在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. EPHA7 Antibody, HRP conjugated

EPHA7 Antibody, HRP conjugated

  • 中文名稱：
    EPHA7兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA618004LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) EPHA7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cek 11 antibody; Developmental kinase 1 antibody; EBK antibody; EHK-3 antibody; EHK3 antibody; EK11 antibody; Embryonic brain kinase antibody; EPH homology kinase 3 antibody; EPH-like kinase 11 antibody; Epha7 antibody; EPHA7_HUMAN antibody; Ephrin receptor Eph A7 antibody; Ephrin type A receptor 7 antibody; Ephrin type-A receptor 7 antibody; hEK11 antibody; MDK 1 antibody; Receptor protein tyrosine kinase HEK 11 antibody; Tyrosine protein kinase receptor EHK 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ephrin type-A receptor 7 protein (28-182AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
  • 基因功能參考文獻：
    1. receptor phosphorylation of EphA7, at least in part, suppress prostate cancer tumor malignancy through targeting PI3K/Akt signaling pathways. PMID: 29022918
    2. these findings suggest that miR-448 functioned as a tumor suppressor gene in the development of osteosarcoma through targeting EPHA7. PMID: 28604772
    3. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness. PMID: 27566654
    4. Eph receptor A7 may have an important role in the pathogenesis of nonsmall cell lung cancer by regulating PTEN expression via thephosphatase and tensin homolog/AKT pathway. PMID: 26936314
    5. Depletion of EphA7 remarkably inhibited the proliferation and invasion of Hep-2 and AMC-HN-8 cells in comparison to control and EphA7 siRNA negative control (NC)-transfected cells. PMID: 25968442
    6. Authors observed that the extracellular region of the EphA7 receptor was critical for interacting with caspase-8, whereas the cytoplasmic region of EphA7 was not. PMID: 25855521
    7. miR-137 is able to directly bind to the EPHA7 3'UTR and negatively regulate the expression of EPHA7 in HUVECs. PMID: 24927112
    8. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. PMID: 21964981
    9. The expression of EphA7 and/or MTDH might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma. PMID: 21609571
    10. Overexpression of EphA7 and/or MTDH might indicate poor prognosis in squamous cell cancer of the tongue. PMID: 22246354
    11. EPHA7 acts as a tumor suppressor in vivo and is targeted by genomic deletions and differential epigenetic silencing in human lymphomas. PMID: 22036564
    12. EphA7 protein expression is significantly correlated with the biological behavior of primary hepatocellular carcinoma. PMID: 20302756
    13. analysis of the secreted form of EphA7 in lung cancer PMID: 20126984
    14. downregulation of an Eph family gene in a solid tumor via aberrant 5'CpG island methylation, providing evidence that EphA7 gene is involved in human colorectal carcinogenesis PMID: 16007213
    15. EphA7 expression in 52 gastric carcinoma was consistent with its transcript expression, with the protein being significantly overexpressed in younger patients (P = .016) and in patients with advanced tumors (P = .033) PMID: 17669470
    16. siRNA-mediated suppression of ALL1/AF4 in SEMK2 cells carrying the t(4;11) chromosome translocation resulted in down-regulation of EphA7 PMID: 17726105
    17. EphA7 protein may have a role in progression of glioblastoma multiforme PMID: 18366728
    18. epigenetic inactivation of EphA7 may be involved in prostate carcinogenesis PMID: 18821581

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3390

    OMIM: 602190

    KEGG: hsa:2045

    STRING: 9606.ENSP00000358309

    UniGene: Hs.73962



主站蜘蛛池模板： 美女扒开尿口让男人桶| 宅男宅女精品国产av天堂| 午夜爽爽爽男女免费观看麻豆国产| 日本欧美大码a在线观看| 欧美群妇大交群| 色avav色av爱avav亚洲色拍| 色噜噜狠狠一区二区三区果冻| 国产熟女高潮视频| 狠狠色狠狠色五月激情| www夜片内射视频日韩精品成人| 国产又粗又猛又爽又黄的视频在线观看动漫 | 无码中文字幕日韩专区| 亚洲国产精品一区二区成人片国内| 在教室伦流澡到高潮h麻豆| 九个美女露脸撒尿嘘嘘视频| 欧美老妇交乱视频在线观看 | 欧美大波少妇在厨房被| 亚洲爆乳无码专区www| 亚洲 中文字幕 日韩 无码| 久久综合国产乱子伦精品免费| 国产边摸边吃奶边做爽视频| 国产精品无码一区二区三区电影| 97久久人人超碰国产精品| 成人精品视频在线观看不卡| 亚洲色成人www永久网站| 亚洲中文字幕久久精品无码喷水| 午夜国产成人片在线播放| 猫咪www免费人成网站无码| 无码av无码天堂资源网| 少妇久久久久久被弄高潮| 亚洲人成线无码7777| 久久无码中文字幕无码| 香港日本三级亚洲三级| 精品国产不卡一区二区三区| 播放灌醉水嫩大学生国内精品| 久久超碰极品视觉盛宴| 热の综合热の国产热の潮在线| 性欧美牲交在线视频| 欧美丰满少妇xxxx性| 国产欠欠欠18一区二区| 亚洲中文字幕无码久久|