在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EZH1 Antibody

  • 中文名稱:
    EZH1兔多克隆抗體
  • 貨號:
    CSB-PA007912GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Enhancer of zeste homolog 1 (Drosophila) antibody; Enhancer of zeste homolog 1 antibody; ENX-2 antibody; ENX2 antibody; Ezh1 antibody; EZH1_HUMAN antibody; Histone-lysine N-methyltransferase EZH1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human EZH1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
  • 基因功能參考文獻:
    1. identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo PMID: 29342143
    2. pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. PMID: 28701475
    3. Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages. PMID: 28939884
    4. Expression of the EZH2 homolog EZH1 is reduced in EZH2-deficient CML LICs, creating a scenario resembling complete loss of PRC2. EZH2 dependence of CML LICs raises prospects for improved therapy of TKI-resistant CML and/or eradication of disease by addition of EZH2 inhibitors PMID: 27630126
    5. a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID: 27500488
    6. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
    7. The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes. PMID: 28346433
    8. These evidences suggest that EZH2 and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas PMID: 27311868
    9. The related enzymatic subunits EZH1 and EZH2 undergo an expression switch during blood cell development. PMID: 25578878
    10. EZH1 maintains repressive chromatin through different mechanisms. PMID: 19026781

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
  • 數據庫鏈接:

    HGNC: 3526

    OMIM: 601674

    KEGG: hsa:2145

    STRING: 9606.ENSP00000404658

    UniGene: Hs.194669



主站蜘蛛池模板: 中文字幕乱码免费专区| 亚洲国产成人久久综合三区| 日韩精品无码免费一区二区三区 | 亚洲欧洲精品无码av| 亚洲一区二区三区含羞草| 成人18禁深夜福利网站app免费| 真实国产老熟女无套中出| 国产精品乱码在线观看| 综合无码精品人妻一区二区三区 | 国产成人精品午夜福利| 久久久www成人免费精品| 久久久国产99久久国产久麻豆| 国产一区二区三区不卡在线看| 国产亚洲精品俞拍视频| 伊人蕉久中文字幕无码专区| 亚洲暴爽av人人爽日日碰| 久久久一本精品久久精品六六| 初尝黑人巨砲波多野结衣| 美女视频黄a视频全免费| 98视频精品全部国产| 国内少妇偷人精品视频| 在线成人精品国产区免费| 久久精品一区二区三区av| 久久婷婷五月综合色和| 国产精品aⅴ视频在线播放| 66lu国产在线观看| 国产精品久久久亚洲| 国内精品久久久久影视| 强行从后面挺进人妻| 中文区中文字幕免费看| 丰满爆乳在线播放| 亚洲中文无码av永久伊人| 中文字幕在线精品视频| ww国产内射精品后入国产| 国产av高清无亚洲| 久久中文精品无码中文字幕下载| 性史性农村dvd毛片| 少妇一夜三次一区二区| 国产美熟女乱又伦av果冻传媒| 国产精品美女久久久网站| 蜜桃av色偷偷av老熟女|