在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

E2F6 Antibody

  • 中文名稱:
    E2F6兔多克隆抗體
  • 貨號:
    CSB-PA007347GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    E2F6
  • 別名:
    E2F 6 antibody; E2F binding site modulating activity protein antibody; E2F transcription factor 6 antibody; E2F transcription factor 6 isoform 1 antibody; E2F-6 antibody; E2F6 antibody; E2F6_HUMAN antibody; EMA antibody; MGC111545 antibody; Transcription factor E2F6 antibody
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human E2F6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
  • 基因功能參考文獻:
    1. This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype. PMID: 27909884
    2. After replication stress, the checkpoint kinase Chk1 phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F-dependent transcription, which mediates cell survival by preventing DNA damage and cell death PMID: 23954429
    3. findings indicate an inhibitory role of E2F6 in the regulation of IL-13 and allergy PMID: 22981205
    4. E2F6 may recruit BRG1 in transcriptional regulation of genes important for G1/S phase transition of the cell cycle. PMID: 23082233
    5. data suggest that E2F- and Myc-responsive genes are coregulated by E2F6 complex in quiescent cells PMID: 12004135
    6. results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters PMID: 12909625
    7. contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins PMID: 15081404
    8. E2F6 does not contain the domains required for modulation of squamous differentiation PMID: 15474455
    9. showed that E2F6, DP1, EPC1, EZH2, and Sin3B co-elute, suggesting the identification of a novel E2F6 complex that exists in vivo in both normal and transformed human cell lines PMID: 15536069
    10. functions as a repressor of E2F-dependent transcription during S phase PMID: 15574595
    11. PHC3 and E2F6 showed nuclear colocalization in a punctate pattern which was not seen in proliferating cells suggesting that PHC3 may be part of an E2F6-polycomb complex that has been shown to occupy and silence target promoters in G(0) PMID: 17001316
    12. E2F-6 inhibited Apaf-1 upregulation by competing with E2F-1 for promoter binding. It enhanced the clonogenic growth of granulocyte, erythroid, macrophage, & megakaryocyte cells.It may prevent hematopoietic progenitor cell loss during proliferation. PMID: 17600109
    13. E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells PMID: 17908821

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    E2F/DP family
  • 組織特異性:
    Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
  • 數據庫鏈接:

    HGNC: 3120

    OMIM: 602944

    KEGG: hsa:1876

    STRING: 9606.ENSP00000370936

    UniGene: Hs.603093



主站蜘蛛池模板: 国产精品久久国产三级国| 亚洲人成电影网站在线观看| 国产精品av在线| 国产 麻豆 日韩 欧美 久久| 永久免费无码成人网站| 亚洲成αv人片在线观看| 国产微拍精品一区二区| 人妻无码久久久久久久久久久| 国产精品久久久久久久久软件| 免费看女人与公拘交酡过程| 伊人久久大香线蕉综合中文字幕| 真实的国产乱xxxx在线| 亚洲欧美日本国产专区一区| 欧美亚洲国产第一精品久久| 亚洲国产精久久久久久久| 男女猛烈无遮挡免费视频| 97人洗澡人人澡人人爽人人模| 亚洲精品无码伊人久久| 国产精品一区二区av在线观看 | 亚洲免费网站观看视频| 少妇高潮喷水正在播放| 男女作爱免费网站| 免费无码a片一区二三区| 久久久久人妻精品区一三寸| 99久久久无码国产精品9| 精品久久久久久无码人妻| 国产成人精品视频网站| 99精品无人区乱码1区2区3区| 人妻体内射精一区二区三区| 精品无码日韩一区二区三区不卡| 99热国产这里只有精品6| 99久久久无码国产精品9| 深夜福利啪啪片| 国产成人av区一区二区三| 欧美情侣性视频| 精品国精品国产自在久国产87| 亚洲成av人片在线观看天堂无 | 两口子交换真实刺激高潮| 中文字幕v亚洲ⅴv天堂| 色综合久久中文字幕有码| 国产呻吟久久久久久久92|