在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ETS2 Antibody

  • 中文名稱:
    ETS2兔多克隆抗體
  • 貨號:
    CSB-PA908387
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA908387(ETS2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    C ets 2 protein antibody; ETS2 antibody; ETS2_HUMAN antibody; ETS2IT1 antibody; Oncogene ETS 2 antibody; Oncogene ETS2 antibody; Protein C-ets-2 antibody; v ets avian erythroblastosis virus E2 oncogene homolog 2 antibody; V ets avian erythroblastosis virus E26 oncogene homolog 2 antibody; V ets erythroblastosis virus E26 oncogene homolog 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human ETS2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
  • 基因功能參考文獻:
    1. ETS2 is of potential value as a molecular target for RCC treatment. PMID: 29772431
    2. ETS2 functions as an oncogene and plays a key role in the progression of hypopharyngeal cancer. PMID: 29111780
    3. ETS2 (high) is a poor prognostic factor in acute myeloid leukemia and may guide treatment decisions towards allogeneic hematopoietic stem cell transplantation. PMID: 28724426
    4. Findings strongly suggest a critical role of Ets2 in human esophageal squamous cell carcinoma pathogenesis via the inactivation of the mTOR/p70S6K signaling pathway. PMID: 27556183
    5. Authors demonstrate that mtp53 prevents the COP1/DET1 complex from ubiquitinating ETS2 and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 complex thereby preventing ETS2 degradation. PMID: 26871468
    6. These findings suggest that ETS2 rs461155A>G, could be used as a biomarker predicting the clinical outcomes of non-small cell lung cancer patients treated with first-line paclitaxel-cisplatin chemotherapy. PMID: 26893365
    7. These results suggest an unappreciated role for ETS2 in fibroblasts in establishing an immune-suppressive microenvironment in response to oncogenic Kras(G12D) signaling during the initial stages of tumor development. PMID: 27659014
    8. ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 PMID: 27048589
    9. Neuronal C-ETS2 senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes. PMID: 27195074
    10. ETS2, HNF4A and JUNB are synergistic master regulators of epithelial-to-mesenchymal transition in cancer. PMID: 26926107
    11. ATO treatment upregulated Ets-2 and miR-126 expression in HUVECs. PMID: 26274316
    12. RNA-seq evidence of biallelic expression of ETS2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of ETS2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
    13. ETS-1/ETS-2 and C/EBPalpha could interact with corresponding binding sites. PMID: 25726912
    14. These data suggested that Ets-2, a genuine cancer-specific transcription factor, is actively involved in EGFR kinase-induced hTERT overexpression pathway in lung cancer cells. PMID: 25680408
    15. The crystal structure of a DNA complex of the Ets-2 Ets domain. PMID: 25670864
    16. identified Ets2 as a key novel regulator in both the positive and negative control of miR-155 in the inflammatory response. PMID: 24362029
    17. The data reveals a key function for Ets2 in tumor fibroblasts in signaling to endothelial cells to promote tumor angiogenesis. PMID: 23977064
    18. Our findings point to a tumor suppressor role for ETS2 in human NSCLC pathogenesis through inhibition of the MET proto-oncogene. PMID: 23659968
    19. hepatitis B virus core protein enhanced the promoter activity of human telomerase reverse transcriptase, which was dependent on the binding of c-Ets2 to the promoter region PMID: 23542016
    20. the G allele of SNP rs391957 in the promoter of GRP78 was strongly associated with increased hepatocellular carcinoma risk and cis-regulated GRP78 expression by providing an Ets-2 binding site. PMID: 23416888
    21. The Ets2 transcription factor regulates G-CSF expression in human cancer. PMID: 23530240
    22. Altered expression of SIM2 and ETS2 could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome. PMID: 23343470
    23. Data suggest that the regulation of MDR1 expression by ETS2 may provide potential ways to overcome MDR in cancer treatment. PMID: 22819965
    24. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. PMID: 22826236
    25. In embryonic stem cells [which express ETS2 (proto-oncogene c-ETS-2) but not CGA (alpha subunit chorionic gonadotropin)], ETS2 does not occupy binding site on CGA promoter but is found as soluble complex with POU5F1 (Oct3 transcription factor). PMID: 22446105
    26. c-Jun in cooperation with Ets2 increases the expression of Syk and contributes to Syk-mediated heightened calcium responses in systemic lupus erythematosus T cells. PMID: 22354960
    27. demonstrated that miR-196b was transcriptionally regulated by ETS2 and there was an inverse expression profile between miR-196b and ETS2 in clinical samples PMID: 22298639
    28. a stage-specific Ets-1-independent regulatory role for Ets-2 in early thymocyte development and survival PMID: 22128184
    29. rs461155 and rs2073601, in ETS2 and SIM2 genes respectively, showed significant redundant interaction in probands with Down syndrome PMID: 22048266
    30. These data indicate the importance of phosphorylated ets-2 in the pathogenesis of pulmonary fibrosis through the expression of Type I collagen and (myo)fibroblast activation. PMID: 21562315
    31. evidence for the plaque-destabilizing role of Ets2 in atherosclerosis development by induction of an intraplaque proinflammatory phenotype in endothelial cells. PMID: 21700929
    32. data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences PMID: 21763315
    33. Allelic discrimination of deleterious SNPs in ETS2 may play a regulatory role in the differential development of malignancy in Down syndrome subjects. PMID: 21526717
    34. the differential up-regulation of MKP3 by Ets2 and of DUSP5 by c-Jun may converge in similar functional roles for these MAP kinase phosphatases in the growth arrest versus proliferation decisions of breast cancer cells PMID: 20554528
    35. Ets2 is a central driver of a transcriptional program in tumor-associated macrophages that acts to promote lung metastasis of breast tumors. PMID: 20145133
    36. Ets-2 and p53 mediate cAMP- induced trophoblast invasiveness, through regulation of MMP-2. PMID: 19939245
    37. Linkage of elevated expression to hepatocarcinogenesis PMID: 12174931
    38. Two closely spaced Ets-2 binding sites in the proximal promoter of the human chorionic gonadotropin beta5 (hCGbeta5) gene constitute a major enhancer for hCGbeta gene expression in JAr and JEG-3 human choriocarcinoma cells and in mouse NIH3T3 cells. PMID: 12511603
    39. Overexpression of ETS2 in human esophageal squamous cell carcinoma in both mRNA and protein levels. PMID: 12532432
    40. ets-2 has a role as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors PMID: 12637547
    41. ETS2 is a target of protein kinase C and upregulates GM-CSF PMID: 12646185
    42. Ets-2 and its targets play essential roles in endothelial cell function PMID: 14507917
    43. Ras/mitogen-activated kinase signaling activates ETS2 by CBP/p300 recruitment. PMID: 15572696
    44. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer PMID: 15788656
    45. Phosphorylated ERK1/2 was further associated with the presence of VEGFR2 (cohorts II and III) and the degree of phosphorylated Ets-2, indicating in vivo, a signalling cascade from VEGFR2 via ERK1/2 to Ets-2 phosphorylation PMID: 15806151
    46. analysis of Ets2 in cell-seeded three-dimensional bone constructs PMID: 15900611
    47. Data show that transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site. PMID: 16953216
    48. Results suggest that there is a strong interplay of Ets2 with bone-specific proteins in cell-seeded three-dimensional bone constructs. PMID: 17703088
    49. data of study population indicate a higher ETS2 RNA concentration compared with uPA in the case of bladder cancer, resulting in an increased ETS2:uPA RNA ratio in urine PMID: 17921261
    50. Data show that there are combinatorial effects of Ets2, PKA, and CBP/p300 and triggered via growth factors released from maternal endometrium. PMID: 17975022

