在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EIF4A3 Antibody, Biotin conjugated

  • 中文名稱:
    EIF4A3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA007553LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) EIF4A3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EIF4A3
  • 別名:
    ATP-dependent RNA helicase DDX48 antibody; ATP-dependent RNA helicase eIF4A-3 antibody; DDX48 antibody; DEAD box protein 48 antibody; eIF-4A-III antibody; eIF4A-III antibody; EIF4A3 antibody; eIF4AIII antibody; Eukaryotic initiation factor 4A-III antibody; Eukaryotic initiation factor 4A-like NUK-34 antibody; Eukaryotic translation initiation factor 4A isoform 3 antibody; hNMP 265 antibody; IF4A3_HUMAN antibody; NMP 265 antibody; NMP265 antibody; Nuclear matrix protein 265 antibody; NUK34 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Eukaryotic initiation factor 4A-III protein (6-166AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development.
  • 基因功能參考文獻(xiàn):
    1. FAL1 may work as a ceRNA to modulate AKT1 expression via competitively binding to miR-637 in HSCR. PMID: 30062828
    2. we firstly report that the lncRNA H19 recruits eIF4A3 and promotes the colorectal cancer cell proliferation PMID: 26989025
    3. High EIF4A expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas. PMID: 26951381
    4. MYC, DUX4, and EIF4A3 might contribute to facioscapulohumeral dystrophy pathophysiology PMID: 28273136
    5. Host eIF4AIII RNA helicase is required for efficient human cytomegalovirus replication. PMID: 26773380
    6. EIF4A3 is a gene involved in RNA metabolism, plays a role in mandible, laryngeal, and limb morphogenesis. Richieri-Costa-Pereira syndrome is caused by mutations in EIF4A3. PMID: 24360810
    7. The binding mode of CWC22 to eIF4AIII reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins. PMID: 24218557
    8. CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly PMID: 22961380
    9. demonstrate direct physical interactions between yeast Sgd1p and Fal1p, and between their human orthologs (NOM1 and eIF4AIII) in vitro and in vivo, identifying human NOM1 as a missing eIF4G-like interacting partner of eIF4AIII PMID: 21576267
    10. identification of eIF4AIII and Barentsz as components of a conserved protein complex that is essential for mRNA localization in flies and nonsense-mediated mRNA decay in mammals PMID: 14973490
    11. eIF4AIII represents a new functional class of DExH/D box proteins that act as RNA clamps or 'place holders' for the sequence-independent attachment of additional factors to RNAs. PMID: 15034551
    12. detection of autoantibodies to DDX48 may have clinical utility for the improved diagnosis of pancreatic cancer PMID: 15796914
    13. The stable association of multiprotein exon junction complex core with RNA is maintained by inhibition of eIF4AIII ATPase activity by MAGOH-Y14. PMID: 16170325
    14. crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic PMID: 16931718
    15. Although it is dispensable for pre-mRNA splicing in vitro, eIF4A3 is required for splicing-dependent loading of the Y14-Magoh core heterodimer onto mRNA. PMID: 17606899
    16. Data show that eIF4AIII, a core exon junction complex (EJC) component loaded onto mRNAs by pre-mRNA splicing, is associated with neuronal mRNA granules and dendritic mRNAs. PMID: 17632064
    17. The nonsense-mediated-decay mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. PMID: 18427545
    18. NMP 265, a common part of the nuclear matrix, is located in the nucleus via an N-terminal amino acid sequence. PMID: 10623621

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Richieri-Costa-Pereira syndrome (RCPS)
  • 亞細(xì)胞定位:
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族:
    DEAD box helicase family, eIF4A subfamily
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18683

    OMIM: 268305

    KEGG: hsa:9775

    STRING: 9606.ENSP00000269349

    UniGene: Hs.389649



主站蜘蛛池模板: 狠狠躁夜夜躁人人躁婷婷| 美女mm131爽爽爽作爱| 国产精品高清不卡在线播放| 亚洲高清专区日韩精品| 日韩av无码一区二区三区无码| 天天影视性色香欲综合网| 精品无人区麻豆乱码1区2区| av色综合久久天堂av色综合| 日本欧美一区二区三区乱码| 成·人免费午夜视频香蕉| а天堂中文在线官网在线| 久久久久成人精品无码| 国产情侣真实露脸在线| 色欲aⅴ亚洲情无码av蜜桃| 超碰cao已满18进入离开官网| av天堂久久精品影音先锋| 免费国产高清在线精品一区| 熟妇人妻一区二区三区四区| 免费超爽大片黄| 精品久久一区二区乱码| 久久久亚洲欧洲日产国码二区 | 亚洲 欧美日韩 综合 国产| 欧美性生交xxxxx久久久| 国产97公开成人免费视频在线观看| 撕开奶罩揉吃奶高潮av在线观看| 少妇与子乱毛片| 国产精品99久久精品爆乳| 玩弄人妻少妇500系列视频| 奇米四色7777中文字幕| 国产高跟黑色丝袜在线| 毛片内射久久久一区| 熟女人妻一区二区三区免费看| 中文中幕a在线| 风韵犹存丰满大屁股熟妇视频| 亚洲欲色欲色xxxxx在线| 成人无码视频| 东北女人毛多水多牲交视频| 亚洲国产成在人网站天堂| 亚洲色无码中文字幕手机在线| 人人妻人人澡av| 久99久无码精品视频免费播放|