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  4. EDEM2 Antibody, Biotin conjugated

EDEM2 Antibody, Biotin conjugated

  • 中文名稱：
    EDEM2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA861146LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EDEM2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    bA4204.1 antibody; C20orf31 antibody; C20orf49 antibody; EDEM 2 antibody; EDEM2 antibody; EDEM2_HUMAN antibody; ER degradation enhancer mannosidase alpha like 2 antibody; ER degradation enhancing alpha mannosidase like 2 antibody; ER degradation enhancing alpha mannosidase like protein 2 antibody; ER degradation enhancing mannosidase like protein 2 antibody; ER degradation-enhancing alpha-mannosidase-like 2 antibody; FLJ10783 antibody; UNQ573/PRO1135 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 2 protein (22-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.
  • 基因功能參考文獻：
    1. EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog PMID: 24910992
    2. Glycoproteins mannose trimming from Man9GlcNAc2 to Man8GlcNAc2 is conducted mainly by EDEM2. PMID: 25092655
    3. Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in endoplasmic reticulum associated degradation. PMID: 15537790
    4. EDEM2 regulates endoplasmic reticulum-associated glycoprotein degradation PMID: 15579471
    5. Degrades misfolded alpha1-antitrypsin in the ER. PMID: 15537790

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  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Glycosyl hydrolase 47 family
  • 組織特異性：
    Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 15877

    OMIM: 610302

    KEGG: hsa:55741

    STRING: 9606.ENSP00000363616

    UniGene: Hs.720177



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