在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EDAR Antibody, Biotin conjugated

  • 中文名稱:
    EDAR兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA892357LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EDAR Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EDAR
  • 別名:
    Anhidrotic ectodysplasin receptor 1 antibody; DL antibody; Downless (mouse) homolog antibody; Downless homolog antibody; Downless mouse homolog of antibody; ECTD10A antibody; ECTD10B antibody; Ectodermal dysplasia receptor antibody; Ectodysplasin 1 anhidrotic receptor antibody; Ectodysplasin A receptor antibody; Ectodysplasin A1 isoform receptor antibody; Ectodysplasin-A receptor antibody; ED 1R antibody; ED 3 antibody; ED 5 antibody; ED1R antibody; ED3 antibody; ED5 antibody; EDA 1R antibody; EDA 3 antibody; EDA A1 receptor antibody; EDA A1R antibody; EDA-A1 receptor antibody; EDA1R antibody; EDA3 antibody; Edar antibody; EDAR_HUMAN antibody; HRM1 antibody; Tumor necrosis factor receptor superfamily member EDAR antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tumor necrosis factor receptor superfamily member EDAR protein (27-170AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
  • 基因功能參考文獻:
    1. 10 and five quantitative trait-associated mutations for oxygen saturation (SaO2) and blood platelet count, respectively, are identified at the Edar Receptor (EDAR) locus. rs10865026 and rs3749110 (associated with SaO2 and platelet count, respectively) are functional candidate targets. EDAR has undergone natural selection in recent human history and EDAR variants has an important role in Tibetan high-altitude adaptations. PMID: 28795375
    2. Results suggested that SNPs in EDAR could be a pathogenic factor for non-syndromic tooth agenesis. Furthermore, EDAR can be regarded as a marker gene for the risk of tooth agenesis. PMID: 28808699
    3. To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575). PMID: 27487801
    4. Partial least square path model confirms EDARV370A systematically affect these weakly related ectodermal-derived characteristics, suggesting the pleiotropic effect of EDARV370A mainly plays roles in early embryo development PMID: 26603699
    5. Four traits of ear pinna anatomic variation are associated with a functional variant in the EDAR gene, a key regulator of embryonic skin appendage development. PMID: 26105758
    6. we have identi fi ed a novel frameshift mutation in an Italian family with autosomal dominant hypohidrotic ectodermal dysplasia resulting in a mild clinical phenotype. PMID: 24641098
    7. Individuals with a c.1072C > T mutation in the EDAR-gene displayed more hair shaft deformations confirming the role of EDAR for human hair follicle development and postnatal hair follicle cycling. PMID: 26336973
    8. Confirmed that EDARV370A, a variant that first originated in East Asia about 30000 years ago, played an important role in incisor shoveling in East Asia. This suggests that incisor shoveling in modern East Asians appeared after the late Pleistocene. PMID: 24752358
    9. Individuals with a c.1072C > T mutation in the EDAR-gene displayed a typical pattern of congenitally missing teeth in the frontal area with functional consequences. PMID: 24884697
    10. Using whole-exome sequencing we describe a novel homozygous missense mutation in EDAR causing autosomal recessive HED associated with palmoplantar hyperkeratosis and the absence of breasts. PMID: 23210707
    11. Study generated a knockin mouse model and found that, as in humans, hair thickness is increased in EDAR370A mice; new biological targets affected by the mutation were identified, including mammary and eccrine glands. Building on these results EDAR370A was found to be associated with an increased number of active eccrine glands in the Han Chinese. PMID: 23415220
    12. This is the first report of a founder EDAR mutation and of a significantly high frequency of autosomal recessive HED. PMID: 22032522
    13. WNT10A and EDAR were each responsible for 16% of hypohidrotic/anhidrotic ectodermal dysplasia cases. PMID: 20979233
    14. screening of all the 12 exons and splice junctions of gene EDAR revealed a novel missense mutation (c.1163T>C; p.Ile388Thr) in family A and a novel insertion mutation (c.1014insA; p.V339SfsX6) in family B. PMID: 21771270
    15. Data show that 25 different mutations on EDA and EDAR genes were detected in HED patients. PMID: 20236127
    16. a novel compound heterozygous mutation [c.52-2A>G; c.212G>A (p.Cys71Tyr)]; significance of the EDAR signalling pathway in the ectodermal morphogenesis. PMID: 20033817
    17. DNA sequence analysis of EDAR gene in a Pakistani family, demonstrating autosomal recessive form of hypohidrotic ectodermal dysplasia, identified a novel homozygous mutation affecting splice donor site of exon 5 [IVS5+1G > or = C] of the gene PMID: 20199431
    18. isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR PMID: 16423472
    19. EDAR mutations account for one-quarter of non-ED1-related hypohidrotic ectodermal dyspl PMID: 16435307
    20. novel deletion mutation in a Pakistani family with autosomal recessive hypohidrotic ectodermal dysplasia PMID: 17501952
    21. study reports the molecular analyses of four patients from India with hypohidrotic ectodermal dysplasia, three who harbour novel mutations, two in the EDA gene and one in the EDAR gene PMID: 17970812
    22. EDAR is a major genetic determinant of Asian hair thickness and the 1540C allele spread through Asian populations due to recent positive selection PMID: 18065779
    23. Patients with homozygous or compound heterozygous mutations in the EDAR gene have a more severe phenotype of hypohidrotic ectodermal dysplasia than those with a heterozygous missense, nonsense or frame-shift mutation PMID: 18231121
    24. Study shows that the derived EDAR370A common in East Asia has a more potent signaling output than the ancestral EDAR370 V; shows that elevation of Edar activity in transgenic mice converts their hair phenotype to the typical East Asian morphology. PMID: 18561327
    25. EDAR is the genetic determinant of hair thickness as well as a strong contributor to hair fiber thickness variation among Asian populations. PMID: 18704500
    26. results expand the allelic series for mutations underlying hypohidrotic ectodermal dysplasia PMID: 19438931
    27. Recurrent mutations in functionally-related EDA and EDAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohidrotic ectodermal dysplasia. PMID: 19551394
    28. an EDAR variant is a genetic determinant of shovel-shaped incisors PMID: 19804850

