在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DUSP3 Antibody, FITC conjugated

  • 中文名稱:
    DUSP3兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA007255LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) DUSP3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Dual specificity phosphatase 3 antibody; Dual specificity protein phosphatase 3 antibody; Dual specificity protein phosphatase VHR antibody; DUS3_HUMAN antibody; DUSP3 antibody; Serine/threonine specific protein phosphatase antibody; Vaccinia H1-related phosphatase antibody; Vaccinia virus phosphatase VH1 related antibody; VHR antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dual specificity protein phosphatase 3 protein (14-96AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
  • 基因功能參考文獻:
    1. Nuclear HSP70 leads to enhancement of vaccinia H1-related phosphatase (VHR) activity via protein-protein interaction rather than its molecular chaperone activity, thereby suppressing excessive ERK activation. Downregulation of either VRK3 or HSP70 rendered cells vulnerable to glutamate-induced apoptosis. PMID: 27941812
    2. Data indicated that regulating non-receptor tyrosine kinase FAK and cell migration is a newly revealed function of VHR/DUSP3. PMID: 28759036
    3. The loss of DUSP3 activity markedly increases gamma radiation-induced DNA strand breaks, suggesting a potential novel role for DUSP3 in DNA repair. PMID: 28389334
    4. In PTP1B and VHR, two new allosteric clusters were identified in each enzyme. PMID: 28625849
    5. In the phosphatase-silenced cells, the normal bipolar spindle structure was restored by chemical inhibition of Erk1/2 and ectopic overexpression of Dusp3. We propose that at M phase Dusp3 keeps Erk1/2 activity in check to facilitate normal mitosis. PMID: 27423135
    6. Data suggest levels of gene expression of both DUSP3 (dual specificity phosphatase 3) and PSME3 (proteasome activator subunit 3) are associated with susceptibility to Staphylococcus aureus infection/sepsis in humans and in mouse disease model. PMID: 24901344
    7. Our results demonstrate that DUSP3 plays a key and nonredundant role as a regulator of innate immune responses PMID: 25876765
    8. VHR can dimerize inside cells, and that VHR catalytic activity is reduced upon dimerization. PMID: 24798147
    9. DUSP3 is a pro-angiogenic atypical dual-specificity phosphatase. PMID: 24886454
    10. DUSP3 interacting partners are nucleolar proteins involved in processes related to DNA repair and senescence. PMID: 24245651
    11. we report the first successful site-specific incorporation of sulfotyrisine into VHR through the use of expanding genetic code PMID: 23918168
    12. Proteins containing the class II motifs are efficient VHR substrates in vitro, suggesting that VHR may act on a novel class of yet unidentified Tyr(P) proteins in vivo. PMID: 23322772
    13. Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3 PMID: 21921027
    14. VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis. PMID: 21262974
    15. VHR, a Vaccinia virus VH1-related dual-specific protein phosphatase, is phosphorylated at Y138 by ZAP-70. PMID: 12447358
    16. VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell-cycle phase-dependent manner. PMID: 16604064
    17. deregulated expression of BRCA1-IRIS is likely to reduce dependence on normal physiological growth stimuli PMID: 17278098
    18. Small dual-specificity phosphatase VHR selectively dephosphorylates tyrosine-phosphorylated interferon-alpha- and beta-activated transcription factor STAT5, leading to the subsequent inhibition of STAT5 function. PMID: 17785772
    19. Results highlight the importance of a high intracellular Zn(2+) content and the VHR/ZAP-70/ERK1,2-associated pathways in the modulation of LNCaP prostate cancer cell growth. PMID: 18311544
    20. VHR can be considered as a new marker for cancer progression in cervix carcinoma and potential new target for anticancer therapy PMID: 18505570
    21. VHR has a direct role in the inhibition of JNK-dependent apoptosis in LNCaP cells and may therefore have a role in prostate cancer progression. PMID: 19010898

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3069

    OMIM: 600183

    KEGG: hsa:1845

    STRING: 9606.ENSP00000226004

    UniGene: Hs.181046



主站蜘蛛池模板: 日韩一区二区在线观看视频| 狠狠色色综合网站| 精品乱码一区二区三四五区 | 午夜三级a三级三点窝| 髙清国产性猛交xxxand| 97在线精品视频免费| 成人午夜无码专区性视频性视频 | 久久久久久无码精品人妻a片软件| 国产成人一区二区三区app| 色综合久久一区二区三区| 亚在线观看免费视频入口| 国产精品亚洲精品日韩已满十八小| 夜夜欢性恔真人免费视频| 亚洲综合色区中文字幕| 男人靠女人免费视频网站| 欧美在线 | 亚洲| 欧美综合自拍亚洲综合图片区 | 熟妇人妻激情偷爽文| 天堂…中文在线最新版在线| 亚洲欧美一区二区三区日产| 国产精品无码专区在线观看| 成人精品动漫一区二区| 一本大道东京热无码视频| 先锋影音男人av资源| 人人澡超碰碰97碰碰碰| 狠狠色噜噜狠狠狠狠888奇禾| 久久人妻xunleige无码| 在线观看成人无码中文av天堂不卡| 手机在线看永久av片免费| 国产精品无码免费专区午夜| 亚洲精品无码av人在线观看| 人妻少妇无码中文幕久久| 国产偷窥熟女精品视频| 老太婆性杂交视频| 亚洲成在人线av品善网好看| 亚洲一区二区三区高清在线看| 色综亚洲国产vv在线观看| 国产成人一区二区三区别| 国产精品鲁鲁鲁| aⅴ亚洲 日韩 色 图网站 播放| 麻豆av一区二区天美传媒 |