在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ETS2 Antibody

  • 中文名稱:
    ETS2兔多克隆抗體
  • 貨號:
    CSB-PA007853LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Mouse liver tissue, Mouse brain tissue
      All lanes: ETS2 antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 54 kDa
      Observed band size: 54 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ETS2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    C ets 2 protein antibody; ETS2 antibody; ETS2_HUMAN antibody; ETS2IT1 antibody; Oncogene ETS 2 antibody; Oncogene ETS2 antibody; Protein C-ets-2 antibody; v ets avian erythroblastosis virus E2 oncogene homolog 2 antibody; V ets avian erythroblastosis virus E26 oncogene homolog 2 antibody; V ets erythroblastosis virus E26 oncogene homolog 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Protein C-ets-2 protein (9-185AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ETS2 Antibody (CSB-PA007853LA01HU),的標記方式是Non-conjugated。對于ETS2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA007853LB01HU ETS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA007853LC01HU ETS2 Antibody, FITC conjugated
    Biotin CSB-PA007853LD01HU ETS2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
  • 基因功能參考文獻:
    1. ETS2 is of potential value as a molecular target for RCC treatment. PMID: 29772431
    2. ETS2 functions as an oncogene and plays a key role in the progression of hypopharyngeal cancer. PMID: 29111780
    3. ETS2 (high) is a poor prognostic factor in acute myeloid leukemia and may guide treatment decisions towards allogeneic hematopoietic stem cell transplantation. PMID: 28724426
    4. Findings strongly suggest a critical role of Ets2 in human esophageal squamous cell carcinoma pathogenesis via the inactivation of the mTOR/p70S6K signaling pathway. PMID: 27556183
    5. Authors demonstrate that mtp53 prevents the COP1/DET1 complex from ubiquitinating ETS2 and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 complex thereby preventing ETS2 degradation. PMID: 26871468
    6. These findings suggest that ETS2 rs461155A>G, could be used as a biomarker predicting the clinical outcomes of non-small cell lung cancer patients treated with first-line paclitaxel-cisplatin chemotherapy. PMID: 26893365
    7. These results suggest an unappreciated role for ETS2 in fibroblasts in establishing an immune-suppressive microenvironment in response to oncogenic Kras(G12D) signaling during the initial stages of tumor development. PMID: 27659014
    8. ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 PMID: 27048589
    9. Neuronal C-ETS2 senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes. PMID: 27195074
    10. ETS2, HNF4A and JUNB are synergistic master regulators of epithelial-to-mesenchymal transition in cancer. PMID: 26926107
    11. ATO treatment upregulated Ets-2 and miR-126 expression in HUVECs. PMID: 26274316
    12. RNA-seq evidence of biallelic expression of ETS2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of ETS2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
    13. ETS-1/ETS-2 and C/EBPalpha could interact with corresponding binding sites. PMID: 25726912
    14. These data suggested that Ets-2, a genuine cancer-specific transcription factor, is actively involved in EGFR kinase-induced hTERT overexpression pathway in lung cancer cells. PMID: 25680408
    15. The crystal structure of a DNA complex of the Ets-2 Ets domain. PMID: 25670864
    16. identified Ets2 as a key novel regulator in both the positive and negative control of miR-155 in the inflammatory response. PMID: 24362029
    17. The data reveals a key function for Ets2 in tumor fibroblasts in signaling to endothelial cells to promote tumor angiogenesis. PMID: 23977064
    18. Our findings point to a tumor suppressor role for ETS2 in human NSCLC pathogenesis through inhibition of the MET proto-oncogene. PMID: 23659968
    19. hepatitis B virus core protein enhanced the promoter activity of human telomerase reverse transcriptase, which was dependent on the binding of c-Ets2 to the promoter region PMID: 23542016
    20. the G allele of SNP rs391957 in the promoter of GRP78 was strongly associated with increased hepatocellular carcinoma risk and cis-regulated GRP78 expression by providing an Ets-2 binding site. PMID: 23416888
    21. The Ets2 transcription factor regulates G-CSF expression in human cancer. PMID: 23530240
    22. Altered expression of SIM2 and ETS2 could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome. PMID: 23343470
    23. Data suggest that the regulation of MDR1 expression by ETS2 may provide potential ways to overcome MDR in cancer treatment. PMID: 22819965
    24. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. PMID: 22826236
    25. In embryonic stem cells [which express ETS2 (proto-oncogene c-ETS-2) but not CGA (alpha subunit chorionic gonadotropin)], ETS2 does not occupy binding site on CGA promoter but is found as soluble complex with POU5F1 (Oct3 transcription factor). PMID: 22446105
    26. c-Jun in cooperation with Ets2 increases the expression of Syk and contributes to Syk-mediated heightened calcium responses in systemic lupus erythematosus T cells. PMID: 22354960
    27. demonstrated that miR-196b was transcriptionally regulated by ETS2 and there was an inverse expression profile between miR-196b and ETS2 in clinical samples PMID: 22298639
    28. a stage-specific Ets-1-independent regulatory role for Ets-2 in early thymocyte development and survival PMID: 22128184
    29. rs461155 and rs2073601, in ETS2 and SIM2 genes respectively, showed significant redundant interaction in probands with Down syndrome PMID: 22048266
    30. These data indicate the importance of phosphorylated ets-2 in the pathogenesis of pulmonary fibrosis through the expression of Type I collagen and (myo)fibroblast activation. PMID: 21562315
    31. evidence for the plaque-destabilizing role of Ets2 in atherosclerosis development by induction of an intraplaque proinflammatory phenotype in endothelial cells. PMID: 21700929
    32. data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences PMID: 21763315
    33. Allelic discrimination of deleterious SNPs in ETS2 may play a regulatory role in the differential development of malignancy in Down syndrome subjects. PMID: 21526717
    34. the differential up-regulation of MKP3 by Ets2 and of DUSP5 by c-Jun may converge in similar functional roles for these MAP kinase phosphatases in the growth arrest versus proliferation decisions of breast cancer cells PMID: 20554528
    35. Ets2 is a central driver of a transcriptional program in tumor-associated macrophages that acts to promote lung metastasis of breast tumors. PMID: 20145133
    36. Ets-2 and p53 mediate cAMP- induced trophoblast invasiveness, through regulation of MMP-2. PMID: 19939245
    37. Linkage of elevated expression to hepatocarcinogenesis PMID: 12174931
    38. Two closely spaced Ets-2 binding sites in the proximal promoter of the human chorionic gonadotropin beta5 (hCGbeta5) gene constitute a major enhancer for hCGbeta gene expression in JAr and JEG-3 human choriocarcinoma cells and in mouse NIH3T3 cells. PMID: 12511603
    39. Overexpression of ETS2 in human esophageal squamous cell carcinoma in both mRNA and protein levels. PMID: 12532432
    40. ets-2 has a role as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors PMID: 12637547
    41. ETS2 is a target of protein kinase C and upregulates GM-CSF PMID: 12646185
    42. Ets-2 and its targets play essential roles in endothelial cell function PMID: 14507917
    43. Ras/mitogen-activated kinase signaling activates ETS2 by CBP/p300 recruitment. PMID: 15572696
    44. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer PMID: 15788656
    45. Phosphorylated ERK1/2 was further associated with the presence of VEGFR2 (cohorts II and III) and the degree of phosphorylated Ets-2, indicating in vivo, a signalling cascade from VEGFR2 via ERK1/2 to Ets-2 phosphorylation PMID: 15806151
    46. analysis of Ets2 in cell-seeded three-dimensional bone constructs PMID: 15900611
    47. Data show that transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site. PMID: 16953216
    48. Results suggest that there is a strong interplay of Ets2 with bone-specific proteins in cell-seeded three-dimensional bone constructs. PMID: 17703088
    49. data of study population indicate a higher ETS2 RNA concentration compared with uPA in the case of bladder cancer, resulting in an increased ETS2:uPA RNA ratio in urine PMID: 17921261
    50. Data show that there are combinatorial effects of Ets2, PKA, and CBP/p300 and triggered via growth factors released from maternal endometrium. PMID: 17975022

