在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

E2F6 Antibody

  • 中文名稱:
    E2F6兔多克隆抗體
  • 貨號:
    CSB-PA007347GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    E2F6
  • 別名:
    E2F 6 antibody; E2F binding site modulating activity protein antibody; E2F transcription factor 6 antibody; E2F transcription factor 6 isoform 1 antibody; E2F-6 antibody; E2F6 antibody; E2F6_HUMAN antibody; EMA antibody; MGC111545 antibody; Transcription factor E2F6 antibody
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human E2F6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
  • 基因功能參考文獻:
    1. This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype. PMID: 27909884
    2. After replication stress, the checkpoint kinase Chk1 phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F-dependent transcription, which mediates cell survival by preventing DNA damage and cell death PMID: 23954429
    3. findings indicate an inhibitory role of E2F6 in the regulation of IL-13 and allergy PMID: 22981205
    4. E2F6 may recruit BRG1 in transcriptional regulation of genes important for G1/S phase transition of the cell cycle. PMID: 23082233
    5. data suggest that E2F- and Myc-responsive genes are coregulated by E2F6 complex in quiescent cells PMID: 12004135
    6. results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters PMID: 12909625
    7. contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins PMID: 15081404
    8. E2F6 does not contain the domains required for modulation of squamous differentiation PMID: 15474455
    9. showed that E2F6, DP1, EPC1, EZH2, and Sin3B co-elute, suggesting the identification of a novel E2F6 complex that exists in vivo in both normal and transformed human cell lines PMID: 15536069
    10. functions as a repressor of E2F-dependent transcription during S phase PMID: 15574595
    11. PHC3 and E2F6 showed nuclear colocalization in a punctate pattern which was not seen in proliferating cells suggesting that PHC3 may be part of an E2F6-polycomb complex that has been shown to occupy and silence target promoters in G(0) PMID: 17001316
    12. E2F-6 inhibited Apaf-1 upregulation by competing with E2F-1 for promoter binding. It enhanced the clonogenic growth of granulocyte, erythroid, macrophage, & megakaryocyte cells.It may prevent hematopoietic progenitor cell loss during proliferation. PMID: 17600109
    13. E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells PMID: 17908821

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    E2F/DP family
  • 組織特異性:
    Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
  • 數據庫鏈接:

    HGNC: 3120

    OMIM: 602944

    KEGG: hsa:1876

    STRING: 9606.ENSP00000370936

    UniGene: Hs.603093



主站蜘蛛池模板: 美女内射毛片在线看免费人动物| 成在人线av无码免费看网站直播| 99久久国产综合精品五月天| 久99久热只有精品国产15| 无码aⅴ精品一区二区三区浪潮| 无码人妻精品一区二区三| 美女裸奶100%无遮挡免费网站| 亚洲欧美国产制服图片区| 国产丝袜一区视频在线观看| 中文字幕无码人妻aaa片| 亚洲日韩片无码中文字幕| 亚洲一卡2卡三卡4卡无卡下载| 自拍偷自拍亚洲精品第1页| 欧美疯狂做受xxxx高潮| 国产成人免费ā片在线观看老同学| 色欲人妻aaaaaa无码| 日本高清无卡码一区二区| 99精品视频在线观看免费| 无码一区二区三区中文字幕| 一本av高清一区二区三区| 日本xxxx片免费观看| 在线观看特色大片免费网站| 中文字幕第一区高清av| 18岁日韩内射颜射午夜久久成人| 国产av国片精品jk制服丝袜 | 午夜福利免费0948视频| 99国产精品久久久久久久日本竹| 99在线精品免费视频九九视| 欧美做受视频播放| 精品国模一区二区三区| 美女扒开屁股让男人桶| 国产av一区二区三区无码野战| 无码帝国www无码专区色综合| 欧美 变态 另类 人妖| 亚洲国产成人综合一区二区三区| 中文人妻无码一区二区三区在线| 性高湖久久久久久久久| 国产午夜福利精品一区二区三区| 日本十八禁黄无遮禁视频免费| 亚洲乱码日产精品bd在观看| 99视频偷窥在线精品国自产拍|