在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EZH1 Antibody

  • 中文名稱:
    EZH1兔多克隆抗體
  • 貨號:
    CSB-PA002349
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COS7 cells using ENX-2 Polyclonal Antibody
    • Western Blot analysis of HT29 LOVO A549 NIH-3T3 cells using ENX-2 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Enhancer of zeste homolog 1 (Drosophila) antibody; Enhancer of zeste homolog 1 antibody; ENX-2 antibody; ENX2 antibody; Ezh1 antibody; EZH1_HUMAN antibody; Histone-lysine N-methyltransferase EZH1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Monkey
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human ENX-2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
  • 基因功能參考文獻:
    1. identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo PMID: 29342143
    2. pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. PMID: 28701475
    3. Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages. PMID: 28939884
    4. Expression of the EZH2 homolog EZH1 is reduced in EZH2-deficient CML LICs, creating a scenario resembling complete loss of PRC2. EZH2 dependence of CML LICs raises prospects for improved therapy of TKI-resistant CML and/or eradication of disease by addition of EZH2 inhibitors PMID: 27630126
    5. a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID: 27500488
    6. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
    7. The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes. PMID: 28346433
    8. These evidences suggest that EZH2 and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas PMID: 27311868
    9. The related enzymatic subunits EZH1 and EZH2 undergo an expression switch during blood cell development. PMID: 25578878
    10. EZH1 maintains repressive chromatin through different mechanisms. PMID: 19026781

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
  • 數據庫鏈接:

    HGNC: 3526

    OMIM: 601674

    KEGG: hsa:2145

    STRING: 9606.ENSP00000404658

    UniGene: Hs.194669



主站蜘蛛池模板: 色妺妺免费影院| 无码av中文字幕久久专区 | 一区二区在线 | 欧洲| 国产区女主播在线观看| 日日噜噜夜夜狠狠久久无码区| 中国性欧美videofree精品| 大伊香蕉精品一区二区| 国产精品永久在线观看| 久久精品丝袜高跟鞋| 丁香婷婷无码不卡在线| 在线 | 国产精品99传媒丿| 国产亚洲精品成人aa片新蒲金| 久久综合亚洲色hezyo社区| 一区二区三区在线 | 欧| 国产高清卡1卡2卡3麻豆| 无码人妻斩一区二区三区| 国产熟妇另类久久久久| 日韩精品无码一区二区中文字幕| 老湿机国产福利视频| 久久国产福利播放| 自拍偷自拍亚洲精品情侣| 色护士极品影院| 亚洲欲色欲色xxxxx在线观看 | 亚洲欧洲综合有码无码| 亚洲国产a∨无码中文777| 激情五月婷婷| 亚洲欧洲专线一区| 免费看成人午夜福利专区| 国产精品卡一卡2卡三卡网站| 久久99精品久久久久子伦| 免费体验区试看120秒| 亚洲中文字幕无码mv| 日产精品一卡2卡三卡4乱码| 国语自产精品视频在线看 | 国产精品熟妇视频国产偷人| 动漫av永久无码精品每日更新| 在线播放亚洲人成电影| 国产成人综合在线视频| 欧美深性狂猛ⅹxxx深喉| 欧美极p品少妇的xxxxx| 人妻三级日本香港三级极97|