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ETS family
  • 數據庫鏈接:

    HGNC: 3489

    OMIM: 164740

    KEGG: hsa:2114

    STRING: 9606.ENSP00000353344

    UniGene: Hs.644231



主站蜘蛛池模板: 人与嘼av免费| 老司机性色福利精品视频| 无线乱码一二三区免费看| 狠狠躁天天躁中文字幕无码| 日韩精品成人无码专区免费| 久章草在线精品视频免费观看| 国产欧美另类精品久久久| 亚洲乱码日产精品bd在观看 | 午夜激成人免费视频在线观看| 国产成人精品久久| 人人妻人人妻人人片av| 亚洲中文字幕丝祙制服| 日日碰狠狠添天天爽超碰97| 老熟妇乱子伦牲交视频| 精品夜夜爽欧美毛片视频| 高清不卡毛片免费观看| 亚洲精品无码久久久久秋霞 | 国产欧美日韩精品专区| 欧美人与物videos另类| 红杏亚洲影院一区二区三区| 午夜福利18以下勿进免费| 亚洲人成人无码网www电影首页 | 国产精品久久久久久久久电影网| 无码人妻精品一区二区三| 在教室伦流澡到高潮hgl动漫| 国产大学生粉嫩无套流白浆| 日本高清aⅴ毛片免费| 色先锋资源久久综合5566| 精品性影院一区二区三区内射| 欧美成人一区二区三区在线观看 | 欧美国产日韩亚洲中文| 国产精品喷浆| 亚洲色大成网站www永久网站| 国产美女爽到喷出水来视频| 欧美巨大黑人精品videos| 揉着我的奶从后面进去视频| 日韩丰满少妇无吗视频激情内射| 变态另类先锋影音| 亚洲日韩欧美一区二区三区| 久久天天躁狠狠躁夜夜躁2014| 亚洲中文字幕av无码区|