在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. E2F5 Antibody, Biotin conjugated

E2F5 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    E2F5兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA624021LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) E2F5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    E2F 5 antibody; E2F transcription factor 5 antibody; E2F transcription factor 5 p130 binding antibody; E2F-5 antibody; E2f5 antibody; E2F5_HUMAN antibody; p130 binding antibody; Transcription factor E2F5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription factor E2F5 protein (193-298AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
  • 基因功能參考文獻(xiàn)：
    1. High E2F5 expression is associated with Glioma. PMID: 29362021
    2. knockdown of E2F5 and PFTK1 mimicked the tumor-suppressive effects of miR-1-3p overexpression on PCa progression. Conversely, concomitant knockdown of miR-1-3p and E2F5 and PFTK1 substantially reversed the inhibitory effects of either E2F5 or PFTK1 silencing alone. PMID: 30185212
    3. miR-1179 overexpression could also inhibit tumor growth in vivo by suppressing the expression of E2F5. PMID: 29859832
    4. FOXN3 functions as a tumor suppressor in hepatocellular carcinoma by downregulating the expression of E2F5. PMID: 27259277
    5. Taken together, these findings indicated that SNHG16 induces breast cancer cell migration by competitively binding miR-98 with E2F5. PMID: 28232182
    6. Our data collectively indicate that miR-613 functions as a tumor suppressor in retinoblastoma through downregulating E2F5, supporting the targeting of the novel miR-613/E2F5 axis as a potentially effective therapeutic approach for retinoblastoma. PMID: 28351331
    7. MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5. PMID: 26103003
    8. miR-98 regulates muscle differentiation by altering the expression of the transcription factor E2F5 and, in turn, of multiple E2F5 targets. PMID: 25422988
    9. In hepatocellular carcinoma cells hepatitis B virus down-regulates E2F5 expression by up-regulating expression of miR-181a. PMID: 24529171
    10. expression of E2F5 in esphageal squamous cell cancer (ESCC) may be correlated with a worse prognosis of patients with ESCC PMID: 24324077
    11. E2F5 may be a novel potential candidate marker for malignant prostate cancer PMID: 23377984
    12. Data indicate that E2F5 is commonly overexpressed in primary hepatocellular carcinomas and show that E2F5 knockdown significantly repressed the growth of HCC cells. PMID: 21274376
    13. cell-cycle regulatory protein E2F5 might play a significant role in epithelial ovarian cancer pathogenesis PMID: 20181230
    14. Diverting the function of E2F5 from a cell-cycle repressor into an activator might contribute to the higher oncogenic potential of HPV18 when compared with other high-risk HPV types. PMID: 20639900
    15. the subcellular distribution of E2F-5 is tightly regulated in intact cells, through multiple functional domains that direct nucleocytoplasmic shuttling of this protein. PMID: 12089160
    16. EBV LPM1 blocks p16INK4 pathway by promoting nuclear export of E2F-5. PMID: 12860972
    17. E2F5 protein is down-regulated late in embryogenesis PMID: 16172982
    18. Overexpression of E2F5/p130 in post-mitotic lens fiber cells does not affect normal differentiation, but can inhibit inappropriate cell cycle reentry induced by activator E2Fs. P130 is key player in inhibitory process. PMID: 18385796
    19. Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. PMID: 19259095

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    E2F/DP family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3119

    OMIM: 600967

    KEGG: hsa:1875

    STRING: 9606.ENSP00000398124

    UniGene: Hs.445758



主站蜘蛛池模板： 色综合伊人丁香五月桃花婷婷 | 高清不卡毛片免费观看| 国产在线第一区二区三区| 青青热久免费精品视频| 无码人妻av一区二区三区波多野 | 99e热久久免费精品首页| 国产精品一区二区熟女不卡| 国产又粗又猛又大爽又黄| 在线播放国产精品三级网| 西西人体大胆扒开下部337卩| 狠狠躁天天躁无码中文字幕 | 97久久香蕉国产线看观看| 97久久久人妻一区精品| 国产精品国产对白熟妇| 中文无码人妻有码人妻中文字幕| 理论片午午伦夜理片影院99| 国产福利一区二区三区在线观看| 欧美一区二区三区视频在线观看| 新区乱码无人区二精东| 国产在线精品一品二区| 毛片无码国产| 久久精品中文无码资源站| 成人做爰高潮片免费视频| 内射白嫩少妇超碰| 日韩精品一区二区三区免费视频| 国产96色在线 | 国| 国产成人综合亚洲看片| 精品国产青草久久久久福利| 五十路亲子中出在线观看| 狠狠色噜噜狠狠狠8888在| 欧美疯狂xxxxbbbb喷潮| 久久人人爽人人爽人人片| 两性色午夜视频免费播放| 午夜影视免费x看| 韩国乱码伦视频免费| 免费女人裸体视频无遮挡免费网站 | 国产成人免费一区二区三区| 精品久久久久久久久久久国产字幕| 久久无码超清激情av| 又大又硬又黄的免费视频| 中文在线中文资源|