在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

E2F6 Antibody

  • 中文名稱:
    E2F6兔多克隆抗體
  • 貨號:
    CSB-PA945555
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded human brain tissue using E2F6 antibody.
    • Western blot analysis of extracts from HepG2 cells, using E2F6 antibody.
    • Western blot analysis of extracts from colo cells (Lane 2), using E2F6 antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) E2F6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    E2F6
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human E2F6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
  • 基因功能參考文獻:
    1. This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype. PMID: 27909884
    2. After replication stress, the checkpoint kinase Chk1 phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F-dependent transcription, which mediates cell survival by preventing DNA damage and cell death PMID: 23954429
    3. findings indicate an inhibitory role of E2F6 in the regulation of IL-13 and allergy PMID: 22981205
    4. E2F6 may recruit BRG1 in transcriptional regulation of genes important for G1/S phase transition of the cell cycle. PMID: 23082233
    5. data suggest that E2F- and Myc-responsive genes are coregulated by E2F6 complex in quiescent cells PMID: 12004135
    6. results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters PMID: 12909625
    7. contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins PMID: 15081404
    8. E2F6 does not contain the domains required for modulation of squamous differentiation PMID: 15474455
    9. showed that E2F6, DP1, EPC1, EZH2, and Sin3B co-elute, suggesting the identification of a novel E2F6 complex that exists in vivo in both normal and transformed human cell lines PMID: 15536069
    10. functions as a repressor of E2F-dependent transcription during S phase PMID: 15574595
    11. PHC3 and E2F6 showed nuclear colocalization in a punctate pattern which was not seen in proliferating cells suggesting that PHC3 may be part of an E2F6-polycomb complex that has been shown to occupy and silence target promoters in G(0) PMID: 17001316
    12. E2F-6 inhibited Apaf-1 upregulation by competing with E2F-1 for promoter binding. It enhanced the clonogenic growth of granulocyte, erythroid, macrophage, & megakaryocyte cells.It may prevent hematopoietic progenitor cell loss during proliferation. PMID: 17600109
    13. E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells PMID: 17908821

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    E2F/DP family
  • 組織特異性:
    Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
  • 數據庫鏈接:

    HGNC: 3120

    OMIM: 602944

    KEGG: hsa:1876

    STRING: 9606.ENSP00000370936

    UniGene: Hs.603093



主站蜘蛛池模板: 亚洲视频日本有码中文| 国产精品乱子伦xxxx| 成 人 a v免费视频在线观看 | 99精品国产一区二区三区不卡| 国产老熟女老女人老人| 日韩高清在线亚洲专区小说| 久久不见久久见免费视频1′| 亚洲精品v日韩精品| 成年性生交大片免费看| 朝鲜女人大白屁股ass| 中国女人大白屁股ass| 好紧好爽免费午夜视频| 久久久久久夜精品精品免费啦 | 日本老妇人乱xxy| 久久久久国产精品人妻aⅴ院| 日韩精品国产另类专区| 性色香蕉av久久久天天网| 一二区成人影院电影网| 国产成人欧美综合在线影院| 久青草无码视频在线观看| 狠狠色噜噜狠狠狠狠色综合久av | 中文字字幕在线中文无码| 精品国产一区二区三区久久狼| 天堂va欧美ⅴa亚洲va| 中文字幕精品一二三四五六七八 | 中文无码日韩欧免费视频| 后入内射国产一区二区| 成 人影片 免费观看| 久久综合九色综合97婷婷| 成 人 免 费 黄 色| 色欲av亚洲一区无码少妇| 国产欧美一区二区三区在线看| 亚洲人成无码网www电影麻豆| 亚洲欧美人成网站aaa| 亚洲一区二区三区国产精品无码 | 欧美自拍嘿咻内射在线观看| 国产va免费精品高清在线| 隔壁人妻被水电工征服| 亚洲精品无码久久久| 亚洲中文字幕在线观看| 久99久热只有精品国产女同|