在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EN2 Antibody, FITC conjugated

  • 中文名稱:
    EN2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA007660LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) EN2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EN2
  • 別名:
    EN2 antibody; Homeobox protein engrailed-2 antibody; Homeobox protein en-2 antibody; Hu-En-2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Homeobox protein engrailed-2 protein (1-251AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. The EN2 transcription factor is a novel ovarian cancer biomarker. It demonstrates prognostic value, correlating with worse Overall Survival and Progression-free Survival. PMID: 30285763
    2. we confirmed that engrailed-2 is the target of hsa-miR-27b in human cytomegalovirus-infected glioma cells PMID: 28343438
    3. The critical role of miR212 in inhibiting prostate tumor growth was verified in xenograft models of prostate cancer. These findings highlighted the role of miR212 in PCa progression. More importantly, we speculate that EN-2 is a direct target gene of miR212. PMID: 28713997
    4. We identified a novel heterozygous missense variant (c.425C>G, p.Pro142Arg) in the Engrailed 2 (EN2) gene in two patients. The G variant has never been reported in public databases and was absent in 100 Thai patients with ASD and 435 Thai controls. A case-control study showed that the G allele of c.425C>G was significantly associated with ASD PMID: 27755371
    5. EN2 is negatively regulated by miR-605, and down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer (PCa) cells by up-regulating EN2, which leads to PCa development and progression PMID: 28943214
    6. Our data suggest that the functional interaction of miR-33a and EN-2 is involved in tumorigenesis of prostate cancer PMID: 27921232
    7. the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells. PMID: 26948025
    8. EN2 may be a candidate oncogene in bladder cancer by activating the PI3K/Akt pathway and inhibiting PTEN. PMID: 25812440
    9. Engrailed-2 (EN-2) is a developmentally regulated homeobox gene that is essential for Purkinje cell maturation and normal cerebellar development and patterning. PMID: 25290267
    10. The mean EN2 levels in prostate cancer patients were 3.76-fold higher than those in non-prostate patients after prostate massage. PMID: 25003607
    11. The exact role of EN2 expression in renal carcinoma carcinogenesis requires further investigation. PMID: 24532139
    12. En2 identified as a new regulator of T-cell differentiation whose disruption induces a malignant T-cell fate in chronic myelogenous leukemia progression. PMID: 24675889
    13. Two patients with underdeveloped arcuate fasciculus had novel, nonsynonymous variants in MID1 and EN2 genes regulating axon guidance pathway. PMID: 24321989
    14. EN2 levels are increased in affected individuals with an A-C/G-T genotype, supporting EN2 as an autism spectrum disorder susceptibility gene. PMID: 24520327
    15. urinary EN2 has the potential to be a more sensitive and specific protein biomarker for non-muscle-invasive bladder cancer than currently available tests. PMID: 23434148
    16. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals PMID: 23792811
    17. Normal EN-2 downregulation may not occur in some individuals with autism, such that the postnatal persistence of EN-2 overexpression may contribute to autism cerebellar abnormalities. PMID: 23423141
    18. The WNT2 gene and EN2 gene may act in concert to influence the language development in autism. PMID: 22522212
    19. findings show EN2 was expressed and secreted by prostate cancer (PC) cell lines and PC tissue but not by normal prostate tissue or stroma; presence of EN2 in urine was highly predictive of PC PMID: 21364037
    20. This study demonistrated that in Han chinese the association between the EN2 genetic polymorphism and autism. PMID: 20523082
    21. Positive genetic correlation of EN2 with autism in the Indian population. PMID: 20050924
    22. In human, failure to form a mesencephalon and metencephalon, with cerebellar hypoplasia, results drom a mutation or deletion in EN2(Engrailed-2) gene. PMID: 11815869
    23. EN2 exon 1 variant transmission disequilibrium test shows no association with autistic disorder nor association between language and stereotypic behaviour quantitative traits. PMID: 12525552
    24. An association between a cerebellar patterning gene and autism spectrum disorder suggests a role for EN2 as a susceptibility locus and supports a neurodevelopmental defect hypothesis in the etiology of autism. PMID: 15024396
    25. RNA interference studies suggest that EN2 expression is required for the maintenance of the transformed phenotype of a human breast tumor cell line PMID: 16007149
    26. Loss and gain of function experiments firmly establish that En1/2 is a true survival factor for dopaminergic neurons in vivo. PMID: 17267560
    27. Heterogeneous association between engrailed-2 and autism in the CPEA network PMID: 17948868
    28. a preferential transmission of the rs3824068 A-allele to AUTISM affected offspring PMID: 17948901
    29. Engrailed 2 gene is associated with autistic disorder in Chinese children. PMID: 18424904
    30. The majority of regulated genes were down-regulated in engrailed-2 cerebella from transgenic mice, consistent with the known repressive function of Engrailed-2. PMID: 18562208
    31. variations of the engrailed-2 gene are implicated in the development of young-onset Parkinson's disease PMID: 19270442
    32. The data of this study indicated that the A-C haplotype is functional and, together with the association and LD mapping results, supports EN2 as a likely autism susceptibility gene and the A-C haplotype as a possible risk allele. PMID: 19615670

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Genetic variations in EN2 may be associated with susceptibility to autism.
  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    Engrailed homeobox family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3343

    OMIM: 131310

    KEGG: hsa:2020

    STRING: 9606.ENSP00000297375

    UniGene: Hs.134989



主站蜘蛛池模板: 国产一区二区三区四区五区vm| 亚洲国产人在线播放首页| 人妻人人做人碰人人添| 欧美成人看片一区二区三区尤物| 免费午夜无码片在线观看影院| 极品少妇扒开粉嫩小泬视频| 日本嫩交12一16xxx视频| 又粗又大内射免费视频小说| 西西人体大胆午夜啪啪| 丁香五月综合久久激情| 好想被狂躁无码视频在线观看| 久久不见久久见免费影院3| 男女超爽视频免费播放| 国产在线拍揄自揄视频导航| 国产成人一区二区不卡免费视频| 色综合中文综合网| 亚洲精品无码久久千人斩| 无码日韩人妻av一区免费| 欧美日韩在线视频一区| 无码人妻精品一区二区蜜桃网站| 久久亚洲精品无码爱剪辑| 国产 制服丝袜 动漫在线| 天天做天天爱夜夜夜爽毛片| 偷偷做久久久久网站| 国产亚洲日本精品无码| 色婷婷综合缴情综免费观看| 国产精品一卡二卡三卡| 337p亚洲日本中国大胆69| 亚洲成av人片天堂网| 推油少妇久久99久久99久久| 无码人妻精品中文字幕不卡| 国产成人综合久久免费| 亚洲人成电影网站色www两男一女| 真人做作爱视频| 国产男女免费完整视频在线| 亚洲国产精品第一区二区| 日韩成人无码| 亚洲成亚洲成网| 亚洲国产精品成人午夜在线观看| 丰满大爆乳波霸奶| 精品国产免费人成电影在线看|