在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

E2F6 Antibody

  • 中文名稱:
    E2F6兔多克隆抗體
  • 貨號:
    CSB-PA007347GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    E2F6
  • 別名:
    E2F 6 antibody; E2F binding site modulating activity protein antibody; E2F transcription factor 6 antibody; E2F transcription factor 6 isoform 1 antibody; E2F-6 antibody; E2F6 antibody; E2F6_HUMAN antibody; EMA antibody; MGC111545 antibody; Transcription factor E2F6 antibody
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human E2F6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
  • 基因功能參考文獻:
    1. This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype. PMID: 27909884
    2. After replication stress, the checkpoint kinase Chk1 phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F-dependent transcription, which mediates cell survival by preventing DNA damage and cell death PMID: 23954429
    3. findings indicate an inhibitory role of E2F6 in the regulation of IL-13 and allergy PMID: 22981205
    4. E2F6 may recruit BRG1 in transcriptional regulation of genes important for G1/S phase transition of the cell cycle. PMID: 23082233
    5. data suggest that E2F- and Myc-responsive genes are coregulated by E2F6 complex in quiescent cells PMID: 12004135
    6. results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters PMID: 12909625
    7. contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins PMID: 15081404
    8. E2F6 does not contain the domains required for modulation of squamous differentiation PMID: 15474455
    9. showed that E2F6, DP1, EPC1, EZH2, and Sin3B co-elute, suggesting the identification of a novel E2F6 complex that exists in vivo in both normal and transformed human cell lines PMID: 15536069
    10. functions as a repressor of E2F-dependent transcription during S phase PMID: 15574595
    11. PHC3 and E2F6 showed nuclear colocalization in a punctate pattern which was not seen in proliferating cells suggesting that PHC3 may be part of an E2F6-polycomb complex that has been shown to occupy and silence target promoters in G(0) PMID: 17001316
    12. E2F-6 inhibited Apaf-1 upregulation by competing with E2F-1 for promoter binding. It enhanced the clonogenic growth of granulocyte, erythroid, macrophage, & megakaryocyte cells.It may prevent hematopoietic progenitor cell loss during proliferation. PMID: 17600109
    13. E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells PMID: 17908821

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    E2F/DP family
  • 組織特異性:
    Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
  • 數據庫鏈接:

    HGNC: 3120

    OMIM: 602944

    KEGG: hsa:1876

    STRING: 9606.ENSP00000370936

    UniGene: Hs.603093



主站蜘蛛池模板: 亚洲中文有码字幕日本第一页| 偷拍区清纯另类丝袜美腿| 国产v亚洲v天堂无码久久久 | 国语自产视频在线| 人妻丰满熟妇av无码区app| 十八18禁国产精品www | 51被公侵犯玩弄漂亮人妻| 亚洲欧美综合精品成人网站| 性欧美丰满熟妇xxxx性仙踪林| 久久伊人色av天堂九九| 日韩精品无码一区二区忘忧草| 欧美人与动性xxxxbbbb| 无码视频一区二区三区在线观看| 少妇放荡的呻吟干柴烈火动漫 | 伊人色综合久久天天| 中国人妻被两个老外三p| 蜜臀av999无码精品国产专区 | 国产亚洲精品自在久久vr| 真实的国产乱xxxx| 国产婷婷色一区二区三区在线 | 人妻精品国产一区二区| 亚洲精品一线二线三线区别大吗| 国产乱了伦视频大全亚琴影院| 艳妇乳肉豪妇荡乳av| av成人无码无在线观看| 成年女人片免费视频播放a| 国产精品日本一区二区不卡视频| 亚洲欧美日韩精品色xxx| 日韩av片无码一区二区三区| 高清免费精品国自产拍 | 高清一区二区三区日本久| 成人性三级欧美在线观看| 吃奶呻吟打开双腿做受视频| 真人与拘做受免费视频| 国产一区二区三区在线蜜桃| 亚洲线精品一区二区三八戒| 亚洲丰满熟女一区二区v| 女人色极品影院| 中文人妻av大区中文不卡| 台湾无码一区二区| av人摸人人人澡人人超碰小说|