    顯示更多

    收起更多

  • 相關疾病:
    Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant (ECTD10A); Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD10B)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
  • 數據庫鏈接:

    HGNC: 2895

    OMIM: 129490

    KEGG: hsa:10913

    STRING: 9606.ENSP00000258443

    UniGene: Hs.171971



主站蜘蛛池模板: 尹人香蕉久久99天天拍欧美p7| 99国产精品人妻噜啊噜| аⅴ资源中文在线天堂| 精品少妇人妻av免费久久久| 国产真实乱对白精彩| 免费全部高h视频无码| 中文国产成人精品久久久| 亚洲精品一卡2卡三卡4卡 | 国产精品无码久久久久成人影院| 中文日韩亚洲欧美制服 | 亚洲高清无在码在线电影不卡| 中字幕视频在线永久在线| 少妇无码av无码专线区大牛影院| 天天综合爱天天综合色| 国产97色在线 | 亚洲| 麻豆tv入口在线看| 国产高清在线精品一区小说| 亚洲精品gv天堂无码男同| 精品亚洲麻豆1区2区3区| 亚洲精品一区中文字幕乱码| 欧美一道本一区二区三区| 天天鲁在视频在线观看| 在线欧美中文字幕农村电影| 老熟妇高潮喷了╳╳╳| 日本中文一二区有码在线| 国产真实露脸乱子伦| 里番本子纯肉侵犯肉全彩无码| 极品嫩模高潮叫床| 秋霞最新高清无码鲁丝片| 亚洲精品人成网线在播放va | 天堂一区人妻无码| 女同免费毛片在线播放| 男男又爽又黄又无遮挡网站| 激情五月综合色婷婷一区二区| 亚洲精品美女久久久久99| 先锋影音av资源站av| 人妻少妇乱子伦精品无码专区电影 | 国产午夜不卡片免费视频| 久久久久久亚洲精品不卡| 国产亚洲色婷婷久久99精品| 亚洲欲色欲色xxxxx在线观看|