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  4. EPB41L2 Antibody

EPB41L2 Antibody

  • 中文名稱：
    EPB41L2兔多克隆抗體
  • 貨號：
    CSB-PA000768
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using 4.1G Polyclonal Antibody
    • Western Blot analysis of K562 cells using 4.1G Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    EPB41L2
  • 別名：
    4.1 G antibody; 4.1G antibody; AW555191 antibody; Band 4.1 like protein 2 antibody; Band 4.1-like protein 2 antibody; D10Ertd398e antibody; DKFZp781D1972 antibody; DKFZp781H1755 antibody; E41L2_HUMAN antibody; Epb41l2 antibody; Erythrocyte membrane protein band 4.1 like 2 antibody; Erythrocyte membrane protein band 4.1 like protein 2 antibody; Generally expressed protein 4.1 antibody; NBL2 antibody; OTTHUMP00000017197 antibody; OTTHUMP00000040262 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human 4.1G.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
  • 基因功能參考文獻：
    1. Ca(2+)/CaM binding to GHP, and more specifically to pepG, has profound effects on other functional domains of 4.1G PMID: 23354586
    2. 4.1G protein depresses PTH-related protein receptor-mediated Gs signaling pathway by suppression of adenylyl cyclase-mediated cAMP production. PMID: 23201780
    3. A phosphoserine-dependent tethering role for protein 4.1G in lipid rafts provides insight into the unique phosphoserine-based regulation of FcgammaRI receptor signaling. PMID: 22003208
    4. PTA-1(CD226 antigen) is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G and also can bind human discs large providing the structural basis for a regulated molecular adhesive complex PMID: 15138281
    5. An alternatively spliced 4.1G product is shown to be associated with increased Fc gamma RI binding in yeast two-hybrid assays, and to be selectively enriched in most immune cells at the transcript level. PMID: 18023480

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell membrane.
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3379

    OMIM: 603237

    KEGG: hsa:2037

    STRING: 9606.ENSP00000338481

    UniGene: Hs.486470



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