在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EPHA7 Antibody, Biotin conjugated

  • 中文名稱:
    EPHA7兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA618004LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EPHA7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Cek 11 antibody; Developmental kinase 1 antibody; EBK antibody; EHK-3 antibody; EHK3 antibody; EK11 antibody; Embryonic brain kinase antibody; EPH homology kinase 3 antibody; EPH-like kinase 11 antibody; Epha7 antibody; EPHA7_HUMAN antibody; Ephrin receptor Eph A7 antibody; Ephrin type A receptor 7 antibody; Ephrin type-A receptor 7 antibody; hEK11 antibody; MDK 1 antibody; Receptor protein tyrosine kinase HEK 11 antibody; Tyrosine protein kinase receptor EHK 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ephrin type-A receptor 7 protein (28-182AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
  • 基因功能參考文獻:
    1. receptor phosphorylation of EphA7, at least in part, suppress prostate cancer tumor malignancy through targeting PI3K/Akt signaling pathways. PMID: 29022918
    2. these findings suggest that miR-448 functioned as a tumor suppressor gene in the development of osteosarcoma through targeting EPHA7. PMID: 28604772
    3. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness. PMID: 27566654
    4. Eph receptor A7 may have an important role in the pathogenesis of nonsmall cell lung cancer by regulating PTEN expression via thephosphatase and tensin homolog/AKT pathway. PMID: 26936314
    5. Depletion of EphA7 remarkably inhibited the proliferation and invasion of Hep-2 and AMC-HN-8 cells in comparison to control and EphA7 siRNA negative control (NC)-transfected cells. PMID: 25968442
    6. Authors observed that the extracellular region of the EphA7 receptor was critical for interacting with caspase-8, whereas the cytoplasmic region of EphA7 was not. PMID: 25855521
    7. miR-137 is able to directly bind to the EPHA7 3'UTR and negatively regulate the expression of EPHA7 in HUVECs. PMID: 24927112
    8. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. PMID: 21964981
    9. The expression of EphA7 and/or MTDH might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma. PMID: 21609571
    10. Overexpression of EphA7 and/or MTDH might indicate poor prognosis in squamous cell cancer of the tongue. PMID: 22246354
    11. EPHA7 acts as a tumor suppressor in vivo and is targeted by genomic deletions and differential epigenetic silencing in human lymphomas. PMID: 22036564
    12. EphA7 protein expression is significantly correlated with the biological behavior of primary hepatocellular carcinoma. PMID: 20302756
    13. analysis of the secreted form of EphA7 in lung cancer PMID: 20126984
    14. downregulation of an Eph family gene in a solid tumor via aberrant 5'CpG island methylation, providing evidence that EphA7 gene is involved in human colorectal carcinogenesis PMID: 16007213
    15. EphA7 expression in 52 gastric carcinoma was consistent with its transcript expression, with the protein being significantly overexpressed in younger patients (P = .016) and in patients with advanced tumors (P = .033) PMID: 17669470
    16. siRNA-mediated suppression of ALL1/AF4 in SEMK2 cells carrying the t(4;11) chromosome translocation resulted in down-regulation of EphA7 PMID: 17726105
    17. EphA7 protein may have a role in progression of glioblastoma multiforme PMID: 18366728
    18. epigenetic inactivation of EphA7 may be involved in prostate carcinogenesis PMID: 18821581

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 3390

    OMIM: 602190

    KEGG: hsa:2045

    STRING: 9606.ENSP00000358309

    UniGene: Hs.73962



主站蜘蛛池模板: 曰批免费视频播放免费| 成人免费的视频| 欧美一性一乱一交一视频| 日本中文字幕乱码aa高清电影| 玩50岁四川熟女大白屁股直播| 国产亚洲欧美在线专区| 国产精品186在线观看在线播放| 日日做夜狠狠爱欧美黑人| 少妇人妻综合久久中文| 小罗莉极品一线天在线| 蜜桃无码一区二区三区| 国产精品一区二区久久乐下载| 欧美成人高清视频a在线看| 亚洲欧美在线观看| 妺妺窝人体色www在线小说| 国产清纯在线一区二区www| 欧美大波少妇在厨房被| 国产午夜激无码av毛片不卡| 精品无码一区二区三区电影| 欧美处交wwwvideos另类| 亚洲免费观看视频| 成人性生交片无码免费看| 欧美大片18禁aaa免费视频| 精品国产乱码久久久久久夜深人妻 | 国产日韩精品欧美2020区| 日本一上一下爱爱免费| 男女性高爱潮免费观看| 久久久久成人精品无码| 久章草在线精品视频免费观看| av综合网男人的天堂| 国产精品一区二区久久不卡| 97久久香蕉国产线看观看| 国产精品国产三级国产an| 国产av一区二区精品久久凹凸| 精品日本一区二区三区在线观看| 人妻熟女 视频二区 视频一区| 东京一本一道一二三区| 午夜影视免费| 免费国产a国产片高清网站| 亚洲 日韩 国产 有码 不卡| 国产一区二区三区不卡av|