在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EDAR Antibody

  • 中文名稱:
    EDAR兔多克隆抗體
  • 貨號:
    CSB-PA083210
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA083210(EDAR Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA083210(EDAR Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 2 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    EDAR
  • 別名:
    Anhidrotic ectodysplasin receptor 1 antibody; DL antibody; Downless (mouse) homolog antibody; Downless homolog antibody; Downless mouse homolog of antibody; ECTD10A antibody; ECTD10B antibody; Ectodermal dysplasia receptor antibody; Ectodysplasin 1 anhidrotic receptor antibody; Ectodysplasin A receptor antibody; Ectodysplasin A1 isoform receptor antibody; Ectodysplasin-A receptor antibody; ED 1R antibody; ED 3 antibody; ED 5 antibody; ED1R antibody; ED3 antibody; ED5 antibody; EDA 1R antibody; EDA 3 antibody; EDA A1 receptor antibody; EDA A1R antibody; EDA-A1 receptor antibody; EDA1R antibody; EDA3 antibody; Edar antibody; EDAR_HUMAN antibody; HRM1 antibody; Tumor necrosis factor receptor superfamily member EDAR antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human EDAR
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:35-1:150
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
  • 基因功能參考文獻:
    1. 10 and five quantitative trait-associated mutations for oxygen saturation (SaO2) and blood platelet count, respectively, are identified at the Edar Receptor (EDAR) locus. rs10865026 and rs3749110 (associated with SaO2 and platelet count, respectively) are functional candidate targets. EDAR has undergone natural selection in recent human history and EDAR variants has an important role in Tibetan high-altitude adaptations. PMID: 28795375
    2. Results suggested that SNPs in EDAR could be a pathogenic factor for non-syndromic tooth agenesis. Furthermore, EDAR can be regarded as a marker gene for the risk of tooth agenesis. PMID: 28808699
    3. To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575). PMID: 27487801
    4. Partial least square path model confirms EDARV370A systematically affect these weakly related ectodermal-derived characteristics, suggesting the pleiotropic effect of EDARV370A mainly plays roles in early embryo development PMID: 26603699
    5. Four traits of ear pinna anatomic variation are associated with a functional variant in the EDAR gene, a key regulator of embryonic skin appendage development. PMID: 26105758
    6. we have identi fi ed a novel frameshift mutation in an Italian family with autosomal dominant hypohidrotic ectodermal dysplasia resulting in a mild clinical phenotype. PMID: 24641098
    7. Individuals with a c.1072C > T mutation in the EDAR-gene displayed more hair shaft deformations confirming the role of EDAR for human hair follicle development and postnatal hair follicle cycling. PMID: 26336973
    8. Confirmed that EDARV370A, a variant that first originated in East Asia about 30000 years ago, played an important role in incisor shoveling in East Asia. This suggests that incisor shoveling in modern East Asians appeared after the late Pleistocene. PMID: 24752358
    9. Individuals with a c.1072C > T mutation in the EDAR-gene displayed a typical pattern of congenitally missing teeth in the frontal area with functional consequences. PMID: 24884697
    10. Using whole-exome sequencing we describe a novel homozygous missense mutation in EDAR causing autosomal recessive HED associated with palmoplantar hyperkeratosis and the absence of breasts. PMID: 23210707
    11. Study generated a knockin mouse model and found that, as in humans, hair thickness is increased in EDAR370A mice; new biological targets affected by the mutation were identified, including mammary and eccrine glands. Building on these results EDAR370A was found to be associated with an increased number of active eccrine glands in the Han Chinese. PMID: 23415220
    12. This is the first report of a founder EDAR mutation and of a significantly high frequency of autosomal recessive HED. PMID: 22032522
    13. WNT10A and EDAR were each responsible for 16% of hypohidrotic/anhidrotic ectodermal dysplasia cases. PMID: 20979233
    14. screening of all the 12 exons and splice junctions of gene EDAR revealed a novel missense mutation (c.1163T>C; p.Ile388Thr) in family A and a novel insertion mutation (c.1014insA; p.V339SfsX6) in family B. PMID: 21771270
    15. Data show that 25 different mutations on EDA and EDAR genes were detected in HED patients. PMID: 20236127
    16. a novel compound heterozygous mutation [c.52-2A>G; c.212G>A (p.Cys71Tyr)]; significance of the EDAR signalling pathway in the ectodermal morphogenesis. PMID: 20033817
    17. DNA sequence analysis of EDAR gene in a Pakistani family, demonstrating autosomal recessive form of hypohidrotic ectodermal dysplasia, identified a novel homozygous mutation affecting splice donor site of exon 5 [IVS5+1G > or = C] of the gene PMID: 20199431
    18. isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR PMID: 16423472
    19. EDAR mutations account for one-quarter of non-ED1-related hypohidrotic ectodermal dyspl PMID: 16435307
    20. novel deletion mutation in a Pakistani family with autosomal recessive hypohidrotic ectodermal dysplasia PMID: 17501952
    21. study reports the molecular analyses of four patients from India with hypohidrotic ectodermal dysplasia, three who harbour novel mutations, two in the EDA gene and one in the EDAR gene PMID: 17970812
    22. EDAR is a major genetic determinant of Asian hair thickness and the 1540C allele spread through Asian populations due to recent positive selection PMID: 18065779
    23. Patients with homozygous or compound heterozygous mutations in the EDAR gene have a more severe phenotype of hypohidrotic ectodermal dysplasia than those with a heterozygous missense, nonsense or frame-shift mutation PMID: 18231121
    24. Study shows that the derived EDAR370A common in East Asia has a more potent signaling output than the ancestral EDAR370 V; shows that elevation of Edar activity in transgenic mice converts their hair phenotype to the typical East Asian morphology. PMID: 18561327
    25. EDAR is the genetic determinant of hair thickness as well as a strong contributor to hair fiber thickness variation among Asian populations. PMID: 18704500
    26. results expand the allelic series for mutations underlying hypohidrotic ectodermal dysplasia PMID: 19438931
    27. Recurrent mutations in functionally-related EDA and EDAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohidrotic ectodermal dysplasia. PMID: 19551394
    28. an EDAR variant is a genetic determinant of shovel-shaped incisors PMID: 19804850

