在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EMP2 Antibody, Biotin conjugated

  • 中文名稱:
    EMP2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA007649LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EMP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EMP2
  • 別名:
    EMP2; XMP; Epithelial membrane protein 2; EMP-2; Protein XMP
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Epithelial membrane protein 2 protein (22-66AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity. Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion. Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation. Regulates cell migration and cell contraction through PTK2 and SRC activation. Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2. Positively regulates cell proliferation. Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway. Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3. May play a role in glomerular filtration.
  • 基因功能參考文獻:
    1. It is a biomarker in gliomas and may have use as a molecular target for the diagnosis and treatment of gliomas. PMID: 28887715
    2. High EMP2 expression is associated with endometrial cancer. PMID: 28604744
    3. Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1alpha expression. The results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans, and suggest that it may be a new biomarker for placental insufficiency. PMID: 28295343
    4. All studied ERMs and PVR membranes express EMP2. Levels of EMP2 trended higher in all PVR subgroups than in ERMs, especially in inflammatory and traumatic PVR. PMID: 27294805
    5. a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population. PMID: 27530449
    6. These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma. PMID: 28347228
    7. Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
    8. EMP2 plays a tumor suppressor role by inducing G2/M cell cycle arrest, suppressing cell viability, proliferation, colony formation/ anchorage-independent cell growth via regulation of G2/M checkpoints in distinct-derived cell lines. PMID: 25940704
    9. Loss of EMP2 is associated with nasopharyngeal carcinoma. PMID: 25684502
    10. the role of EMP2 in the pathogenesis of GBM a PMID: 24644285
    11. We showed that knockdown of EMP2 in podocytes and endothelial cells resulted in an increased amount of CAVEOLIN-1 and decreased cell proliferation, so EMP2 mutations causes a recessive Mendelian form of steroid-sensitive nephrotic syndrome. PMID: 24814193
    12. EMP2 was identified as a tumor-suppressor gene in urinary tract urothelial carcinoma. PMID: 23838430
    13. support the role of EMP2 in the control of the tumor microenvironment and confirm the cytotoxic effects observed by EMP2 treatment in vivo PMID: 23334331
    14. Manipulation of EMP2 levels in endometrial cancer cells regulates the phosphorylation of FAK and Src, and promotes their distribution into lipid raft domains. PMID: 21637765
    15. EMP2 is expressed in the majority of ovarian tumors and may be a feasible target in vivo. PMID: 20670949
    16. evaluation as candidate gene for Charcot-Marie-Tooth disease type 1C on chromosome 16p PMID: 11713717
    17. This protein is expressed in discrete anatomical regions of the eye. PMID: 12710941
    18. EMP2 induces alphavbeta3 surface expression. PMID: 16216233
    19. These findings identify EMP2 as a candidate host protein involved in infection of Chlamydia muridarum. [EMP-2] PMID: 17544801
    20. EMP2 regulates caveolin-1 transcription and more substantially its protein levels. PMID: 17609206
    21. Targeting of EMP2 to specific locations under the influence of these steroid hormones may be important for integrating the molecular responses required for implantation competence. PMID: 18400107
    22. EMP2 may be a potential pharmacologic target for human endometrial cancer. PMID: 19010852

    顯示更多

    收起更多

  • 相關疾病:
    Nephrotic syndrome 10 (NPHS10)
  • 亞細胞定位:
    Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus.
  • 蛋白家族:
    PMP-22/EMP/MP20 family
  • 組織特異性:
    Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level).
  • 數據庫鏈接:

    HGNC: 3334

    OMIM: 602334

    KEGG: hsa:2013

    STRING: 9606.ENSP00000352540

    UniGene: Hs.531561



主站蜘蛛池模板: 中文字幕av无码一二三区电影| 色噜噜亚洲男人的天堂| 国产白嫩漂亮美女在线观看| 亚洲性色成人av| 熟女乱亚洲图| 美女视频黄是免费| 久久人人爽人人爽人人爽| 四虎亚洲精品无码| 日韩亚洲国产中文永久| 中文字幕无码乱码人妻系列蜜桃 | 最新亚洲春色av无码专区| 一本色道无码道在线观看| 99久久国产综合精品女图图等你| 亚洲成a人片在线观看你懂的| 50路60路老熟妇啪啪| 亚洲国产高清av网站| 亚洲国产精品无码久久一区二区| 中国少妇xxxx做受| 成人国产亚洲精品a区天堂| 男人撕开奶罩揉吮奶头视频| 亚洲中文字幕av每天更新| 韩国精品视频一区二区在线播放| 亚洲熟女www一区二区三区| 久久久久久久女国产乱让韩| 日日摸天天摸人人看| 免费国产在线精品一区二区三区| 国产又黄又大又粗的视频| 婷婷久久综合九色综合| 97性无码区免费| 国产精品无码午夜免费影院| 亚洲欧美日韩在线不卡| 免费午夜无码片在线观看影院 | 18禁女裸乳扒开免费视频| 国模国产精品嫩模大尺度视频| 97精品国产一区二区三区四区| 亚洲综合国产成人丁香五月激情| 真实国产乱子伦对白视频不卡| 久久综合久久爱久久综合伊人| 国产热re99久久6国产精品首页| 扒开双腿吃奶呻吟做受视频| 国产成人片无码免费视频|