein. PMID: 12239156
    17. Hsp70 requires the cooperation of FANCC to suppress PKR activity and support survival of hematopoietic cells and FANCC does not require the multimeric Fanconi anemia complex to exert this function PMID: 12397061
    18. Fancc-/- phenotypically defined cell populations enriched for hematopoietic stem and progenitor cells exhibit increased cycling PMID: 12763929
    19. FANCC undergoes proteolytic modification by a caspase into a predominant 47-kDa ubiquitinated protein fragment. Lack of proteolytic modification at the putative cleavage site delays apoptosis. PMID: 14625294
    20. Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation. PMID: 15077170
    21. Inappropriate activation of Protein kinase regulated by RNA may cause mutations in FANCC> PMID: 15299030
    22. Data show that the Fanconi anemia protein FANCC cooperate with key mutagenesis and repair processes that enable replication of damaged DNA. PMID: 15327776
    23. spontaneous SCE levels were elevated approximately 2-fold in cells deficient in Fanconi anemia gene FANCC PMID: 15616572
    24. FANCC, FANCE, and FANCD2 form a ternary complex in the Fanconi anemia DNA damage response pathway PMID: 16127171
    25. analysis of two new mutations that inactivate the function of the FANCC protein PMID: 16429406
    26. nuclear accumulation of FANCE does not rely solely on its nuclear localization signal motifs, but also on FANCC PMID: 16513431
    27. FANCC-deficient cells are hypersensitive to DNA cross-linking reagents. PMID: 17490643
    28. We found six differentially expressed proteins; among them, the checkpoint mediator protein MDC1 whose expression was disrupted in FANCC-/- cells. PMID: 17977515
    29. the first report to describe hypermethylation of FANCL in leukemia PMID: 18607065
    30. Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis. PMID: 18990233

    顯示更多

    收起更多

  • 相關疾病:
    Fanconi anemia complementation group C (FANCC)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 3584

    OMIM: 227645

    KEGG: hsa:2176

    STRING: 9606.ENSP00000289081

    UniGene: Hs.494529



主站蜘蛛池模板: 少妇被爽到高潮喷水久久欧美精品| 久久精品国产99久久丝袜蜜桃| 国产未发育呦交视频| 亚洲国产激情一区二区三区| 中美日韩毛片免费播放| 天天天天躁天天爱天天碰 | 亚洲人成人无码www影院 | 伊人久久精品亚洲午夜| 亚洲午夜精品久久久久久app| 亚洲精品日本久久一区二区三区| 樱花草在线社区www| 97无码免费人妻超级碰碰夜夜| 伊伊人成亚洲综合人网| 国产一卡二卡三新区2022| 亚洲线精品一区二区三区影音先锋| 国产精品久久久久久无毒不卡 | 女上男下啪啪激烈高潮无遮盖| 在线中文字幕亚洲日韩2020| 国产人妖视频一区二区| 亚洲s码欧洲m码国产av| 婷婷五月综合丁香在线| 亚洲六月丁香六月婷婷| 丰满人妻熟妇乱偷人无码| 精品无码日韩一区二区三区不卡| 又大又粗又爽免费视频a片| 奶头好大狂揉60分钟视频| 成人欧美一区二区三区的电影| 欧美国产日韩a在线视频| 中文无码伦av中文字幕在线| 成人网站www污污污网站 | 久久亚洲精品成人av无码网站| 国产精品午夜福利不卡120| 激情无码人妻又粗又大中国人| 久久99精品国产麻豆婷婷洗澡| 精产国品一二三产区m553麻豆 | 国产大量精品视频网站| 少妇一晚三次一区二区三区| 亚洲啪啪综合av一区| 韩国午夜福利片在线观看| 性xxxxx欧美极品少妇| 五月丁香综合激情六月久久|