在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

E2F5 Antibody

  • 中文名稱:
    E2F5兔多克隆抗體
  • 貨號:
    CSB-PA007872
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using E2F-5 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    E2F 5 antibody; E2F transcription factor 5 antibody; E2F transcription factor 5 p130 binding antibody; E2F-5 antibody; E2f5 antibody; E2F5_HUMAN antibody; p130 binding antibody; Transcription factor E2F5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human E2F-5.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
  • 基因功能參考文獻:
    1. High E2F5 expression is associated with Glioma. PMID: 29362021
    2. knockdown of E2F5 and PFTK1 mimicked the tumor-suppressive effects of miR-1-3p overexpression on PCa progression. Conversely, concomitant knockdown of miR-1-3p and E2F5 and PFTK1 substantially reversed the inhibitory effects of either E2F5 or PFTK1 silencing alone. PMID: 30185212
    3. miR-1179 overexpression could also inhibit tumor growth in vivo by suppressing the expression of E2F5. PMID: 29859832
    4. FOXN3 functions as a tumor suppressor in hepatocellular carcinoma by downregulating the expression of E2F5. PMID: 27259277
    5. Taken together, these findings indicated that SNHG16 induces breast cancer cell migration by competitively binding miR-98 with E2F5. PMID: 28232182
    6. Our data collectively indicate that miR-613 functions as a tumor suppressor in retinoblastoma through downregulating E2F5, supporting the targeting of the novel miR-613/E2F5 axis as a potentially effective therapeutic approach for retinoblastoma. PMID: 28351331
    7. MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5. PMID: 26103003
    8. miR-98 regulates muscle differentiation by altering the expression of the transcription factor E2F5 and, in turn, of multiple E2F5 targets. PMID: 25422988
    9. In hepatocellular carcinoma cells hepatitis B virus down-regulates E2F5 expression by up-regulating expression of miR-181a. PMID: 24529171
    10. expression of E2F5 in esphageal squamous cell cancer (ESCC) may be correlated with a worse prognosis of patients with ESCC PMID: 24324077
    11. E2F5 may be a novel potential candidate marker for malignant prostate cancer PMID: 23377984
    12. Data indicate that E2F5 is commonly overexpressed in primary hepatocellular carcinomas and show that E2F5 knockdown significantly repressed the growth of HCC cells. PMID: 21274376
    13. cell-cycle regulatory protein E2F5 might play a significant role in epithelial ovarian cancer pathogenesis PMID: 20181230
    14. Diverting the function of E2F5 from a cell-cycle repressor into an activator might contribute to the higher oncogenic potential of HPV18 when compared with other high-risk HPV types. PMID: 20639900
    15. the subcellular distribution of E2F-5 is tightly regulated in intact cells, through multiple functional domains that direct nucleocytoplasmic shuttling of this protein. PMID: 12089160
    16. EBV LPM1 blocks p16INK4 pathway by promoting nuclear export of E2F-5. PMID: 12860972
    17. E2F5 protein is down-regulated late in embryogenesis PMID: 16172982
    18. Overexpression of E2F5/p130 in post-mitotic lens fiber cells does not affect normal differentiation, but can inhibit inappropriate cell cycle reentry induced by activator E2Fs. P130 is key player in inhibitory process. PMID: 18385796
    19. Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. PMID: 19259095

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    E2F/DP family
  • 數據庫鏈接:

    HGNC: 3119

    OMIM: 600967

    KEGG: hsa:1875

    STRING: 9606.ENSP00000398124

    UniGene: Hs.445758



主站蜘蛛池模板: 中文字幕亚洲一区二区三区| 中文字幕无码专区人妻系列| 精品久久久久久亚洲中文字幕| 亚洲精品一区二区三区影院 | 国产精品极品美女自在线观看免费| 国产亚洲精品aaaaaaa片 | 天堂mv在线mv免费mv香蕉| 国产成人美女视频网站| 久久久免费无码成人影片| 日韩欧美亚洲综合久久| 亚洲色无码专区在线观看精品| 国产杨幂丝袜av在线播放| 18禁超污无遮挡无码免费动态图 | 亚洲人成伊人成综合网久久久| 亚洲国产成人久久综合一区| 99热这里只就有精品22| 2020久久天天躁狠狠躁夜夜| 国产精品美女久久久久av爽| 亚洲精品97久久中文字幕无码 | 成年网站未满十八禁视频天堂| 免费观看又色又爽又湿的软件| 男女猛烈xx00免费视频试看| 国产精品刮毛| 久久露脸国产精品| 中文字幕日韩一区二区不卡| 欧美性插b在线视频网站| 黄网站色成年片在线观看| 精品无码久久久久久尤物| 久久综合九色综合久99| 人妻夜夜爽天天爽| 中文字幕无码热在线视频| 一区二区传媒有限公司| 国产乱国产乱老熟300部视频| 成人h动漫无码网站久久| 国产精品久久自在自线不| 97色偷偷色噜噜狠狠爱网站| 免费视频爱爱太爽了激情| 别揉我奶头~嗯~啊~一区二区三区| 66亚洲一卡2卡新区成片发布| 国产亚洲欧美日韩夜色凹凸成人| 国产成+人+综合+亚洲 欧美 |