在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EMP2 Antibody, HRP conjugated

  • 中文名稱:
    EMP2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA007649LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EMP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EMP2
  • 別名:
    EMP2; XMP; Epithelial membrane protein 2; EMP-2; Protein XMP
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Epithelial membrane protein 2 protein (22-66AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity. Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion. Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation. Regulates cell migration and cell contraction through PTK2 and SRC activation. Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2. Positively regulates cell proliferation. Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway. Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3. May play a role in glomerular filtration.
  • 基因功能參考文獻:
    1. It is a biomarker in gliomas and may have use as a molecular target for the diagnosis and treatment of gliomas. PMID: 28887715
    2. High EMP2 expression is associated with endometrial cancer. PMID: 28604744
    3. Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1alpha expression. The results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans, and suggest that it may be a new biomarker for placental insufficiency. PMID: 28295343
    4. All studied ERMs and PVR membranes express EMP2. Levels of EMP2 trended higher in all PVR subgroups than in ERMs, especially in inflammatory and traumatic PVR. PMID: 27294805
    5. a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population. PMID: 27530449
    6. These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma. PMID: 28347228
    7. Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
    8. EMP2 plays a tumor suppressor role by inducing G2/M cell cycle arrest, suppressing cell viability, proliferation, colony formation/ anchorage-independent cell growth via regulation of G2/M checkpoints in distinct-derived cell lines. PMID: 25940704
    9. Loss of EMP2 is associated with nasopharyngeal carcinoma. PMID: 25684502
    10. the role of EMP2 in the pathogenesis of GBM a PMID: 24644285
    11. We showed that knockdown of EMP2 in podocytes and endothelial cells resulted in an increased amount of CAVEOLIN-1 and decreased cell proliferation, so EMP2 mutations causes a recessive Mendelian form of steroid-sensitive nephrotic syndrome. PMID: 24814193
    12. EMP2 was identified as a tumor-suppressor gene in urinary tract urothelial carcinoma. PMID: 23838430
    13. support the role of EMP2 in the control of the tumor microenvironment and confirm the cytotoxic effects observed by EMP2 treatment in vivo PMID: 23334331
    14. Manipulation of EMP2 levels in endometrial cancer cells regulates the phosphorylation of FAK and Src, and promotes their distribution into lipid raft domains. PMID: 21637765
    15. EMP2 is expressed in the majority of ovarian tumors and may be a feasible target in vivo. PMID: 20670949
    16. evaluation as candidate gene for Charcot-Marie-Tooth disease type 1C on chromosome 16p PMID: 11713717
    17. This protein is expressed in discrete anatomical regions of the eye. PMID: 12710941
    18. EMP2 induces alphavbeta3 surface expression. PMID: 16216233
    19. These findings identify EMP2 as a candidate host protein involved in infection of Chlamydia muridarum. [EMP-2] PMID: 17544801
    20. EMP2 regulates caveolin-1 transcription and more substantially its protein levels. PMID: 17609206
    21. Targeting of EMP2 to specific locations under the influence of these steroid hormones may be important for integrating the molecular responses required for implantation competence. PMID: 18400107
    22. EMP2 may be a potential pharmacologic target for human endometrial cancer. PMID: 19010852

    顯示更多

    收起更多

  • 相關疾病:
    Nephrotic syndrome 10 (NPHS10)
  • 亞細胞定位:
    Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus.
  • 蛋白家族:
    PMP-22/EMP/MP20 family
  • 組織特異性:
    Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level).
  • 數據庫鏈接:

    HGNC: 3334

    OMIM: 602334

    KEGG: hsa:2013

    STRING: 9606.ENSP00000352540

    UniGene: Hs.531561



主站蜘蛛池模板: 亚洲已满18点击进入在线观看| 女人的精水喷出来视频| 国产熟妇高潮呻吟喷水| 国产精品国产三级国产剧情| 久久综合久中文字幕青草| 亚洲精品美女久久久久久久| 日韩精品a片一区二区三区妖精| 国产午夜福利片| 岛国4k人妻一区二区三区| 先锋影音av资源站av| 蜜臀avwww国产天堂| 五月丁香六月综合缴清无码| 亚洲精品美女久久久久99| 综合久久—本道中文字幕| 无码国产成人午夜在线观看| 国产精自产拍久久久久久蜜| 波多野结衣av在线无码中文18| 日韩高清在线亚洲专区小说| 中文字幕av一区| 色婷婷久久综合中文久久蜜桃av| 丝袜无码专区人妻视频| 亚洲狠狠爱综合影院网页| 午夜福利理论片高清在线观看| 99国产精品自在自在久久| 亚洲性夜夜综合久久7777| 色琪琪av中文字幕一区二区| 国产精品国产三级国产专区53| 51妺嘿嘿午夜福利| 少妇性荡欲视频| 中文字幕无线码中文字幕免费| 亚洲国产一区二区三区| 国产在线视频天天综合网| 午夜精品射精入后重之免费观看| 中国女人做爰视频| 人妻少妇久久中文字幕456| 久热中文字幕无码视频| 亚洲色成人网站www永久| 亚洲无人区码一码二码三码的含义| 国产成人精品午夜视频| 欧美性受xxxx白人性爽| 丰满人妻一区二区三区视频53|