    顯示更多

    收起更多

  • 相關疾病:
    Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant (ECTD10A); Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD10B)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
  • 數據庫鏈接:

    HGNC: 2895

    OMIM: 129490

    KEGG: hsa:10913

    STRING: 9606.ENSP00000258443

    UniGene: Hs.171971



主站蜘蛛池模板: 国产精品无码永久免费不卡 | 亚洲国产成人精品无码区99 | 国产剧情国产精品一区| 国产亚洲精品ae86| 激情内射人妻1区2区3区| 亚洲精品国产福利一区二区| 久久午夜色播影院| 亚洲国产精品无码中文字2022| 国产精品天干天干| 啦啦啦www播放日本观看| 日本肉体xxxx裸体137大胆| 久久精品人妻无码一区二区三区v 国产薄丝脚交视频在线观看 | 亚洲va中文在线播放| 老熟妇乱子伦牲交视频| 西西人体www大胆高清| 久久国产主播福利在线| 亚洲精品四区麻豆文化传媒| 欧美午夜刺激影院| 国产97在线 | 中文| 国产蜜芽尤物在线一区| 色偷偷久久一区二区三区| 66亚洲一卡2卡新区成片发布| √最新版天堂资源网在线| 国产一卡三卡四卡无卡精品| 色五月丁香五月综合五月| 又大又硬又爽免费视频| 久久久受www免费人成| 欧美性性性性o00xx| 久久www免费人成_看片中文| 久久精品一区二区三区中文字幕| 99久久久无码国产精品古装| 国产农村黄aaaaa特黄av毛片| 国产精品美女久久久久av超清| 色妞色视频一区二区三区四区| 国产一区二区三区精品av| 亚洲欧洲日韩综合久久| 精品日本一区二区三区在线观看| 亚洲精品尤物av在线观看不卡| 精品综合久久久久久97| 一本色道久久综合亚洲精品| 欧美三级不卡在线播放|