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ERAS Antibody

  • 中文名稱:
    ERAS兔多克隆抗體
  • 貨號:
    CSB-PA599022
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA599022(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA599022(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA599022(ERAS Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ERAS
  • 別名:
    E ras antibody; E-Ras antibody; ecat5 antibody; Embryonic stem cell expressed Ras antibody; Embryonic stem cell-expressed Ras antibody; Eras antibody; ES cell expressed Ras antibody; GTPase ERas antibody; Ha-Ras2 antibody; HRAS2 antibody; HRASP antibody; MGC126691 antibody; MGC126693 antibody; OTTHUMP00000065857 antibody; RASE_HUMAN antibody; Small GTPase protein E Ras antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog pseudogene antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human ERAS
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.
  • 基因功能參考文獻:
    1. N-terminal extension of E-RAS is important for E-RAS signaling activity. PMID: 25940089
    2. Expression of ERAS in human melanoma cell lines conferred resistance to PLX4720 and induced hyperphosphorylation of AKT. PMID: 25624498
    3. After knocking down the ERas gene by siRNA, we observed that there was a significant decrease in proliferation, metastasis as well as clonality in gastric carcinoma. PMID: 23612786
    4. Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas. PMID: 22875024
    5. ERas may be a potential biomarker for gastric cancer, but advanced studies are wanted. PMID: 21151392
    6. These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin. PMID: 20566745
    7. ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma. PMID: 20811723
    8. transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells PMID: 12774123
    9. Studies on ERas gene expression. PMID: 16081664
    10. rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms PMID: 18174262
    11. High ERas is associated with the tumorigenic process of gastric carcinomas. PMID: 19528480
    12. Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer. PMID: 19787253

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  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族:
    Small GTPase superfamily, Ras family
  • 數據庫鏈接:

    HGNC: 5174

    OMIM: 300437

    KEGG: hsa:3266

    STRING: 9606.ENSP00000339136

    UniGene: Hs.447330



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