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ETS family
  • 數據庫鏈接:

    HGNC: 3489

    OMIM: 164740

    KEGG: hsa:2114

    STRING: 9606.ENSP00000353344

    UniGene: Hs.644231



主站蜘蛛池模板: 亚洲自偷自拍另类12p| 熟妇人妻无码xxx视频| 国产美女被遭高潮免费视频 | 偷看少妇自慰xxxx| 国产aⅴ精品一区二区三区尤物| 久久综合久久自在自线精品自| 无码纯肉动漫在线观看| 一个人看的免费视频www中文字幕| 国产乱人偷精品人妻a片| 中文字幕v亚洲ⅴv天堂| 午夜性色吃奶添下面69影院 | 成人动漫综合网| 老熟妇高潮一区二区三区| _97夜夜澡人人爽人人喊_欧美 | 韩国日本三级在线观看| 美女裸体十八禁免费网站| 欧美人禽杂交狂配免费看| 国产精品自在拍一区二区不卡 | 亚洲综合无码久久精品综合| 黑巨人与欧美精品一区| 国产成人亚洲综合图区| 在线观看片a免费不卡观看| 真人性囗交69视频| 最新系列国产专区|亚洲国产| 国产av毛片亚洲含羞草社| 热久久视久久精品18| 97人人模人人爽人人喊网 | 国产精品亚洲a∨天堂| 久久久久久成人毛片免费看| 国产精品成人无码久久久| 国产与黑人在线播放| 性高朝久久久久久久| 国产精品美女久久久网av| 无码少妇一区二区三区芒果| 精品无码专区久久久水蜜桃| а天堂中文在线官网在线 | 精品一区二区三区四区五区六区 | 蜜桃av抽搐高潮一区二区| 国产色视频自在线观看| 日韩内射美女片在线观看网站| 大香伊人久久精品一区二区|