在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DUSP3 Antibody, Biotin conjugated

  • 中文名稱:
    DUSP3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA007255LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DUSP3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Dual specificity phosphatase 3 antibody; Dual specificity protein phosphatase 3 antibody; Dual specificity protein phosphatase VHR antibody; DUS3_HUMAN antibody; DUSP3 antibody; Serine/threonine specific protein phosphatase antibody; Vaccinia H1-related phosphatase antibody; Vaccinia virus phosphatase VH1 related antibody; VHR antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dual specificity protein phosphatase 3 protein (14-96AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
  • 基因功能參考文獻:
    1. Nuclear HSP70 leads to enhancement of vaccinia H1-related phosphatase (VHR) activity via protein-protein interaction rather than its molecular chaperone activity, thereby suppressing excessive ERK activation. Downregulation of either VRK3 or HSP70 rendered cells vulnerable to glutamate-induced apoptosis. PMID: 27941812
    2. Data indicated that regulating non-receptor tyrosine kinase FAK and cell migration is a newly revealed function of VHR/DUSP3. PMID: 28759036
    3. The loss of DUSP3 activity markedly increases gamma radiation-induced DNA strand breaks, suggesting a potential novel role for DUSP3 in DNA repair. PMID: 28389334
    4. In PTP1B and VHR, two new allosteric clusters were identified in each enzyme. PMID: 28625849
    5. In the phosphatase-silenced cells, the normal bipolar spindle structure was restored by chemical inhibition of Erk1/2 and ectopic overexpression of Dusp3. We propose that at M phase Dusp3 keeps Erk1/2 activity in check to facilitate normal mitosis. PMID: 27423135
    6. Data suggest levels of gene expression of both DUSP3 (dual specificity phosphatase 3) and PSME3 (proteasome activator subunit 3) are associated with susceptibility to Staphylococcus aureus infection/sepsis in humans and in mouse disease model. PMID: 24901344
    7. Our results demonstrate that DUSP3 plays a key and nonredundant role as a regulator of innate immune responses PMID: 25876765
    8. VHR can dimerize inside cells, and that VHR catalytic activity is reduced upon dimerization. PMID: 24798147
    9. DUSP3 is a pro-angiogenic atypical dual-specificity phosphatase. PMID: 24886454
    10. DUSP3 interacting partners are nucleolar proteins involved in processes related to DNA repair and senescence. PMID: 24245651
    11. we report the first successful site-specific incorporation of sulfotyrisine into VHR through the use of expanding genetic code PMID: 23918168
    12. Proteins containing the class II motifs are efficient VHR substrates in vitro, suggesting that VHR may act on a novel class of yet unidentified Tyr(P) proteins in vivo. PMID: 23322772
    13. Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3 PMID: 21921027
    14. VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis. PMID: 21262974
    15. VHR, a Vaccinia virus VH1-related dual-specific protein phosphatase, is phosphorylated at Y138 by ZAP-70. PMID: 12447358
    16. VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell-cycle phase-dependent manner. PMID: 16604064
    17. deregulated expression of BRCA1-IRIS is likely to reduce dependence on normal physiological growth stimuli PMID: 17278098
    18. Small dual-specificity phosphatase VHR selectively dephosphorylates tyrosine-phosphorylated interferon-alpha- and beta-activated transcription factor STAT5, leading to the subsequent inhibition of STAT5 function. PMID: 17785772
    19. Results highlight the importance of a high intracellular Zn(2+) content and the VHR/ZAP-70/ERK1,2-associated pathways in the modulation of LNCaP prostate cancer cell growth. PMID: 18311544
    20. VHR can be considered as a new marker for cancer progression in cervix carcinoma and potential new target for anticancer therapy PMID: 18505570
    21. VHR has a direct role in the inhibition of JNK-dependent apoptosis in LNCaP cells and may therefore have a role in prostate cancer progression. PMID: 19010898

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 數據庫鏈接:

    HGNC: 3069

    OMIM: 600183

    KEGG: hsa:1845

    STRING: 9606.ENSP00000226004

    UniGene: Hs.181046



主站蜘蛛池模板: 激情欧美成人久久综合| 亚洲 综合 校园 欧美 制服 | 精品国产一区二区三区av片| 蜜臀少妇人妻在线| 亚洲一区二区三区四区五区六区| 免费中文字幕日韩欧美| 亚洲中文字幕无码人在线| 人人澡人人澡人人看添av | 国产99久一区二区三区a片| 免费国产成人高清在线视频 | 在线精品自偷自拍无码| 久久人人妻人人做人人爽| 欧美成人综合久久精品| 久久大香线蕉国产精品免费| 国产内射老熟女aaaa| 亚洲日韩精品a∨片无码加勒比| 女人被躁到高潮免费视频 | 亚洲最大成人av在线天堂网| 偷拍区清纯另类丝袜美腿| 性色欲情网站| 国产裸体歌舞一区二区| 国产伦精品免编号公布| 色爱情人网站| 被窝影院午夜无码国产| 国产一区二区三区在线观看免费| 99国产精品自在自在久久| 成人精品动漫一区二区| 久久久97丨国产人妻熟女| 色婷婷综合中文久久一本| 无码午夜福利免费区久久| 污污内射在线观看一区二区少妇| 精品亚洲一区二区三区在线播放 | 中文字幕久久精品波多野结百度| 好男人社区www在线观看| 久久久国产一区二区三区四区小说| 久久久久久妓女精品影院| 日本动漫瀑乳h动漫啪啪免费| 麻麻张开腿让我爽了一夜| 亚洲精品第一国产综合境外资源| 国色天香成人一区二区| 99久久人妻无码精品系列蜜桃|